CDCA5 — 30 ClinVar variants
All ClinVar germline CDCA5 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 23 flagged for review →
5 Benign · 2 Likely benign · 23 Uncertain significance
Full CDCA5 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 23
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 13
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CDCA5 p.Ala51Thr Uncertain significance Single submitter
- CDCA5 p.Asn238Ile Uncertain significance Single submitter
- CDCA5 p.Cys185Ser Uncertain significance Single submitter
- CDCA5 p.Cys195Phe Uncertain significance Single submitter
- CDCA5 p.Glu213Lys Uncertain significance Single submitter
- CDCA5 p.Glu229Asp Uncertain significance Single submitter
- CDCA5 p.Gly170Arg Uncertain significance Single submitter
- CDCA5 p.His106Arg Uncertain significance Single submitter
- CDCA5 p.Pro109Ser Uncertain significance Single submitter
- CDCA5 p.Pro120Arg Uncertain significance Single submitter
- CDCA5 p.Pro223Ser Uncertain significance Single submitter
- CDCA5 p.Ser186Ala Uncertain significance Single submitter
- CDCA5 p.Val59Ile Uncertain significance Single submitter
Predictors split 10
The independent predictors disagree with each other — read with care.
- CDCA5 p.Arg148Trp Uncertain significance Single submitter
- CDCA5 p.Arg4Gly Uncertain significance Single submitter
- CDCA5 p.Arg4Lys Uncertain significance Single submitter
- CDCA5 p.Glu169Lys Uncertain significance Single submitter
- CDCA5 p.Met237Thr Uncertain significance Single submitter
- CDCA5 p.Ser29Phe Uncertain significance Single submitter
- CDCA5 p.Ser8Tyr Uncertain significance Single submitter
- CDCA5 p.Thr228Met Uncertain significance Single submitter
- CDCA5 p.Val183Met Uncertain significance Single submitter
- CDCA5 p.Val73Phe Uncertain significance Single submitter
All CDCA5 variants
Benign 5
- p.Glu123Lys Multiple submitters
- p.Gly173= Multiple submitters
- p.Gly179Arg Multiple submitters
- p.Pro120= Multiple submitters
- p.Thr105= Multiple submitters
Likely benign 2
- c.243+10C>T Single submitter
- p.Lys218= Single submitter
Uncertain significance 23
- p.Ala51Thr Single submitter ⚠
- p.Arg148Trp Single submitter ⚠
- p.Arg4Gly Single submitter ⚠
- p.Arg4Lys Single submitter ⚠
- p.Asn238Ile Single submitter ⚠
- p.Cys185Ser Single submitter ⚠
- p.Cys195Phe Single submitter ⚠
- p.Glu169Lys Single submitter ⚠
- p.Glu213Lys Single submitter ⚠
- p.Glu229Asp Single submitter ⚠
- p.Gly170Arg Single submitter ⚠
- p.His106Arg Single submitter ⚠
- p.Met237Thr Single submitter ⚠
- p.Pro109Ser Single submitter ⚠
- p.Pro120Arg Single submitter ⚠
- p.Pro223Ser Single submitter ⚠
- p.Ser186Ala Single submitter ⚠
- p.Ser29Phe Single submitter ⚠
- p.Ser8Tyr Single submitter ⚠
- p.Thr228Met Single submitter ⚠
- p.Val183Met Single submitter ⚠
- p.Val59Ile Single submitter ⚠
- p.Val73Phe Single submitter ⚠