CDCA8 — 32 ClinVar variants
All ClinVar germline CDCA8 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 29 flagged for review →
1 Conflicting · 5 Likely benign · 26 Uncertain significance
Full CDCA8 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 29
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 18
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CDCA8 p.Ala140Val Uncertain significance Single submitter
- CDCA8 p.Ala173Val Uncertain significance Single submitter
- CDCA8 p.Arg240Gln Uncertain significance Single submitter
- CDCA8 p.Arg277Gln Uncertain significance Single submitter
- CDCA8 p.Asp120Glu Uncertain significance Single submitter
- CDCA8 p.Gln153His Uncertain significance Single submitter
- CDCA8 p.Glu95Asp Uncertain significance Single submitter
- CDCA8 p.Ile117Met Uncertain significance Single submitter
- CDCA8 p.Ile36Thr Uncertain significance Single submitter
- CDCA8 p.Ile56Val Uncertain significance Single submitter
- CDCA8 p.Lys115Asn Uncertain significance Single submitter
- CDCA8 p.Lys135Thr Uncertain significance Single submitter
- CDCA8 p.Lys162Arg Uncertain significance Single submitter
- CDCA8 p.Lys183Gln Uncertain significance Single submitter
- CDCA8 p.Lys264Gln Uncertain significance Single submitter
- CDCA8 p.Pro146Ser Uncertain significance Single submitter
- CDCA8 p.Pro147Ser Uncertain significance Single submitter
- CDCA8 p.Val179Ala Uncertain significance Single submitter
Predictors split 11
The independent predictors disagree with each other — read with care.
- CDCA8 p.Arg134His Likely benign Single submitter
- CDCA8 p.Arg166Cys Uncertain significance Single submitter
- CDCA8 p.Arg166His Likely benign Single submitter
- CDCA8 p.Arg176Gln Uncertain significance Single submitter
- CDCA8 p.Arg210Trp Uncertain significance Single submitter
- CDCA8 p.Arg35Gln Uncertain significance Single submitter
- CDCA8 p.Glu40Gln Likely benign Single submitter
- CDCA8 p.Gly235Ser Uncertain significance Single submitter
- CDCA8 p.Gly260Arg Uncertain significance Single submitter
- CDCA8 p.Leu21Phe Uncertain significance Single submitter
- CDCA8 p.Phe197Leu Uncertain significance Single submitter
All CDCA8 variants
Conflicting classifications of pathogenicity 1
- c.799-8_799-6del Single submitter CDCA8-related condition
Likely benign 5
- p.Arg134His Single submitter ⚠
- p.Arg166His Single submitter ⚠
- p.Glu40Gln Single submitter ⚠
- p.Ser266= Single submitter
- p.Val50Met Single submitter
Uncertain significance 26
- p.Ala140Val Single submitter ⚠
- p.Ala173Val Single submitter ⚠
- p.Arg166Cys Single submitter ⚠
- p.Arg176Gln Single submitter ⚠
- p.Arg210Trp Single submitter ⚠
- p.Arg240Gln Single submitter ⚠
- p.Arg277Gln Single submitter ⚠
- p.Arg35Gln Single submitter ⚠
- p.Asp120Glu Single submitter ⚠
- p.Gln153His Single submitter ⚠
- p.Glu95Asp Single submitter ⚠
- p.Gly235Ser Single submitter ⚠
- p.Gly260Arg Single submitter ⚠
- p.Ile117Met Single submitter ⚠
- p.Ile36Thr Single submitter ⚠
- p.Ile56Val Single submitter ⚠
- p.Leu21Phe Single submitter ⚠
- p.Lys115Asn Single submitter ⚠
- p.Lys135Thr Single submitter ⚠
- p.Lys162Arg Single submitter ⚠
- p.Lys183Gln Single submitter ⚠
- p.Lys264Gln Single submitter ⚠
- p.Phe197Leu Single submitter ⚠
- p.Pro146Ser Single submitter ⚠
- p.Pro147Ser Single submitter ⚠
- p.Val179Ala Single submitter ⚠