CDH10 — 80 ClinVar variants
All ClinVar germline CDH10 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 73 flagged for review →
3 Benign · 4 Likely benign · 73 Uncertain significance
Full CDH10 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 73
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 40
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
-
CDH10 p.Met316Ile
Uncertain significance
Multiple submitters
CDH10-related condition
-
CDH10 p.Thr159Met
Uncertain significance
Multiple submitters
CDH10-related condition
- CDH10 p.Ala530Val Uncertain significance Single submitter
- CDH10 p.Arg128Cys Uncertain significance Single submitter
- CDH10 p.Arg341Gln Uncertain significance Single submitter
- CDH10 p.Arg40Leu Uncertain significance Single submitter
- CDH10 p.Arg766Gln Uncertain significance Single submitter
- CDH10 p.Asn773Ser Uncertain significance Single submitter
- CDH10 p.Asp481Asn Uncertain significance Single submitter
- CDH10 p.Gln538His Uncertain significance Single submitter
- CDH10 p.Gln668His Uncertain significance Single submitter
- CDH10 p.Glu648Asp Uncertain significance Single submitter
- CDH10 p.His18Arg Uncertain significance Single submitter
- CDH10 p.His354Tyr Uncertain significance Single submitter
- CDH10 p.His4Arg Uncertain significance Single submitter
- CDH10 p.His721Leu Uncertain significance Single submitter
- CDH10 p.Ile164Thr Uncertain significance Single submitter
- CDH10 p.Ile418Val Uncertain significance Single submitter
- CDH10 p.Ile584Val Uncertain significance Single submitter
- CDH10 p.Ile681Asn Uncertain significance Single submitter
- CDH10 p.Ile681Thr Uncertain significance Single submitter
- CDH10 p.Ile690Val Uncertain significance Single submitter
- CDH10 p.Ile744Val Uncertain significance Single submitter
- CDH10 p.Leu101Val Uncertain significance Single submitter
- CDH10 p.Leu451Val Uncertain significance Single submitter
- CDH10 p.Leu748Pro Uncertain significance Single submitter
- CDH10 p.Lys300Arg Uncertain significance Single submitter
- CDH10 p.Met25Val Uncertain significance Single submitter
- CDH10 p.Pro213Ala Uncertain significance Single submitter
- CDH10 p.Pro42Leu Uncertain significance Single submitter
- CDH10 p.Pro729Arg Uncertain significance Single submitter
- CDH10 p.Ser340Asn Uncertain significance Single submitter
- CDH10 p.Ser788Cys Uncertain significance Single submitter
- CDH10 p.Thr166Ser Uncertain significance Single submitter
- CDH10 p.Tyr165Cys Uncertain significance Single submitter
- CDH10 p.Tyr562Cys Uncertain significance Single submitter
- CDH10 p.Val284Ile Uncertain significance Single submitter
- CDH10 p.Val41Ile Uncertain significance Single submitter
- CDH10 p.Asn594Ser Uncertain significance No assertion criteria
- CDH10 p.Val629Ile Uncertain significance No assertion criteria
Predictors split 33
The independent predictors disagree with each other — read with care.
- CDH10 p.Ala296Thr Uncertain significance Single submitter
- CDH10 p.Ala501Val Uncertain significance Single submitter
- CDH10 p.Arg268Cys Uncertain significance Single submitter
- CDH10 p.Arg307Gln Uncertain significance Single submitter
- CDH10 p.Arg358Gly Uncertain significance Single submitter
- CDH10 p.Arg358His Uncertain significance Single submitter
- CDH10 p.Arg771Gln Uncertain significance Single submitter
- CDH10 p.Asp787Gly Uncertain significance Single submitter
- CDH10 p.Gly313Ser Uncertain significance Single submitter
- CDH10 p.Gly46Asp Uncertain significance Single submitter
- CDH10 p.Ile288Thr Uncertain significance Single submitter
- CDH10 p.Ile418Ser Uncertain significance Single submitter
- CDH10 p.Ile460Thr Uncertain significance Single submitter
- CDH10 p.Ile627Thr Uncertain significance Single submitter
- CDH10 p.Leu276Arg Uncertain significance Single submitter
- CDH10 p.Leu605Pro Uncertain significance Single submitter
- CDH10 p.Leu695Phe Uncertain significance Single submitter
- CDH10 p.Lys292Glu Uncertain significance Single submitter
- CDH10 p.Lys323Asn Uncertain significance Single submitter
- CDH10 p.Lys47Glu Uncertain significance Single submitter
- CDH10 p.Phe317Leu Uncertain significance Single submitter
- CDH10 p.Pro213Thr Uncertain significance Single submitter
- CDH10 p.Pro467Ser Uncertain significance Single submitter
- CDH10 p.Pro606Ser Uncertain significance Single submitter
- CDH10 p.Thr100Ala Uncertain significance Single submitter
- CDH10 p.Thr177Ile Uncertain significance Single submitter
- CDH10 p.Thr509Ala Uncertain significance Single submitter
- CDH10 p.Thr544Ala Uncertain significance Single submitter
- CDH10 p.Val182Ile Uncertain significance Single submitter
- CDH10 p.Val278Leu Uncertain significance Single submitter
- CDH10 p.Val459Ile Uncertain significance Single submitter
- CDH10 p.Val473Met Uncertain significance Single submitter
- CDH10 p.Asn465Ser Uncertain significance No assertion criteria
All CDH10 variants
Likely benign 4
- p.Arg472= Single submitter
- p.Ile414Thr Single submitter
- p.Leu506= Single submitter
- p.Leu625= Single submitter
Uncertain significance 73
- p.Met316Ile Multiple submitters CDH10-related condition ⚠
- p.Thr159Met Multiple submitters CDH10-related condition ⚠
- p.Ala296Thr Single submitter ⚠
- p.Ala501Val Single submitter ⚠
- p.Ala530Val Single submitter ⚠
- p.Arg128Cys Single submitter ⚠
- p.Arg268Cys Single submitter ⚠
- p.Arg307Gln Single submitter ⚠
- p.Arg341Gln Single submitter ⚠
- p.Arg358Gly Single submitter ⚠
- p.Arg358His Single submitter ⚠
- p.Arg40Leu Single submitter ⚠
- p.Arg766Gln Single submitter ⚠
- p.Arg771Gln Single submitter ⚠
- p.Asn773Ser Single submitter ⚠
- p.Asp481Asn Single submitter ⚠
- p.Asp787Gly Single submitter ⚠
- p.Gln538His Single submitter ⚠
- p.Gln668His Single submitter ⚠
- p.Glu648Asp Single submitter ⚠
- p.Gly313Ser Single submitter ⚠
- p.Gly46Asp Single submitter ⚠
- p.His18Arg Single submitter ⚠
- p.His354Tyr Single submitter ⚠
- p.His4Arg Single submitter ⚠
- p.His721Leu Single submitter ⚠
- p.Ile164Thr Single submitter ⚠
- p.Ile288Thr Single submitter ⚠
- p.Ile418Ser Single submitter ⚠
- p.Ile418Val Single submitter ⚠
- p.Ile460Thr Single submitter ⚠
- p.Ile584Val Single submitter ⚠
- p.Ile627Thr Single submitter ⚠
- p.Ile681Asn Single submitter ⚠
- p.Ile681Thr Single submitter ⚠
- p.Ile690Val Single submitter ⚠
- p.Ile744Val Single submitter ⚠
- p.Leu101Val Single submitter ⚠
- p.Leu276Arg Single submitter ⚠
- p.Leu451Val Single submitter ⚠
- p.Leu605Pro Single submitter ⚠
- p.Leu695Phe Single submitter ⚠
- p.Leu748Pro Single submitter ⚠
- p.Lys292Glu Single submitter ⚠
- p.Lys300Arg Single submitter ⚠
- p.Lys323Asn Single submitter ⚠
- p.Lys47Glu Single submitter ⚠
- p.Met25Val Single submitter ⚠
- p.Phe317Leu Single submitter ⚠
- p.Pro213Ala Single submitter ⚠
- p.Pro213Thr Single submitter ⚠
- p.Pro42Leu Single submitter ⚠
- p.Pro467Ser Single submitter ⚠
- p.Pro606Ser Single submitter ⚠
- p.Pro729Arg Single submitter ⚠
- p.Ser340Asn Single submitter ⚠
- p.Ser788Cys Single submitter ⚠
- p.Thr100Ala Single submitter ⚠
- p.Thr166Ser Single submitter ⚠
- p.Thr177Ile Single submitter ⚠
- p.Thr509Ala Single submitter ⚠
- p.Thr544Ala Single submitter ⚠
- p.Tyr165Cys Single submitter ⚠
- p.Tyr562Cys Single submitter ⚠
- p.Val182Ile Single submitter ⚠
- p.Val278Leu Single submitter ⚠
- p.Val284Ile Single submitter ⚠
- p.Val41Ile Single submitter ⚠
- p.Val459Ile Single submitter ⚠
- p.Val473Met Single submitter ⚠
- p.Asn465Ser No assertion criteria ⚠
- p.Asn594Ser No assertion criteria ⚠
- p.Val629Ile No assertion criteria ⚠