CDCP1 — 118 ClinVar variants
All ClinVar germline CDCP1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 110 flagged for review →
3 Benign · 6 Likely benign · 109 Uncertain significance
Full CDCP1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 110
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 78
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CDCP1 p.Ala212Val Uncertain significance Single submitter
- CDCP1 p.Ala320Thr Uncertain significance Single submitter
- CDCP1 p.Ala464Gly Uncertain significance Single submitter
- CDCP1 p.Ala521Gly Uncertain significance Single submitter
- CDCP1 p.Ala528Ser Uncertain significance Single submitter
- CDCP1 p.Ala604Thr Uncertain significance Single submitter
- CDCP1 p.Ala672Val Uncertain significance Single submitter
- CDCP1 p.Ala783Ser Uncertain significance Single submitter
- CDCP1 p.Arg145His Uncertain significance Single submitter
- CDCP1 p.Arg166Gln Uncertain significance Single submitter
- CDCP1 p.Arg185Gln Uncertain significance Single submitter
- CDCP1 p.Arg214His Uncertain significance Single submitter
- CDCP1 p.Arg261Gln Uncertain significance Single submitter
- CDCP1 p.Arg353Gln Uncertain significance Single submitter
- CDCP1 p.Arg368His Uncertain significance Single submitter
- CDCP1 p.Arg36Gln Uncertain significance Single submitter
- CDCP1 p.Arg381Trp Uncertain significance Single submitter
- CDCP1 p.Arg421Gln Uncertain significance Single submitter
- CDCP1 p.Arg566Gln Uncertain significance Single submitter
- CDCP1 p.Arg603His Uncertain significance Single submitter
- CDCP1 p.Arg612Gln Uncertain significance Single submitter
- CDCP1 p.Arg726Gln Uncertain significance Single submitter
- CDCP1 p.Arg782Gly Uncertain significance Single submitter
- CDCP1 p.Asn270Ser Uncertain significance Single submitter
- CDCP1 p.Asn273Ser Uncertain significance Single submitter
- CDCP1 p.Asn339Ser Uncertain significance Single submitter
- CDCP1 p.Asp492Glu Uncertain significance Single submitter
- CDCP1 p.Cys104Tyr Uncertain significance Single submitter
- CDCP1 p.Cys499Trp Uncertain significance Single submitter
- CDCP1 p.Cys772Tyr Uncertain significance Single submitter
- CDCP1 p.Gln110His Uncertain significance Single submitter
- CDCP1 p.Gln366His Uncertain significance Single submitter
- CDCP1 p.Gln584His Uncertain significance Single submitter
- CDCP1 p.Glu293Gly Uncertain significance Single submitter
- CDCP1 p.Glu360Lys Uncertain significance Single submitter
- CDCP1 p.Glu623Lys Uncertain significance Single submitter
- CDCP1 p.Gly136Ser Uncertain significance Single submitter
- CDCP1 p.Gly150Asp Uncertain significance Single submitter
- CDCP1 p.Gly165Ser Uncertain significance Single submitter
- CDCP1 p.Gly208Ser Uncertain significance Single submitter
- CDCP1 p.Gly685Arg Uncertain significance Single submitter
- CDCP1 p.Gly705Asp Uncertain significance Single submitter
- CDCP1 p.Gly725Glu Uncertain significance Single submitter
- CDCP1 p.Gly752Ser Uncertain significance Single submitter
- CDCP1 p.His395Arg Uncertain significance Single submitter
- CDCP1 p.His472Gln Uncertain significance Single submitter
- CDCP1 p.Ile10Phe Uncertain significance Single submitter
- CDCP1 p.Ile44Val Uncertain significance Single submitter
- CDCP1 p.Ile504Thr Uncertain significance Single submitter
- CDCP1 p.Ile618Leu Uncertain significance Single submitter
- CDCP1 p.Ile671Thr Uncertain significance Single submitter
- CDCP1 p.Ile70Leu Uncertain significance Single submitter
- CDCP1 p.Leu23Arg Uncertain significance Single submitter
- CDCP1 p.Leu670Val Uncertain significance Single submitter
- CDCP1 p.Lys300Thr Uncertain significance Single submitter
- CDCP1 p.Lys720Asn Uncertain significance Single submitter
- CDCP1 p.Lys724Arg Uncertain significance Single submitter
- CDCP1 p.Met741Ile Uncertain significance Single submitter
- CDCP1 p.Met769Val Uncertain significance Single submitter
- CDCP1 p.Pro105His Uncertain significance Single submitter
- CDCP1 p.Pro24Ser Uncertain significance Single submitter
- CDCP1 p.Pro363Thr Uncertain significance Single submitter
- CDCP1 p.Pro463Ser Uncertain significance Single submitter
- CDCP1 p.Pro49Arg Uncertain significance Single submitter
- CDCP1 p.Pro49Leu Uncertain significance Single submitter
- CDCP1 p.Pro831Ala Uncertain significance Single submitter
- CDCP1 p.Ser179Asn Uncertain significance Single submitter
- CDCP1 p.Ser38Gly Uncertain significance Single submitter
- CDCP1 p.Thr50Ile Uncertain significance Single submitter
- CDCP1 p.Thr519Asn Uncertain significance Single submitter
- CDCP1 p.Thr768Ala Uncertain significance Single submitter
- CDCP1 p.Thr821Ile Uncertain significance Single submitter
- CDCP1 p.Tyr345His Uncertain significance Single submitter
- CDCP1 p.Tyr345Phe Uncertain significance Single submitter
- CDCP1 p.Val171Met Uncertain significance Single submitter
- CDCP1 p.Val371Leu Uncertain significance Single submitter
- CDCP1 p.Val597Met Uncertain significance Single submitter
- CDCP1 p.Val8Ala Uncertain significance Single submitter
Predictors split 32
The independent predictors disagree with each other — read with care.
- CDCP1 p.Gly596Ser Benign Multiple submitters
- CDCP1 p.Arg185Trp Uncertain significance Single submitter
- CDCP1 p.Arg261Trp Uncertain significance Single submitter
- CDCP1 p.Arg368Cys Uncertain significance Single submitter
- CDCP1 p.Arg594Gln Uncertain significance Single submitter
- CDCP1 p.Arg594Trp Uncertain significance Single submitter
- CDCP1 p.Arg612Trp Uncertain significance Single submitter
- CDCP1 p.Arg763Trp Uncertain significance Single submitter
- CDCP1 p.Asn563Lys Uncertain significance Single submitter
- CDCP1 p.Asp583Asn Likely benign Single submitter
- CDCP1 p.Asp749Tyr Uncertain significance Single submitter
- CDCP1 p.Glu293Lys Uncertain significance Single submitter
- CDCP1 p.Gly158Arg Uncertain significance Single submitter
- CDCP1 p.Gly231Ala Uncertain significance Single submitter
- CDCP1 p.Gly303Arg Uncertain significance Single submitter
- CDCP1 p.Gly324Trp Uncertain significance Single submitter
- CDCP1 p.Gly676Cys Uncertain significance Single submitter
- CDCP1 p.Ile687Phe Uncertain significance Single submitter
- CDCP1 p.Ile91Thr Uncertain significance Single submitter
- CDCP1 p.Leu626Phe Uncertain significance Single submitter
- CDCP1 p.Phe480Ser Uncertain significance Single submitter
- CDCP1 p.Phe520Leu Uncertain significance Single submitter
- CDCP1 p.Phe541Leu Uncertain significance Single submitter
- CDCP1 p.Ser154Gly Uncertain significance Single submitter
- CDCP1 p.Ser385Gly Uncertain significance Single submitter
- CDCP1 p.Ser61Phe Uncertain significance Single submitter
- CDCP1 p.Ser635Gly Uncertain significance Single submitter
- CDCP1 p.Thr550Asn Uncertain significance Single submitter
- CDCP1 p.Thr66Ala Uncertain significance Single submitter
- CDCP1 p.Val334Ile Uncertain significance Single submitter
- CDCP1 p.Val376Met Uncertain significance Single submitter
- CDCP1 p.Val580Met Uncertain significance Single submitter
All CDCP1 variants
Benign 3
- p.Ala306= Multiple submitters
- p.Arg763Gln Multiple submitters
- p.Gly596Ser Multiple submitters ⚠
Likely benign 6
- p.Asp583Asn Single submitter ⚠
- p.Ile669Val Single submitter
- p.Ser817Asn Single submitter
- p.Val256Ile Single submitter
- p.Val411Ala Single submitter
- p.Val546Ile Single submitter
Uncertain significance 109
- p.Ala212Val Single submitter ⚠
- p.Ala320Thr Single submitter ⚠
- p.Ala464Gly Single submitter ⚠
- p.Ala521Gly Single submitter ⚠
- p.Ala528Ser Single submitter ⚠
- p.Ala604Thr Single submitter ⚠
- p.Ala672Val Single submitter ⚠
- p.Ala783Ser Single submitter ⚠
- p.Arg145His Single submitter ⚠
- p.Arg166Gln Single submitter ⚠
- p.Arg185Gln Single submitter ⚠
- p.Arg185Trp Single submitter ⚠
- p.Arg214His Single submitter ⚠
- p.Arg261Gln Single submitter ⚠
- p.Arg261Trp Single submitter ⚠
- p.Arg353Gln Single submitter ⚠
- p.Arg368Cys Single submitter ⚠
- p.Arg368His Single submitter ⚠
- p.Arg36Gln Single submitter ⚠
- p.Arg381Trp Single submitter ⚠
- p.Arg421Gln Single submitter ⚠
- p.Arg566Gln Single submitter ⚠
- p.Arg594Gln Single submitter ⚠
- p.Arg594Trp Single submitter ⚠
- p.Arg603His Single submitter ⚠
- p.Arg612Gln Single submitter ⚠
- p.Arg612Trp Single submitter ⚠
- p.Arg726Gln Single submitter ⚠
- p.Arg763Trp Single submitter ⚠
- p.Arg782Gly Single submitter ⚠
- p.Asn270Ser Single submitter ⚠
- p.Asn273Ser Single submitter ⚠
- p.Asn339Ser Single submitter ⚠
- p.Asn563Lys Single submitter ⚠
- p.Asp492Glu Single submitter ⚠
- p.Asp749Tyr Single submitter ⚠
- p.Cys104Tyr Single submitter ⚠
- p.Cys499Trp Single submitter ⚠
- p.Cys772Tyr Single submitter ⚠
- p.Gln110His Single submitter ⚠
- p.Gln366His Single submitter ⚠
- p.Gln584His Single submitter ⚠
- p.Glu293Gly Single submitter ⚠
- p.Glu293Lys Single submitter ⚠
- p.Glu360Lys Single submitter ⚠
- p.Glu623Lys Single submitter ⚠
- p.Gly136Ser Single submitter ⚠
- p.Gly150Asp Single submitter ⚠
- p.Gly158Arg Single submitter ⚠
- p.Gly165Ser Single submitter ⚠
- p.Gly208Ser Single submitter ⚠
- p.Gly231Ala Single submitter ⚠
- p.Gly303Arg Single submitter ⚠
- p.Gly324Trp Single submitter ⚠
- p.Gly676Cys Single submitter ⚠
- p.Gly685Arg Single submitter ⚠
- p.Gly705Asp Single submitter ⚠
- p.Gly725Glu Single submitter ⚠
- p.Gly752Ser Single submitter ⚠
- p.His395Arg Single submitter ⚠
- p.His472Gln Single submitter ⚠
- p.Ile10Phe Single submitter ⚠
- p.Ile44Val Single submitter ⚠
- p.Ile504Thr Single submitter ⚠
- p.Ile618Leu Single submitter ⚠
- p.Ile671Thr Single submitter ⚠
- p.Ile687Phe Single submitter ⚠
- p.Ile70Leu Single submitter ⚠
- p.Ile91Thr Single submitter ⚠
- p.Leu23Arg Single submitter ⚠
- p.Leu626Phe Single submitter ⚠
- p.Leu670Val Single submitter ⚠
- p.Lys300Thr Single submitter ⚠
- p.Lys720Asn Single submitter ⚠
- p.Lys724Arg Single submitter ⚠
- p.Met741Ile Single submitter ⚠
- p.Met769Val Single submitter ⚠
- p.Phe480Ser Single submitter ⚠
- p.Phe520Leu Single submitter ⚠
- p.Phe541Leu Single submitter ⚠
- p.Pro105His Single submitter ⚠
- p.Pro24Ser Single submitter ⚠
- p.Pro363Thr Single submitter ⚠
- p.Pro463Ser Single submitter ⚠
- p.Pro49Arg Single submitter ⚠
- p.Pro49Leu Single submitter ⚠
- p.Pro831Ala Single submitter ⚠
- p.Ser154Gly Single submitter ⚠
- p.Ser179Asn Single submitter ⚠
- p.Ser385Gly Single submitter ⚠
- p.Ser38Gly Single submitter ⚠
- p.Ser61Phe Single submitter ⚠
- p.Ser635Gly Single submitter ⚠
- p.Thr50Ile Single submitter ⚠
- p.Thr519Asn Single submitter ⚠
- p.Thr550Asn Single submitter ⚠
- p.Thr66Ala Single submitter ⚠
- p.Thr768Ala Single submitter ⚠
- p.Thr821Ile Single submitter ⚠
- p.Tyr345His Single submitter ⚠
- p.Tyr345Phe Single submitter ⚠
- p.Val171Met Single submitter ⚠
- p.Val334Ile Single submitter ⚠
- p.Val371Leu Single submitter ⚠
- p.Val376Met Single submitter ⚠
- p.Val580Met Single submitter ⚠
- p.Val597Met Single submitter ⚠
- p.Val8Ala Single submitter ⚠
- p.Lys724Ter No assertion criteria myoepithelial tumor