CDCA4 — 41 ClinVar variants
All ClinVar germline CDCA4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 40 flagged for review →
2 Likely benign · 39 Uncertain significance
Full CDCA4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 40
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 28
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CDCA4 p.Ala135Val Uncertain significance Single submitter
- CDCA4 p.Ala145Pro Uncertain significance Single submitter
- CDCA4 p.Arg103His Uncertain significance Single submitter
- CDCA4 p.Arg152Gly Uncertain significance Single submitter
- CDCA4 p.Arg80Leu Uncertain significance Single submitter
- CDCA4 p.Arg94His Uncertain significance Single submitter
- CDCA4 p.Asn64Ser Uncertain significance Single submitter
- CDCA4 p.Asp163Glu Uncertain significance Single submitter
- CDCA4 p.Asp227Tyr Uncertain significance Single submitter
- CDCA4 p.Gln123His Uncertain significance Single submitter
- CDCA4 p.Gln35His Uncertain significance Single submitter
- CDCA4 p.Glu211Gly Uncertain significance Single submitter
- CDCA4 p.Gly120Ser Uncertain significance Single submitter
- CDCA4 p.Gly209Glu Uncertain significance Single submitter
- CDCA4 p.Gly229Arg Uncertain significance Single submitter
- CDCA4 p.Gly23Ser Uncertain significance Single submitter
- CDCA4 p.His159Arg Uncertain significance Single submitter
- CDCA4 p.Ile100Phe Uncertain significance Single submitter
- CDCA4 p.Leu37Val Uncertain significance Single submitter
- CDCA4 p.Met148Thr Uncertain significance Single submitter
- CDCA4 p.Met199Ile Uncertain significance Single submitter
- CDCA4 p.Met40Ile Uncertain significance Single submitter
- CDCA4 p.Pro113Ala Uncertain significance Single submitter
- CDCA4 p.Pro204Leu Uncertain significance Single submitter
- CDCA4 p.Ser29Leu Uncertain significance Single submitter
- CDCA4 p.Thr65Met Uncertain significance Single submitter
- CDCA4 p.Thr78Met Uncertain significance Single submitter
- CDCA4 p.Val52Ala Uncertain significance Single submitter
Predictors split 12
The independent predictors disagree with each other — read with care.
- CDCA4 p.Arg34Gln Uncertain significance Single submitter
- CDCA4 p.Arg80Cys Uncertain significance Single submitter
- CDCA4 p.Arg89Trp Uncertain significance Single submitter
- CDCA4 p.Glu208Lys Uncertain significance Single submitter
- CDCA4 p.Glu211Lys Uncertain significance Single submitter
- CDCA4 p.His112Tyr Uncertain significance Single submitter
- CDCA4 p.Leu213Phe Likely benign Single submitter
- CDCA4 p.Met40Leu Uncertain significance Single submitter
- CDCA4 p.Pro218Arg Uncertain significance Single submitter
- CDCA4 p.Ser186Arg Uncertain significance Single submitter
- CDCA4 p.Thr171Ile Uncertain significance Single submitter
- CDCA4 p.Thr74Met Uncertain significance Single submitter
All CDCA4 variants
Likely benign 2
- p.Leu213Phe Single submitter ⚠
- p.Val11Ala Single submitter
Uncertain significance 39
- p.Ala135Val Single submitter ⚠
- p.Ala145Pro Single submitter ⚠
- p.Arg103His Single submitter ⚠
- p.Arg152Gly Single submitter ⚠
- p.Arg34Gln Single submitter ⚠
- p.Arg80Cys Single submitter ⚠
- p.Arg80Leu Single submitter ⚠
- p.Arg89Trp Single submitter ⚠
- p.Arg94His Single submitter ⚠
- p.Asn64Ser Single submitter ⚠
- p.Asp163Glu Single submitter ⚠
- p.Asp227Tyr Single submitter ⚠
- p.Gln123His Single submitter ⚠
- p.Gln35His Single submitter ⚠
- p.Glu208Lys Single submitter ⚠
- p.Glu211Gly Single submitter ⚠
- p.Glu211Lys Single submitter ⚠
- p.Gly120Ser Single submitter ⚠
- p.Gly209Glu Single submitter ⚠
- p.Gly229Arg Single submitter ⚠
- p.Gly23Ser Single submitter ⚠
- p.His112Tyr Single submitter ⚠
- p.His159Arg Single submitter ⚠
- p.Ile100Phe Single submitter ⚠
- p.Leu37Val Single submitter ⚠
- p.Met148Thr Single submitter ⚠
- p.Met199Ile Single submitter ⚠
- p.Met40Ile Single submitter ⚠
- p.Met40Leu Single submitter ⚠
- p.Pro113Ala Single submitter ⚠
- p.Pro204Leu Single submitter ⚠
- p.Pro218Arg Single submitter ⚠
- p.Ser186Arg Single submitter ⚠
- p.Ser29Leu Single submitter ⚠
- p.Thr171Ile Single submitter ⚠
- p.Thr65Met Single submitter ⚠
- p.Thr74Met Single submitter ⚠
- p.Thr78Met Single submitter ⚠
- p.Val52Ala Single submitter ⚠