CDH18 — 111 ClinVar variants
All ClinVar germline CDH18 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 102 flagged for review →
2 Benign · 7 Likely benign · 102 Uncertain significance
Full CDH18 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 102
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 55
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CDH18 p.Ala435Thr Uncertain significance Single submitter
- CDH18 p.Ala518Asp Uncertain significance Single submitter
- CDH18 p.Ala602Thr Uncertain significance Single submitter
- CDH18 p.Ala615Gly Uncertain significance Single submitter
- CDH18 p.Ala618Thr Uncertain significance Single submitter
- CDH18 p.Ala682Pro Uncertain significance Single submitter
- CDH18 p.Arg35Thr Uncertain significance Single submitter
- CDH18 p.Arg522Ser Uncertain significance Single submitter
- CDH18 p.Arg558Pro Uncertain significance Single submitter
- CDH18 p.Arg598Gln Uncertain significance Single submitter
- CDH18 p.Asn432His Uncertain significance Single submitter
- CDH18 p.Asn436Ser Uncertain significance Single submitter
- CDH18 p.Asp117Asn Uncertain significance Single submitter
- CDH18 p.Asp117Val Uncertain significance Single submitter
- CDH18 p.Asp225Val Uncertain significance Single submitter
- CDH18 p.Asp428Asn Uncertain significance Single submitter
- CDH18 p.Asp428Glu Uncertain significance Single submitter
- CDH18 p.Asp464Gly Uncertain significance Single submitter
- CDH18 p.Cys600Trp Uncertain significance Single submitter
- CDH18 p.Gln702Arg Uncertain significance Single submitter
- CDH18 p.Glu144Lys Uncertain significance Single submitter
- CDH18 p.Glu46Lys Uncertain significance Single submitter
- CDH18 p.Glu785Asp Uncertain significance Single submitter
- CDH18 p.Gly298Val Uncertain significance Single submitter
- CDH18 p.His48Arg Uncertain significance Single submitter
- CDH18 p.His601Asn Uncertain significance Single submitter
- CDH18 p.His66Asp Uncertain significance Single submitter
- CDH18 p.His701Arg Uncertain significance Single submitter
- CDH18 p.Ile308Leu Uncertain significance Single submitter
- CDH18 p.Ile495Thr Uncertain significance Single submitter
- CDH18 p.Ile750Val Uncertain significance Single submitter
- CDH18 p.Ile784Met Uncertain significance Single submitter
- CDH18 p.Leu624Ile Uncertain significance Single submitter
- CDH18 p.Leu697His Uncertain significance Single submitter
- CDH18 p.Lys291Gln Uncertain significance Single submitter
- CDH18 p.Lys2Glu Uncertain significance Single submitter
- CDH18 p.Met67Ile Uncertain significance Single submitter
- CDH18 p.Met67Val Uncertain significance Single submitter
- CDH18 p.Phe526Leu Uncertain significance Single submitter
- CDH18 p.Phe774Leu Uncertain significance Single submitter
- CDH18 p.Ser557Asn Uncertain significance Single submitter
- CDH18 p.Ser607Phe Uncertain significance Single submitter
- CDH18 p.Thr38Ile Uncertain significance Single submitter
- CDH18 p.Thr413Ser Uncertain significance Single submitter
- CDH18 p.Thr439Ile Uncertain significance Single submitter
- CDH18 p.Thr551Lys Uncertain significance Single submitter
- CDH18 p.Thr613Lys Uncertain significance Single submitter
- CDH18 p.Trp770Arg Uncertain significance Single submitter
- CDH18 p.Tyr191Phe Uncertain significance Single submitter
- CDH18 p.Tyr23Cys Uncertain significance Single submitter
- CDH18 p.Val181Met Uncertain significance Single submitter
- CDH18 p.Val234Ile Uncertain significance Single submitter
- CDH18 p.Val401Ile Uncertain significance Single submitter
- CDH18 p.Val623Ile Uncertain significance Single submitter
- CDH18 p.Val655Met Uncertain significance Single submitter
Predictors split 47
The independent predictors disagree with each other — read with care.
- CDH18 p.Ala609Pro Uncertain significance Single submitter
- CDH18 p.Arg267His Uncertain significance Single submitter
- CDH18 p.Arg357His Uncertain significance Single submitter
- CDH18 p.Arg441Met Uncertain significance Single submitter
- CDH18 p.Arg530His Likely benign Single submitter
- CDH18 p.Arg637Lys Uncertain significance Single submitter
- CDH18 p.Arg688Gln Uncertain significance Single submitter
- CDH18 p.Asn136Lys Uncertain significance Single submitter
- CDH18 p.Asp161Ala Uncertain significance Single submitter
- CDH18 p.Asp211Asn Uncertain significance Single submitter
- CDH18 p.Asp711Gly Uncertain significance Single submitter
- CDH18 p.Glu450Gly Uncertain significance Single submitter
- CDH18 p.Glu487Ala Uncertain significance Single submitter
- CDH18 p.Glu487Lys Uncertain significance Single submitter
- CDH18 p.Glu592Lys Uncertain significance Single submitter
- CDH18 p.Glu694Gln Uncertain significance Single submitter
- CDH18 p.Glu785Gln Uncertain significance Single submitter
- CDH18 p.Gly782Glu Uncertain significance Single submitter
- CDH18 p.His471Tyr Uncertain significance Single submitter
- CDH18 p.Ile131Thr Uncertain significance Single submitter
- CDH18 p.Ile146Val Uncertain significance Single submitter
- CDH18 p.Ile290Met Uncertain significance Single submitter
- CDH18 p.Ile328Asn Uncertain significance Single submitter
- CDH18 p.Ile570Val Uncertain significance Single submitter
- CDH18 p.Ile575Met Uncertain significance Single submitter
- CDH18 p.Ile617Leu Uncertain significance Single submitter
- CDH18 p.Ile619Val Uncertain significance Single submitter
- CDH18 p.Leu361Val Uncertain significance Single submitter
- CDH18 p.Leu468Phe Uncertain significance Single submitter
- CDH18 p.Lys640Glu Uncertain significance Single submitter
- CDH18 p.Lys641Thr Uncertain significance Single submitter
- CDH18 p.Pro643Leu Uncertain significance Single submitter
- CDH18 p.Pro643Thr Uncertain significance Single submitter
- CDH18 p.Pro730Leu Uncertain significance Single submitter
- CDH18 p.Ser209Phe Uncertain significance Single submitter
- CDH18 p.Ser251Tyr Uncertain significance Single submitter
- CDH18 p.Ser342Thr Uncertain significance Single submitter
- CDH18 p.Ser412Arg Uncertain significance Single submitter
- CDH18 p.Thr219Met Uncertain significance Single submitter
- CDH18 p.Thr368Ala Uncertain significance Single submitter
- CDH18 p.Thr404Ile Uncertain significance Single submitter
- CDH18 p.Thr457Ile Uncertain significance Single submitter
- CDH18 p.Thr758Ile Uncertain significance Single submitter
- CDH18 p.Tyr164Cys Uncertain significance Single submitter
- CDH18 p.Tyr419Phe Uncertain significance Single submitter
- CDH18 p.Val234Leu Uncertain significance Single submitter
- CDH18 p.Val56Leu Uncertain significance Single submitter
All CDH18 variants
Likely benign 7
- p.Arg530His Single submitter ⚠
- p.Asn424Ser Single submitter
- p.Cys591= Single submitter
- p.Gly610= Single submitter
- p.Ser608= Single submitter
- p.Ser647= No assertion criteria CDH18-related disorder
- p.Thr473Pro No assertion criteria CDH18-related disorder
Uncertain significance 102
- p.Ala435Thr Single submitter ⚠
- p.Ala518Asp Single submitter ⚠
- p.Ala602Thr Single submitter ⚠
- p.Ala609Pro Single submitter ⚠
- p.Ala615Gly Single submitter ⚠
- p.Ala618Thr Single submitter ⚠
- p.Ala682Pro Single submitter ⚠
- p.Arg267His Single submitter ⚠
- p.Arg357His Single submitter ⚠
- p.Arg35Thr Single submitter ⚠
- p.Arg441Met Single submitter ⚠
- p.Arg522Ser Single submitter ⚠
- p.Arg558Pro Single submitter ⚠
- p.Arg598Gln Single submitter ⚠
- p.Arg637Lys Single submitter ⚠
- p.Arg688Gln Single submitter ⚠
- p.Asn136Lys Single submitter ⚠
- p.Asn432His Single submitter ⚠
- p.Asn436Ser Single submitter ⚠
- p.Asp117Asn Single submitter ⚠
- p.Asp117Val Single submitter ⚠
- p.Asp161Ala Single submitter ⚠
- p.Asp211Asn Single submitter ⚠
- p.Asp225Val Single submitter ⚠
- p.Asp428Asn Single submitter ⚠
- p.Asp428Glu Single submitter ⚠
- p.Asp464Gly Single submitter ⚠
- p.Asp711Gly Single submitter ⚠
- p.Cys600Trp Single submitter ⚠
- p.Gln702Arg Single submitter ⚠
- p.Glu144Lys Single submitter ⚠
- p.Glu450Gly Single submitter ⚠
- p.Glu46Lys Single submitter ⚠
- p.Glu487Ala Single submitter ⚠
- p.Glu487Lys Single submitter ⚠
- p.Glu592Lys Single submitter ⚠
- p.Glu694Gln Single submitter ⚠
- p.Glu785Asp Single submitter ⚠
- p.Glu785Gln Single submitter ⚠
- p.Gly298Val Single submitter ⚠
- p.Gly782Glu Single submitter ⚠
- p.His471Tyr Single submitter ⚠
- p.His48Arg Single submitter ⚠
- p.His601Asn Single submitter ⚠
- p.His66Asp Single submitter ⚠
- p.His701Arg Single submitter ⚠
- p.Ile131Thr Single submitter ⚠
- p.Ile146Val Single submitter ⚠
- p.Ile290Met Single submitter ⚠
- p.Ile308Leu Single submitter ⚠
- p.Ile328Asn Single submitter ⚠
- p.Ile495Thr Single submitter ⚠
- p.Ile570Val Single submitter ⚠
- p.Ile575Met Single submitter ⚠
- p.Ile617Leu Single submitter ⚠
- p.Ile619Val Single submitter ⚠
- p.Ile750Val Single submitter ⚠
- p.Ile784Met Single submitter ⚠
- p.Leu361Val Single submitter ⚠
- p.Leu468Phe Single submitter ⚠
- p.Leu624Ile Single submitter ⚠
- p.Leu697His Single submitter ⚠
- p.Lys291Gln Single submitter ⚠
- p.Lys2Glu Single submitter ⚠
- p.Lys640Glu Single submitter ⚠
- p.Lys641Thr Single submitter ⚠
- p.Met67Ile Single submitter ⚠
- p.Met67Val Single submitter ⚠
- p.Phe526Leu Single submitter ⚠
- p.Phe774Leu Single submitter ⚠
- p.Pro643Leu Single submitter ⚠
- p.Pro643Thr Single submitter ⚠
- p.Pro730Leu Single submitter ⚠
- p.Ser209Phe Single submitter ⚠
- p.Ser251Tyr Single submitter ⚠
- p.Ser342Thr Single submitter ⚠
- p.Ser412Arg Single submitter ⚠
- p.Ser557Asn Single submitter ⚠
- p.Ser607Phe Single submitter ⚠
- p.Thr219Met Single submitter ⚠
- p.Thr368Ala Single submitter ⚠
- p.Thr38Ile Single submitter ⚠
- p.Thr404Ile Single submitter ⚠
- p.Thr413Ser Single submitter ⚠
- p.Thr439Ile Single submitter ⚠
- p.Thr457Ile Single submitter ⚠
- p.Thr551Lys Single submitter ⚠
- p.Thr613Lys Single submitter ⚠
- p.Thr758Ile Single submitter ⚠
- p.Trp770Arg Single submitter ⚠
- p.Tyr164Cys Single submitter ⚠
- p.Tyr191Phe Single submitter ⚠
- p.Tyr23Cys Single submitter ⚠
- p.Tyr419Phe Single submitter ⚠
- p.Val181Met Single submitter ⚠
- p.Val234Ile Single submitter ⚠
- p.Val234Leu Single submitter ⚠
- p.Val401Ile Single submitter ⚠
- p.Val56Leu Single submitter ⚠
- p.Val623Ile Single submitter ⚠
- p.Val655Met Single submitter ⚠
- p.Leu331= No assertion criteria childhood apraxia of speech