CDH16 — 158 ClinVar variants

All ClinVar germline CDH16 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 140 flagged for review →

3 Benign · 18 Likely benign · 137 Uncertain significance

Full CDH16 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 140

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors lean, ClinVar uncertain 61

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 79

The independent predictors disagree with each other — read with care.

All CDH16 variants

Benign 3

p.Arg717His Multiple submitters
p.Leu377= Multiple submitters
c.129+8G>A Single submitter

Likely benign 18

p.Ala577Thr Single submitter ⚠
p.Ala648Thr Single submitter
p.Ala650Val Single submitter
p.Arg134Gln Single submitter
p.Arg137Gln Single submitter
p.Arg153Gly Single submitter
p.Arg185Gln Single submitter
p.Arg511Gly Single submitter
p.Asn283= Single submitter
p.Gly103Arg Single submitter ⚠
p.Met420Val Single submitter
p.Pro124= Single submitter
p.Pro277Leu Single submitter ⚠
p.Pro382Ser Single submitter
p.Thr705Ala Single submitter
p.Val13Ile Single submitter
p.Val373Ile Single submitter
p.Val56Met Single submitter

Uncertain significance 137

p.Ala133Ser Single submitter ⚠
p.Ala159Val Single submitter ⚠
p.Ala173Thr Single submitter ⚠
p.Ala202Val Single submitter ⚠
p.Ala20Thr Single submitter ⚠
p.Ala23Thr Single submitter ⚠
p.Ala425Thr Single submitter ⚠
p.Ala438Ser Single submitter ⚠
p.Ala474Thr Single submitter ⚠
p.Ala4Asp Single submitter ⚠
p.Ala549Asp Single submitter ⚠
p.Ala638Val Single submitter ⚠
p.Ala662Asp Single submitter ⚠
p.Ala696Thr Single submitter ⚠
p.Arg134Trp Single submitter ⚠
p.Arg137Trp Single submitter ⚠
p.Arg153Trp Single submitter ⚠
p.Arg185Trp Single submitter ⚠
p.Arg307Gln Single submitter ⚠
p.Arg307Pro Single submitter ⚠
p.Arg389Lys Single submitter ⚠
p.Arg484His Single submitter ⚠
p.Arg48His Single submitter ⚠
p.Arg594Gln Single submitter ⚠
p.Arg679His Single submitter ⚠
p.Arg717Cys Single submitter ⚠
p.Arg738Cys Single submitter ⚠
p.Arg738His Single submitter ⚠
p.Arg772Cys Single submitter ⚠
p.Arg772Ser Single submitter ⚠
p.Arg776His Single submitter ⚠
p.Arg86Gln Single submitter ⚠
p.Asn370Ser Single submitter ⚠
p.Asn443Ser Single submitter ⚠
p.Asn749Ser Single submitter ⚠
p.Asp154Asn Single submitter ⚠
p.Asp200Glu Single submitter ⚠
p.Asp215Glu Single submitter ⚠
p.Asp506Gly Single submitter ⚠
p.Asp815Gly Single submitter ⚠
p.Gln392Pro Single submitter ⚠
p.Gln54Leu Single submitter ⚠
p.Gln719His Single submitter ⚠
p.Glu155Asp Single submitter ⚠
p.Glu314Gly Single submitter ⚠
p.Glu321Gln Single submitter ⚠
p.Glu329Gly Single submitter ⚠
p.Glu329Lys Single submitter ⚠
p.Glu436Asp Single submitter ⚠
p.Glu436Lys Single submitter ⚠
p.Glu464Asp Single submitter ⚠
p.Glu480Lys Single submitter ⚠
p.Glu491Gly Single submitter ⚠
p.Glu504Val Single submitter ⚠
p.Glu616Gln Single submitter ⚠
p.Glu739Lys Single submitter ⚠
p.Glu91Asp Single submitter ⚠
p.Gly367Ser Single submitter ⚠
p.Gly385Arg Single submitter ⚠
p.Gly410Val Single submitter ⚠
p.Gly424Asp Single submitter ⚠
p.Gly500Arg Single submitter ⚠
p.Gly580Ser Single submitter ⚠
p.Gly629Arg Single submitter ⚠
p.Gly67Ser Single submitter ⚠
p.Gly768Arg Single submitter ⚠
p.His323Tyr Single submitter ⚠
p.His618Arg Single submitter ⚠
p.Ile345Val Single submitter ⚠
p.Ile413Asn Single submitter ⚠
p.Ile490Phe Single submitter ⚠
p.Ile592Val Single submitter ⚠
p.Ile610Thr Single submitter ⚠
p.Ile741Thr Single submitter ⚠
p.Ile797Thr Single submitter ⚠
p.Leu189Pro Single submitter ⚠
p.Leu46Pro Single submitter ⚠
p.Leu479Phe Single submitter ⚠
p.Leu518Phe Single submitter ⚠
p.Leu584Val Single submitter ⚠
p.Leu675Phe Single submitter ⚠
p.Leu755Ile Single submitter ⚠
p.Lys19Met Single submitter ⚠
p.Lys658Arg Single submitter ⚠
p.Lys826Glu Single submitter ⚠
p.Met780Val Single submitter ⚠
p.Phe147Leu Single submitter ⚠
p.Phe280Ser Single submitter ⚠
p.Phe77Leu Single submitter ⚠
p.Pro109Leu Single submitter ⚠
p.Pro14Leu Single submitter ⚠
p.Pro18Ser Single submitter ⚠
p.Pro243Ser Single submitter ⚠
p.Pro255Leu Single submitter ⚠
p.Pro279Leu Single submitter ⚠
p.Pro366Leu Single submitter ⚠
p.Pro460Ser Single submitter ⚠
p.Pro524Thr Single submitter ⚠
p.Pro628Ser Single submitter ⚠
p.Pro644Leu Single submitter ⚠
p.Pro660Leu Single submitter ⚠
p.Pro660Ser Single submitter ⚠
p.Pro669Ser Single submitter ⚠
p.Pro68Ser Single submitter ⚠
p.Ser151Pro Single submitter ⚠
p.Ser274Gly Single submitter ⚠
p.Ser368Tyr Single submitter ⚠
p.Ser519Asn Single submitter ⚠
p.Ser576Gly Single submitter ⚠
p.Ser614Pro Single submitter ⚠
p.Ser647Arg Single submitter ⚠
p.Thr342Ile Single submitter ⚠
p.Thr401Met Single submitter ⚠
p.Thr451Ser Single submitter ⚠
p.Thr495Arg Single submitter ⚠
p.Thr550Ser Single submitter ⚠
p.Thr711Met Single submitter ⚠
p.Thr782Met Single submitter ⚠
p.Thr806Ile Single submitter ⚠
p.Thr809Pro Single submitter ⚠
p.Trp716Leu Single submitter ⚠
p.Tyr254His Single submitter ⚠
p.Tyr302Phe Single submitter ⚠
p.Tyr520Cys Single submitter ⚠
p.Tyr632Cys Single submitter ⚠
p.Val123Leu Single submitter ⚠
p.Val211Ile Single submitter ⚠
p.Val29Phe Single submitter ⚠
p.Val324Leu Single submitter ⚠
p.Val324Met Single submitter ⚠
p.Val333Met Single submitter ⚠
p.Val417Ala Single submitter ⚠
p.Val529Met Single submitter ⚠
p.Val551Met Single submitter ⚠
p.Val686Met Single submitter ⚠
p.Val766Met Single submitter ⚠
p.Val823Met Single submitter ⚠