Sugi Variant

Sugi Variant/CDC45

CDC45 — 367 ClinVar variants

All ClinVar germline CDC45 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 139 flagged for review →

12 Pathogenic · 1 Pathogenic/Likely pathogenic · 10 Likely pathogenic · 12 Conflicting · 37 Benign · 7 Benign/Likely benign · 143 Likely benign · 145 Uncertain significance

Full CDC45 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 139

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors vs ClinVar 4

ClinVar calls these pathogenic, but the computational predictors lean tolerated — the highest-value review flag.

Predictors agree, ClinVar conflicts 4

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 69

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 62

The independent predictors disagree with each other — read with care.

All CDC45 variants

Pathogenic 12

Pathogenic/Likely pathogenic 1

Likely pathogenic 10

Conflicting classifications of pathogenicity 12

Benign 37

Benign/Likely benign 7

Likely benign 143

Uncertain significance 145