CDC7 — 81 ClinVar variants
All ClinVar germline CDC7 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 77 flagged for review →
1 Benign · 3 Likely benign · 77 Uncertain significance
Full CDC7 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 77
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 50
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
-
CDC7 p.Ala254Gly
Uncertain significance
Single submitter
Inborn genetic diseases
- CDC7 p.Ala254Ser Uncertain significance Single submitter
- CDC7 p.Ala38Glu Uncertain significance Single submitter
- CDC7 p.Arg167His Uncertain significance Single submitter
- CDC7 p.Arg367His Uncertain significance Single submitter
- CDC7 p.Asn390Ser Uncertain significance Single submitter
- CDC7 p.Asn519Asp Uncertain significance Single submitter
- CDC7 p.Asp571Gly Uncertain significance Single submitter
- CDC7 p.Cys223Trp Uncertain significance Single submitter
- CDC7 p.Gln249His Uncertain significance Single submitter
- CDC7 p.Gln266His Uncertain significance Single submitter
- CDC7 p.Gln33Arg Uncertain significance Single submitter
- CDC7 p.Gln480Lys Uncertain significance Single submitter
- CDC7 p.Gln8Glu Uncertain significance Single submitter
- CDC7 p.Glu153Asp Uncertain significance Single submitter
- CDC7 p.Glu217Ala Uncertain significance Single submitter
- CDC7 p.Glu301Asp Uncertain significance Single submitter
- CDC7 p.Glu522Lys Uncertain significance Single submitter
- CDC7 p.Gly112Trp Uncertain significance Single submitter
- CDC7 p.Gly273Arg Uncertain significance Single submitter
- CDC7 p.Gly67Ser Uncertain significance Single submitter
- CDC7 p.Gly6Arg Uncertain significance Single submitter
- CDC7 p.His204Arg Uncertain significance Single submitter
- CDC7 p.Ile267Thr Uncertain significance Single submitter
- CDC7 p.Ile44Ser Uncertain significance Single submitter
- CDC7 p.Leu238Val Uncertain significance Single submitter
- CDC7 p.Lys325Asn Uncertain significance Single submitter
- CDC7 p.Lys340Arg Uncertain significance Single submitter
- CDC7 p.Lys387Glu Uncertain significance Single submitter
- CDC7 p.Met13Val Uncertain significance Single submitter
- CDC7 p.Met158Lys Uncertain significance Single submitter
- CDC7 p.Met333Thr Uncertain significance Single submitter
- CDC7 p.Met333Val Uncertain significance Single submitter
- CDC7 p.Met572Lys Uncertain significance Single submitter
- CDC7 p.Phe22Cys Uncertain significance Single submitter
- CDC7 p.Phe58Cys Uncertain significance Single submitter
- CDC7 p.Pro17Ser Uncertain significance Single submitter
- CDC7 p.Pro237Thr Uncertain significance Single submitter
- CDC7 p.Pro259Ser Uncertain significance Single submitter
- CDC7 p.Pro372Ala Uncertain significance Single submitter
- CDC7 p.Pro504Arg Uncertain significance Single submitter
- CDC7 p.Pro83Ser Uncertain significance Single submitter
- CDC7 p.Ser148Phe Uncertain significance Single submitter
- CDC7 p.Ser71Thr Uncertain significance Single submitter
- CDC7 p.Thr261Ala Uncertain significance Single submitter
- CDC7 p.Thr386Pro Uncertain significance Single submitter
- CDC7 p.Tyr260His Uncertain significance Single submitter
- CDC7 p.Val131Gly Uncertain significance Single submitter
- CDC7 p.Val256Ile Uncertain significance Single submitter
- CDC7 p.Val316Ile Uncertain significance Single submitter
Predictors split 27
The independent predictors disagree with each other — read with care.
- CDC7 p.Ala355Val Uncertain significance Single submitter
- CDC7 p.Ala38Thr Uncertain significance Single submitter
- CDC7 p.Ala50Val Uncertain significance Single submitter
- CDC7 p.Arg187Lys Uncertain significance Single submitter
- CDC7 p.Arg188Cys Uncertain significance Single submitter
- CDC7 p.Arg188His Uncertain significance Single submitter
- CDC7 p.Arg411Gln Uncertain significance Single submitter
- CDC7 p.Asp547Gly Uncertain significance Single submitter
- CDC7 p.Cys449Phe Uncertain significance Single submitter
- CDC7 p.Gln201Glu Uncertain significance Single submitter
- CDC7 p.Glu562Ala Uncertain significance Single submitter
- CDC7 p.Ile173Val Uncertain significance Single submitter
- CDC7 p.Ile208Met Likely benign Single submitter
- CDC7 p.Ile447Val Uncertain significance Single submitter
- CDC7 p.Leu37Phe Uncertain significance Single submitter
- CDC7 p.Lys212Thr Uncertain significance Single submitter
- CDC7 p.Lys309Glu Uncertain significance Single submitter
- CDC7 p.Met428Val Uncertain significance Single submitter
- CDC7 p.Ser255Phe Uncertain significance Single submitter
- CDC7 p.Ser296Ile Uncertain significance Single submitter
- CDC7 p.Ser55Asn Uncertain significance Single submitter
- CDC7 p.Ser71Cys Uncertain significance Single submitter
- CDC7 p.Thr330Ile Uncertain significance Single submitter
- CDC7 p.Thr392Ile Uncertain significance Single submitter
- CDC7 p.Thr436Ile Uncertain significance Single submitter
- CDC7 p.Tyr354Cys Uncertain significance Single submitter
- CDC7 p.Tyr48His Uncertain significance Single submitter
All CDC7 variants
Benign 1
- c.-124A>G Multiple submitters
Likely benign 3
- p.Ile208Met Single submitter ⚠
- p.Ile230Val Single submitter
- p.Ile328Val Single submitter
Uncertain significance 77
- p.Ala254Gly Single submitter Inborn genetic diseases ⚠
- p.Ala254Ser Single submitter ⚠
- p.Ala355Val Single submitter ⚠
- p.Ala38Glu Single submitter ⚠
- p.Ala38Thr Single submitter ⚠
- p.Ala50Val Single submitter ⚠
- p.Arg167His Single submitter ⚠
- p.Arg187Lys Single submitter ⚠
- p.Arg188Cys Single submitter ⚠
- p.Arg188His Single submitter ⚠
- p.Arg367His Single submitter ⚠
- p.Arg411Gln Single submitter ⚠
- p.Asn390Ser Single submitter ⚠
- p.Asn519Asp Single submitter ⚠
- p.Asp547Gly Single submitter ⚠
- p.Asp571Gly Single submitter ⚠
- p.Cys223Trp Single submitter ⚠
- p.Cys449Phe Single submitter ⚠
- p.Gln201Glu Single submitter ⚠
- p.Gln249His Single submitter ⚠
- p.Gln266His Single submitter ⚠
- p.Gln33Arg Single submitter ⚠
- p.Gln480Lys Single submitter ⚠
- p.Gln8Glu Single submitter ⚠
- p.Glu153Asp Single submitter ⚠
- p.Glu217Ala Single submitter ⚠
- p.Glu301Asp Single submitter ⚠
- p.Glu522Lys Single submitter ⚠
- p.Glu562Ala Single submitter ⚠
- p.Gly112Trp Single submitter ⚠
- p.Gly273Arg Single submitter ⚠
- p.Gly67Ser Single submitter ⚠
- p.Gly6Arg Single submitter ⚠
- p.His204Arg Single submitter ⚠
- p.Ile173Val Single submitter ⚠
- p.Ile267Thr Single submitter ⚠
- p.Ile447Val Single submitter ⚠
- p.Ile44Ser Single submitter ⚠
- p.Leu238Val Single submitter ⚠
- p.Leu37Phe Single submitter ⚠
- p.Lys212Thr Single submitter ⚠
- p.Lys309Glu Single submitter ⚠
- p.Lys325Asn Single submitter ⚠
- p.Lys340Arg Single submitter ⚠
- p.Lys387Glu Single submitter ⚠
- p.Met13Val Single submitter ⚠
- p.Met158Lys Single submitter ⚠
- p.Met333Thr Single submitter ⚠
- p.Met333Val Single submitter ⚠
- p.Met428Val Single submitter ⚠
- p.Met572Lys Single submitter ⚠
- p.Phe22Cys Single submitter ⚠
- p.Phe58Cys Single submitter ⚠
- p.Pro17Ser Single submitter ⚠
- p.Pro237Thr Single submitter ⚠
- p.Pro259Ser Single submitter ⚠
- p.Pro372Ala Single submitter ⚠
- p.Pro504Arg Single submitter ⚠
- p.Pro83Ser Single submitter ⚠
- p.Ser148Phe Single submitter ⚠
- p.Ser255Phe Single submitter ⚠
- p.Ser296Ile Single submitter ⚠
- p.Ser55Asn Single submitter ⚠
- p.Ser71Cys Single submitter ⚠
- p.Ser71Thr Single submitter ⚠
- p.Thr261Ala Single submitter ⚠
- p.Thr330Ile Single submitter ⚠
- p.Thr386Pro Single submitter ⚠
- p.Thr392Ile Single submitter ⚠
- p.Thr436Ile Single submitter ⚠
- p.Tyr260His Single submitter ⚠
- p.Tyr354Cys Single submitter ⚠
- p.Tyr48His Single submitter ⚠
- p.Val131Gly Single submitter ⚠
- p.Val256Ile Single submitter ⚠
- p.Val316Ile Single submitter ⚠
- p.Lys227_Ser228insTer No assertion criteria premature menopause