CDCP2 — 88 ClinVar variants
All ClinVar germline CDCP2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 81 flagged for review →
1 Conflicting · 6 Likely benign · 81 Uncertain significance
Full CDCP2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 81
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 43
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CDCP2 c.1117+105C>T Uncertain significance Single submitter
- CDCP2 c.1117+106C>T Uncertain significance Single submitter
- CDCP2 c.1117+10G>A Uncertain significance Single submitter
- CDCP2 c.1117+110G>T Uncertain significance Single submitter
- CDCP2 c.1117+15G>A Uncertain significance Single submitter
- CDCP2 c.1117+168C>G Uncertain significance Single submitter
- CDCP2 c.1117+184C>T Uncertain significance Single submitter
- CDCP2 c.1117+97C>T Uncertain significance Single submitter
- CDCP2 p.Ala14Ser Uncertain significance Single submitter
- CDCP2 p.Ala7Thr Uncertain significance Single submitter
- CDCP2 p.Arg246Cys Uncertain significance Single submitter
- CDCP2 p.Arg265Gln Uncertain significance Single submitter
- CDCP2 p.Arg288His Uncertain significance Single submitter
- CDCP2 p.Arg288Ser Uncertain significance Single submitter
- CDCP2 p.Arg359His Uncertain significance Single submitter
- CDCP2 p.Asn164Tyr Uncertain significance Single submitter
- CDCP2 p.Asp81Glu Uncertain significance Single submitter
- CDCP2 p.Cys336Arg Uncertain significance Single submitter
- CDCP2 p.Cys336Tyr Uncertain significance Single submitter
- CDCP2 p.Cys83Arg Uncertain significance Single submitter
- CDCP2 p.Gly103Arg Uncertain significance Single submitter
- CDCP2 p.Gly135Ala Uncertain significance Single submitter
- CDCP2 p.Gly154Val Uncertain significance Single submitter
- CDCP2 p.Gly219Val Uncertain significance Single submitter
- CDCP2 p.Gly324Glu Uncertain significance Single submitter
- CDCP2 p.Gly365Asp Uncertain significance Single submitter
- CDCP2 p.Gly372Arg Uncertain significance Single submitter
- CDCP2 p.His172Leu Uncertain significance Single submitter
- CDCP2 p.Ile371Val Uncertain significance Single submitter
- CDCP2 p.Leu310Val Uncertain significance Single submitter
- CDCP2 p.Pro180Ser Uncertain significance Single submitter
- CDCP2 p.Pro223Ala Uncertain significance Single submitter
- CDCP2 p.Pro290Ser Uncertain significance Single submitter
- CDCP2 p.Pro291Leu Uncertain significance Single submitter
- CDCP2 p.Pro342Gln Uncertain significance Single submitter
- CDCP2 p.Thr212Pro Uncertain significance Single submitter
- CDCP2 p.Trp173Arg Uncertain significance Single submitter
- CDCP2 p.Trp335Cys Uncertain significance Single submitter
- CDCP2 p.Tyr50His Uncertain significance Single submitter
- CDCP2 p.Val183Asp Uncertain significance Single submitter
- CDCP2 p.Val186Glu Uncertain significance Single submitter
- CDCP2 p.Val297Gly Uncertain significance Single submitter
- CDCP2 p.Val62Glu Uncertain significance Single submitter
Predictors split 38
The independent predictors disagree with each other — read with care.
- CDCP2 p.Ala138Thr Uncertain significance Single submitter
- CDCP2 p.Ala204Val Uncertain significance Single submitter
- CDCP2 p.Ala320Val Uncertain significance Single submitter
- CDCP2 p.Arg176Trp Uncertain significance Single submitter
- CDCP2 p.Arg246Pro Uncertain significance Single submitter
- CDCP2 p.Arg265Trp Uncertain significance Single submitter
- CDCP2 p.Arg288Cys Uncertain significance Single submitter
- CDCP2 p.Asp81Asn Uncertain significance Single submitter
- CDCP2 p.Gln191Leu Uncertain significance Single submitter
- CDCP2 p.Glu232Lys Uncertain significance Single submitter
- CDCP2 p.Glu259Lys Uncertain significance Single submitter
- CDCP2 p.Glu327Lys Uncertain significance Single submitter
- CDCP2 p.Gly139Asp Conflicting Single submitter
- CDCP2 p.Gly154Ala Uncertain significance Single submitter
- CDCP2 p.Gly179Arg Uncertain significance Single submitter
- CDCP2 p.Gly194Val Uncertain significance Single submitter
- CDCP2 p.Gly32Asp Uncertain significance Single submitter
- CDCP2 p.Gly65Glu Uncertain significance Single submitter
- CDCP2 p.Gly6Glu Uncertain significance Single submitter
- CDCP2 p.His339Tyr Uncertain significance Single submitter
- CDCP2 p.Lys296Asn Uncertain significance Single submitter
- CDCP2 p.Met121Ile Uncertain significance Single submitter
- CDCP2 p.Phe41Val Uncertain significance Single submitter
- CDCP2 p.Phe85Cys Uncertain significance Single submitter
- CDCP2 p.Phe87Leu Uncertain significance Single submitter
- CDCP2 p.Pro111Leu Uncertain significance Single submitter
- CDCP2 p.Pro166Leu Uncertain significance Single submitter
- CDCP2 p.Pro18Leu Uncertain significance Single submitter
- CDCP2 p.Pro51Ala Uncertain significance Single submitter
- CDCP2 p.Ser220Gly Uncertain significance Single submitter
- CDCP2 p.Thr115Asn Uncertain significance Single submitter
- CDCP2 p.Thr362Ile Uncertain significance Single submitter
- CDCP2 p.Tyr261Cys Uncertain significance Single submitter
- CDCP2 p.Tyr293His Uncertain significance Single submitter
- CDCP2 p.Val148Ile Uncertain significance Single submitter
- CDCP2 p.Val227Met Uncertain significance Single submitter
- CDCP2 p.Val235Met Uncertain significance Single submitter
- CDCP2 p.Val33Met Uncertain significance Single submitter
All CDCP2 variants
Conflicting classifications of pathogenicity 1
- p.Gly139Asp Single submitter ⚠
Likely benign 6
- c.1117+107_1117+108insCG Single submitter
- c.1117+136A>G Single submitter
- c.1117+175T>C Single submitter
- c.1117+180G>A Single submitter
- p.Arg213His Single submitter
- p.Tyr202= Single submitter
Uncertain significance 81
- c.1117+105C>T Single submitter ⚠
- c.1117+106C>T Single submitter ⚠
- c.1117+10G>A Single submitter ⚠
- c.1117+110G>T Single submitter ⚠
- c.1117+15G>A Single submitter ⚠
- c.1117+168C>G Single submitter ⚠
- c.1117+184C>T Single submitter ⚠
- c.1117+97C>T Single submitter ⚠
- p.Ala138Thr Single submitter ⚠
- p.Ala14Ser Single submitter ⚠
- p.Ala204Val Single submitter ⚠
- p.Ala320Val Single submitter ⚠
- p.Ala7Thr Single submitter ⚠
- p.Arg176Trp Single submitter ⚠
- p.Arg246Cys Single submitter ⚠
- p.Arg246Pro Single submitter ⚠
- p.Arg265Gln Single submitter ⚠
- p.Arg265Trp Single submitter ⚠
- p.Arg288Cys Single submitter ⚠
- p.Arg288His Single submitter ⚠
- p.Arg288Ser Single submitter ⚠
- p.Arg359His Single submitter ⚠
- p.Asn164Tyr Single submitter ⚠
- p.Asp81Asn Single submitter ⚠
- p.Asp81Glu Single submitter ⚠
- p.Cys336Arg Single submitter ⚠
- p.Cys336Tyr Single submitter ⚠
- p.Cys83Arg Single submitter ⚠
- p.Gln191Leu Single submitter ⚠
- p.Glu232Lys Single submitter ⚠
- p.Glu259Lys Single submitter ⚠
- p.Glu327Lys Single submitter ⚠
- p.Gly103Arg Single submitter ⚠
- p.Gly135Ala Single submitter ⚠
- p.Gly154Ala Single submitter ⚠
- p.Gly154Val Single submitter ⚠
- p.Gly179Arg Single submitter ⚠
- p.Gly194Val Single submitter ⚠
- p.Gly219Val Single submitter ⚠
- p.Gly324Glu Single submitter ⚠
- p.Gly32Asp Single submitter ⚠
- p.Gly365Asp Single submitter ⚠
- p.Gly372Arg Single submitter ⚠
- p.Gly65Glu Single submitter ⚠
- p.Gly6Glu Single submitter ⚠
- p.His172Leu Single submitter ⚠
- p.His339Tyr Single submitter ⚠
- p.Ile371Val Single submitter ⚠
- p.Leu310Val Single submitter ⚠
- p.Lys296Asn Single submitter ⚠
- p.Met121Ile Single submitter ⚠
- p.Phe41Val Single submitter ⚠
- p.Phe85Cys Single submitter ⚠
- p.Phe87Leu Single submitter ⚠
- p.Pro111Leu Single submitter ⚠
- p.Pro166Leu Single submitter ⚠
- p.Pro180Ser Single submitter ⚠
- p.Pro18Leu Single submitter ⚠
- p.Pro223Ala Single submitter ⚠
- p.Pro290Ser Single submitter ⚠
- p.Pro291Leu Single submitter ⚠
- p.Pro342Gln Single submitter ⚠
- p.Pro51Ala Single submitter ⚠
- p.Ser220Gly Single submitter ⚠
- p.Thr115Asn Single submitter ⚠
- p.Thr212Pro Single submitter ⚠
- p.Thr362Ile Single submitter ⚠
- p.Trp173Arg Single submitter ⚠
- p.Trp335Cys Single submitter ⚠
- p.Tyr261Cys Single submitter ⚠
- p.Tyr293His Single submitter ⚠
- p.Tyr50His Single submitter ⚠
- p.Val148Ile Single submitter ⚠
- p.Val183Asp Single submitter ⚠
- p.Val186Glu Single submitter ⚠
- p.Val227Met Single submitter ⚠
- p.Val235Met Single submitter ⚠
- p.Val297Gly Single submitter ⚠
- p.Val33Met Single submitter ⚠
- p.Val373Leu Single submitter
- p.Val62Glu Single submitter ⚠