CDH17 — 139 ClinVar variants
All ClinVar germline CDH17 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 128 flagged for review →
5 Benign · 1 Benign/Likely benign · 8 Likely benign · 125 Uncertain significance
Full CDH17 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 128
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 72
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CDH17 p.Ala101Ser Uncertain significance Single submitter
- CDH17 p.Ala157Thr Uncertain significance Single submitter
- CDH17 p.Ala241Ser Uncertain significance Single submitter
- CDH17 p.Ala474Val Uncertain significance Single submitter
- CDH17 p.Ala524Val Uncertain significance Single submitter
- CDH17 p.Ala533Thr Uncertain significance Single submitter
- CDH17 p.Ala822Thr Uncertain significance Single submitter
- CDH17 p.Ala824Glu Uncertain significance Single submitter
- CDH17 p.Arg123Gln Uncertain significance Single submitter
- CDH17 p.Arg140His Uncertain significance Single submitter
- CDH17 p.Arg193Gln Uncertain significance Single submitter
- CDH17 p.Arg607Gly Uncertain significance Single submitter
- CDH17 p.Arg699Gln Uncertain significance Single submitter
- CDH17 p.Arg745His Uncertain significance Single submitter
- CDH17 p.Arg86Thr Uncertain significance Single submitter
- CDH17 p.Asn546Asp Uncertain significance Single submitter
- CDH17 p.Asp291Asn Uncertain significance Single submitter
- CDH17 p.Asp304Glu Uncertain significance Single submitter
- CDH17 p.Asp332Gly Uncertain significance Single submitter
- CDH17 p.Asp368Asn Uncertain significance Single submitter
- CDH17 p.Asp476Asn Uncertain significance Single submitter
- CDH17 p.Asp559Asn Uncertain significance Single submitter
- CDH17 p.Asp662Glu Uncertain significance Single submitter
- CDH17 p.Asp670Asn Uncertain significance Single submitter
- CDH17 p.Asp67Glu Uncertain significance Single submitter
- CDH17 p.Asp715Asn Uncertain significance Single submitter
- CDH17 p.Gln436Lys Uncertain significance Single submitter
- CDH17 p.Gln713Arg Uncertain significance Single submitter
- CDH17 p.Gln713Lys Uncertain significance Single submitter
- CDH17 p.Glu132Lys Uncertain significance Single submitter
- CDH17 p.Glu289Asp Uncertain significance Single submitter
- CDH17 p.Glu353Ala Uncertain significance Single submitter
- CDH17 p.Gly268Ser Uncertain significance Single submitter
- CDH17 p.Gly360Arg Uncertain significance Single submitter
- CDH17 p.Gly511Arg Uncertain significance Single submitter
- CDH17 p.Gly586Ala Uncertain significance Single submitter
- CDH17 p.Gly630Arg Uncertain significance Single submitter
- CDH17 p.Gly644Glu Uncertain significance Single submitter
- CDH17 p.Gly684Val Uncertain significance Single submitter
- CDH17 p.Gly815Ser Uncertain significance Single submitter
- CDH17 p.His327Arg Uncertain significance Single submitter
- CDH17 p.His327Pro Uncertain significance Single submitter
- CDH17 p.His365Gln Uncertain significance Single submitter
- CDH17 p.His614Asp Uncertain significance Single submitter
- CDH17 p.His678Arg Uncertain significance Single submitter
- CDH17 p.His702Asn Uncertain significance Single submitter
- CDH17 p.His92Gln Uncertain significance Single submitter
- CDH17 p.Ile333Val Uncertain significance Single submitter
- CDH17 p.Ile72Val Uncertain significance Single submitter
- CDH17 p.Ile808Thr Uncertain significance Single submitter
- CDH17 p.Leu12Phe Uncertain significance Single submitter
- CDH17 p.Leu362Ile Uncertain significance Single submitter
- CDH17 p.Leu432Ile Uncertain significance Single submitter
- CDH17 p.Lys240Arg Uncertain significance Single submitter
- CDH17 p.Lys532Glu Uncertain significance Single submitter
- CDH17 p.Met34Val Uncertain significance Single submitter
- CDH17 p.Met658Val Uncertain significance Single submitter
- CDH17 p.Phe394Leu Uncertain significance Single submitter
- CDH17 p.Phe698Leu Uncertain significance Single submitter
- CDH17 p.Phe764Cys Uncertain significance Single submitter
- CDH17 p.Ser190Thr Uncertain significance Single submitter
- CDH17 p.Ser548Asn Uncertain significance Single submitter
- CDH17 p.Ser549Tyr Uncertain significance Single submitter
- CDH17 p.Thr510Ile Uncertain significance Single submitter
- CDH17 p.Thr606Ile Uncertain significance Single submitter
- CDH17 p.Thr640Arg Uncertain significance Single submitter
- CDH17 p.Trp716Arg Uncertain significance Single submitter
- CDH17 p.Tyr271His Uncertain significance Single submitter
- CDH17 p.Tyr379Cys Uncertain significance Single submitter
- CDH17 p.Tyr671Asn Uncertain significance Single submitter
- CDH17 p.Val274Asp Uncertain significance Single submitter
- CDH17 p.Val570Ile Uncertain significance Single submitter
Predictors split 56
The independent predictors disagree with each other — read with care.
- CDH17 p.Glu739Ala Benign Multiple submitters
- CDH17 p.Ala241Val Uncertain significance Single submitter
- CDH17 p.Ala573Glu Uncertain significance Single submitter
- CDH17 p.Ala573Val Uncertain significance Single submitter
- CDH17 p.Ala98Val Uncertain significance Single submitter
- CDH17 p.Arg140Cys Uncertain significance Single submitter
- CDH17 p.Arg263Trp Uncertain significance Single submitter
- CDH17 p.Arg699Trp Uncertain significance Single submitter
- CDH17 p.Arg74Trp Uncertain significance Single submitter
- CDH17 p.Arg751Trp Uncertain significance Single submitter
- CDH17 p.Asn438Ser Uncertain significance Single submitter
- CDH17 p.Asn456Ser Benign Single submitter
- CDH17 p.Asp428Ala Uncertain significance Single submitter
- CDH17 p.Asp659Asn Uncertain significance Single submitter
- CDH17 p.Asp693His Uncertain significance Single submitter
- CDH17 p.Gln23Arg Uncertain significance Single submitter
- CDH17 p.Gln636His Uncertain significance Single submitter
- CDH17 p.Gln695Arg Uncertain significance Single submitter
- CDH17 p.Glu194Gly Uncertain significance Single submitter
- CDH17 p.Glu652Lys Uncertain significance Single submitter
- CDH17 p.Glu737Asp Uncertain significance Single submitter
- CDH17 p.Gly29Arg Uncertain significance Single submitter
- CDH17 p.Gly317Arg Uncertain significance Single submitter
- CDH17 p.Gly392Val Uncertain significance Single submitter
- CDH17 p.Ile286Thr Uncertain significance Single submitter
- CDH17 p.Ile422Thr Uncertain significance Single submitter
- CDH17 p.Ile465Asn Uncertain significance Single submitter
- CDH17 p.Ile515Thr Uncertain significance Single submitter
- CDH17 p.Ile556Phe Likely benign Single submitter
- CDH17 p.Leu13Phe Uncertain significance Single submitter
- CDH17 p.Leu362Arg Uncertain significance Single submitter
- CDH17 p.Leu657Ile Uncertain significance Single submitter
- CDH17 p.Leu803Ser Uncertain significance Single submitter
- CDH17 p.Lys313Asn Uncertain significance Single submitter
- CDH17 p.Phe51Val Uncertain significance Single submitter
- CDH17 p.Phe675Ser Uncertain significance Single submitter
- CDH17 p.Pro156Leu Uncertain significance Single submitter
- CDH17 p.Pro30Leu Uncertain significance Single submitter
- CDH17 p.Pro323Leu Uncertain significance Single submitter
- CDH17 p.Pro480Leu Uncertain significance Single submitter
- CDH17 p.Pro518Arg Uncertain significance Single submitter
- CDH17 p.Pro664Leu Uncertain significance Single submitter
- CDH17 p.Ser549Cys Uncertain significance Single submitter
- CDH17 p.Ser649Cys Uncertain significance Single submitter
- CDH17 p.Ser681Cys Uncertain significance Single submitter
- CDH17 p.Ser766Gly Uncertain significance Single submitter
- CDH17 p.Thr421Met Uncertain significance Single submitter
- CDH17 p.Tyr633Ser Uncertain significance Single submitter
- CDH17 p.Val230Leu Uncertain significance Single submitter
- CDH17 p.Val294Met Uncertain significance Single submitter
- CDH17 p.Val382Gly Uncertain significance Single submitter
- CDH17 p.Val382Met Uncertain significance Single submitter
- CDH17 p.Val526Leu Uncertain significance Single submitter
- CDH17 p.Val58Met Uncertain significance Single submitter
- CDH17 p.Val742Ile Likely benign Single submitter
- CDH17 p.Val789Phe Uncertain significance Single submitter
All CDH17 variants
Benign 5
- p.Arg499His Multiple submitters
- p.Glu739Ala Multiple submitters ⚠
- p.Asn456Ser Single submitter ⚠
- p.Leu707= Single submitter
- p.Thr125= Single submitter
Benign/Likely benign 1
- p.Ala788= Multiple submitters
Likely benign 8
- p.Ala18Thr Single submitter
- p.Ala269Val Single submitter
- p.Ile556Phe Single submitter ⚠
- p.Met14Thr Single submitter
- p.Phe735= Single submitter
- p.Thr606Lys Single submitter
- p.Val274Ala Single submitter
- p.Val742Ile Single submitter ⚠
Uncertain significance 125
- c.1796+2T>C Single submitter
- p.Ala101Ser Single submitter ⚠
- p.Ala157Thr Single submitter ⚠
- p.Ala241Ser Single submitter ⚠
- p.Ala241Val Single submitter ⚠
- p.Ala474Val Single submitter ⚠
- p.Ala524Val Single submitter ⚠
- p.Ala533Thr Single submitter ⚠
- p.Ala573Glu Single submitter ⚠
- p.Ala573Val Single submitter ⚠
- p.Ala822Thr Single submitter ⚠
- p.Ala824Glu Single submitter ⚠
- p.Ala98Val Single submitter ⚠
- p.Arg123Gln Single submitter ⚠
- p.Arg140Cys Single submitter ⚠
- p.Arg140His Single submitter ⚠
- p.Arg193Gln Single submitter ⚠
- p.Arg263Trp Single submitter ⚠
- p.Arg607Gly Single submitter ⚠
- p.Arg699Gln Single submitter ⚠
- p.Arg699Trp Single submitter ⚠
- p.Arg745His Single submitter ⚠
- p.Arg74Trp Single submitter ⚠
- p.Arg751Trp Single submitter ⚠
- p.Arg86Thr Single submitter ⚠
- p.Asn438Ser Single submitter ⚠
- p.Asn546Asp Single submitter ⚠
- p.Asp291Asn Single submitter ⚠
- p.Asp304Glu Single submitter ⚠
- p.Asp332Gly Single submitter ⚠
- p.Asp368Asn Single submitter ⚠
- p.Asp428Ala Single submitter ⚠
- p.Asp476Asn Single submitter ⚠
- p.Asp559Asn Single submitter ⚠
- p.Asp659Asn Single submitter ⚠
- p.Asp662Glu Single submitter ⚠
- p.Asp670Asn Single submitter ⚠
- p.Asp67Glu Single submitter ⚠
- p.Asp693His Single submitter ⚠
- p.Asp715Asn Single submitter ⚠
- p.Gln23Arg Single submitter ⚠
- p.Gln436Lys Single submitter ⚠
- p.Gln636His Single submitter ⚠
- p.Gln695Arg Single submitter ⚠
- p.Gln713Arg Single submitter ⚠
- p.Gln713Lys Single submitter ⚠
- p.Glu132Lys Single submitter ⚠
- p.Glu194Gly Single submitter ⚠
- p.Glu289Asp Single submitter ⚠
- p.Glu353Ala Single submitter ⚠
- p.Glu652Lys Single submitter ⚠
- p.Glu737Asp Single submitter ⚠
- p.Gly268Ser Single submitter ⚠
- p.Gly29Arg Single submitter ⚠
- p.Gly317Arg Single submitter ⚠
- p.Gly360Arg Single submitter ⚠
- p.Gly392Val Single submitter ⚠
- p.Gly511Arg Single submitter ⚠
- p.Gly586Ala Single submitter ⚠
- p.Gly630Arg Single submitter ⚠
- p.Gly644Glu Single submitter ⚠
- p.Gly684Val Single submitter ⚠
- p.Gly815Ser Single submitter ⚠
- p.His327Arg Single submitter ⚠
- p.His327Pro Single submitter ⚠
- p.His365Gln Single submitter ⚠
- p.His614Asp Single submitter ⚠
- p.His678Arg Single submitter ⚠
- p.His702Asn Single submitter ⚠
- p.His92Gln Single submitter ⚠
- p.Ile286Thr Single submitter ⚠
- p.Ile333Val Single submitter ⚠
- p.Ile422Thr Single submitter ⚠
- p.Ile465Asn Single submitter ⚠
- p.Ile515Thr Single submitter ⚠
- p.Ile72Val Single submitter ⚠
- p.Ile808Thr Single submitter ⚠
- p.Leu12Phe Single submitter ⚠
- p.Leu13Phe Single submitter ⚠
- p.Leu362Arg Single submitter ⚠
- p.Leu362Ile Single submitter ⚠
- p.Leu432Ile Single submitter ⚠
- p.Leu657Ile Single submitter ⚠
- p.Leu803Ser Single submitter ⚠
- p.Lys240Arg Single submitter ⚠
- p.Lys313Asn Single submitter ⚠
- p.Lys532Glu Single submitter ⚠
- p.Met34Val Single submitter ⚠
- p.Met658Val Single submitter ⚠
- p.Phe394Leu Single submitter ⚠
- p.Phe51Val Single submitter ⚠
- p.Phe675Ser Single submitter ⚠
- p.Phe698Leu Single submitter ⚠
- p.Phe764Cys Single submitter ⚠
- p.Pro156Leu Single submitter ⚠
- p.Pro30Leu Single submitter ⚠
- p.Pro323Leu Single submitter ⚠
- p.Pro480Leu Single submitter ⚠
- p.Pro518Arg Single submitter ⚠
- p.Pro664Leu Single submitter ⚠
- p.Ser190Thr Single submitter ⚠
- p.Ser548Asn Single submitter ⚠
- p.Ser549Cys Single submitter ⚠
- p.Ser549Tyr Single submitter ⚠
- p.Ser649Cys Single submitter ⚠
- p.Ser681Cys Single submitter ⚠
- p.Ser766Gly Single submitter ⚠
- p.Thr421Met Single submitter ⚠
- p.Thr510Ile Single submitter ⚠
- p.Thr606Ile Single submitter ⚠
- p.Thr640Arg Single submitter ⚠
- p.Trp716Arg Single submitter ⚠
- p.Tyr271His Single submitter ⚠
- p.Tyr379Cys Single submitter ⚠
- p.Tyr633Ser Single submitter ⚠
- p.Tyr671Asn Single submitter ⚠
- p.Val230Leu Single submitter ⚠
- p.Val274Asp Single submitter ⚠
- p.Val294Met Single submitter ⚠
- p.Val382Gly Single submitter ⚠
- p.Val382Met Single submitter ⚠
- p.Val526Leu Single submitter ⚠
- p.Val570Ile Single submitter ⚠
- p.Val58Met Single submitter ⚠
- p.Val789Phe Single submitter ⚠