CDCA7L — 79 ClinVar variants
All ClinVar germline CDCA7L variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 62 flagged for review →
1 Benign · 9 Likely benign · 69 Uncertain significance
Full CDCA7L gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 62
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 56
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CDCA7L p.Ala259Thr Uncertain significance Single submitter
- CDCA7L p.Ala275Val Uncertain significance Single submitter
- CDCA7L p.Ala294Val Uncertain significance Single submitter
- CDCA7L p.Arg143Gln Uncertain significance Single submitter
- CDCA7L p.Arg204Gln Uncertain significance Single submitter
- CDCA7L p.Arg204Trp Uncertain significance Single submitter
- CDCA7L p.Arg301Gln Uncertain significance Single submitter
- CDCA7L p.Arg30Gln Uncertain significance Single submitter
- CDCA7L p.Arg316Cys Uncertain significance Single submitter
- CDCA7L p.Arg318Cys Uncertain significance Single submitter
- CDCA7L p.Arg318His Uncertain significance Single submitter
- CDCA7L p.Arg323Gln Uncertain significance Single submitter
- CDCA7L p.Arg323Leu Uncertain significance Single submitter
- CDCA7L p.Arg341Gln Uncertain significance Single submitter
- CDCA7L p.Arg387Cys Uncertain significance Single submitter
- CDCA7L p.Arg416Trp Uncertain significance Single submitter
- CDCA7L p.Arg59His Uncertain significance Single submitter
- CDCA7L p.Asn454Ser Uncertain significance Single submitter
- CDCA7L p.Asp122His Uncertain significance Single submitter
- CDCA7L p.Asp327Gly Uncertain significance Single submitter
- CDCA7L p.Asp362Asn Uncertain significance Single submitter
- CDCA7L p.Asp437Gly Uncertain significance Single submitter
- CDCA7L p.Asp45Glu Uncertain significance Single submitter
- CDCA7L p.Gln188His Uncertain significance Single submitter
- CDCA7L p.Gln264His Uncertain significance Single submitter
- CDCA7L p.Glu118Lys Uncertain significance Single submitter
- CDCA7L p.Glu121Lys Uncertain significance Single submitter
- CDCA7L p.Glu123Lys Uncertain significance Single submitter
- CDCA7L p.Glu330Lys Uncertain significance Single submitter
- CDCA7L p.Glu75Lys Uncertain significance Single submitter
- CDCA7L p.Ile265Thr Uncertain significance Single submitter
- CDCA7L p.Ile306Thr Uncertain significance Single submitter
- CDCA7L p.Ile306Val Uncertain significance Single submitter
- CDCA7L p.Ile361Val Uncertain significance Single submitter
- CDCA7L p.Ile409Val Uncertain significance Single submitter
- CDCA7L p.Leu153Pro Uncertain significance Single submitter
- CDCA7L p.Leu153Val Uncertain significance Single submitter
- CDCA7L p.Leu180Pro Uncertain significance Single submitter
- CDCA7L p.Lys184Thr Uncertain significance Single submitter
- CDCA7L p.Met219Thr Uncertain significance Single submitter
- CDCA7L p.Phe286Val Uncertain significance Single submitter
- CDCA7L p.Phe293Ser Uncertain significance Single submitter
- CDCA7L p.Pro34Ser Uncertain significance Single submitter
- CDCA7L p.Pro98Ser Uncertain significance Single submitter
- CDCA7L p.Ser108Cys Uncertain significance Single submitter
- CDCA7L p.Ser210Thr Uncertain significance Single submitter
- CDCA7L p.Ser261Leu Uncertain significance Single submitter
- CDCA7L p.Ser394Leu Uncertain significance Single submitter
- CDCA7L p.Ser49Leu Uncertain significance Single submitter
- CDCA7L p.Ser62Cys Uncertain significance Single submitter
- CDCA7L p.Thr88Met Uncertain significance Single submitter
- CDCA7L p.Tyr345Cys Uncertain significance Single submitter
- CDCA7L p.Val103Met Uncertain significance Single submitter
- CDCA7L p.Val144Ile Uncertain significance Single submitter
- CDCA7L p.Val256Ala Uncertain significance Single submitter
- CDCA7L p.Val451Leu Uncertain significance Single submitter
Predictors split 6
The independent predictors disagree with each other — read with care.
- CDCA7L p.Ala294Pro Uncertain significance Single submitter
- CDCA7L p.Arg267Trp Uncertain significance Single submitter
- CDCA7L p.Glu24Lys Uncertain significance Single submitter
- CDCA7L p.Glu80Lys Uncertain significance Single submitter
- CDCA7L p.Pro382Leu Uncertain significance Single submitter
- CDCA7L p.Tyr414Ser Uncertain significance Single submitter
All CDCA7L variants
Benign 1
- c.682-9G>C Single submitter
Likely benign 9
- c.*1333C>T Multiple submitters primary ciliary dyskinesia 7
- c.*1334G>A Multiple submitters primary ciliary dyskinesia 7
- c.*1017_*1048dup Single submitter
- c.*501T>C Single submitter
- p.Ala291Thr Single submitter
- p.Arg171His Single submitter
- p.Arg311Gln Single submitter
- p.Pro157Ser Single submitter
- p.Val102Leu Single submitter
Uncertain significance 69
- c.*1006A>G Single submitter
- c.*1065_*1075del Single submitter primary ciliary dyskinesia 7
- c.*1144C>T Single submitter primary ciliary dyskinesia 7
- c.*1175_*1207del Single submitter
- c.*1287_*1290dup Single submitter primary ciliary dyskinesia 7
- c.*1313C>G Single submitter primary ciliary dyskinesia 7
- p.Ala259Thr Single submitter ⚠
- p.Ala275Val Single submitter ⚠
- p.Ala294Pro Single submitter ⚠
- p.Ala294Val Single submitter ⚠
- p.Arg143Gln Single submitter ⚠
- p.Arg204Gln Single submitter ⚠
- p.Arg204Trp Single submitter ⚠
- p.Arg267Trp Single submitter ⚠
- p.Arg301Gln Single submitter ⚠
- p.Arg30Gln Single submitter ⚠
- p.Arg316Cys Single submitter ⚠
- p.Arg318Cys Single submitter ⚠
- p.Arg318His Single submitter ⚠
- p.Arg323Gln Single submitter ⚠
- p.Arg323Leu Single submitter ⚠
- p.Arg341Gln Single submitter ⚠
- p.Arg385Gln Single submitter
- p.Arg387Cys Single submitter ⚠
- p.Arg416Trp Single submitter ⚠
- p.Arg59His Single submitter ⚠
- p.Asn454Ser Single submitter ⚠
- p.Asp122His Single submitter ⚠
- p.Asp327Gly Single submitter ⚠
- p.Asp362Asn Single submitter ⚠
- p.Asp437Gly Single submitter ⚠
- p.Asp45Glu Single submitter ⚠
- p.Gln188His Single submitter ⚠
- p.Gln264His Single submitter ⚠
- p.Glu118Lys Single submitter ⚠
- p.Glu121Lys Single submitter ⚠
- p.Glu123Lys Single submitter ⚠
- p.Glu24Lys Single submitter ⚠
- p.Glu330Lys Single submitter ⚠
- p.Glu75Lys Single submitter ⚠
- p.Glu80Lys Single submitter ⚠
- p.Ile265Thr Single submitter ⚠
- p.Ile306Thr Single submitter ⚠
- p.Ile306Val Single submitter ⚠
- p.Ile361Val Single submitter ⚠
- p.Ile409Val Single submitter ⚠
- p.Leu153Pro Single submitter ⚠
- p.Leu153Val Single submitter ⚠
- p.Leu180Pro Single submitter ⚠
- p.Lys184Thr Single submitter ⚠
- p.Met219Thr Single submitter ⚠
- p.Phe286Val Single submitter ⚠
- p.Phe293Ser Single submitter ⚠
- p.Pro34Ser Single submitter ⚠
- p.Pro382Leu Single submitter ⚠
- p.Pro98Ser Single submitter ⚠
- p.Ser108Cys Single submitter ⚠
- p.Ser210Thr Single submitter ⚠
- p.Ser261Leu Single submitter ⚠
- p.Ser394Leu Single submitter ⚠
- p.Ser49Leu Single submitter ⚠
- p.Ser62Cys Single submitter ⚠
- p.Thr88Met Single submitter ⚠
- p.Tyr345Cys Single submitter ⚠
- p.Tyr414Ser Single submitter ⚠
- p.Val103Met Single submitter ⚠
- p.Val144Ile Single submitter ⚠
- p.Val256Ala Single submitter ⚠
- p.Val451Leu Single submitter ⚠