CDH20 — 112 ClinVar variants
All ClinVar germline CDH20 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 108 flagged for review →
1 Benign · 3 Likely benign · 108 Uncertain significance
Full CDH20 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 108
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 53
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CDH20 p.Ala226Val Uncertain significance Single submitter
- CDH20 p.Ala627Thr Uncertain significance Single submitter
- CDH20 p.Ala691Thr Uncertain significance Single submitter
- CDH20 p.Ala717Thr Uncertain significance Single submitter
- CDH20 p.Arg124Gln Uncertain significance Single submitter
- CDH20 p.Arg546Lys Uncertain significance Single submitter
- CDH20 p.Arg554Gln Uncertain significance Single submitter
- CDH20 p.Arg563Gln Uncertain significance Single submitter
- CDH20 p.Asn525Asp Uncertain significance Single submitter
- CDH20 p.Asp384Glu Uncertain significance Single submitter
- CDH20 p.Asp440Asn Uncertain significance Single submitter
- CDH20 p.Asp679Asn Uncertain significance Single submitter
- CDH20 p.Asp779Glu Uncertain significance Single submitter
- CDH20 p.Cys716Ser Uncertain significance Single submitter
- CDH20 p.Gln52Arg Uncertain significance Single submitter
- CDH20 p.Gln648Pro Uncertain significance Single submitter
- CDH20 p.Gln764His Uncertain significance Single submitter
- CDH20 p.Gln764Pro Uncertain significance Single submitter
- CDH20 p.Glu236Asp Uncertain significance Single submitter
- CDH20 p.Glu660Gly Uncertain significance Single submitter
- CDH20 p.Gly17Ser Uncertain significance Single submitter
- CDH20 p.Gly24Trp Uncertain significance Single submitter
- CDH20 p.Gly294Arg Uncertain significance Single submitter
- CDH20 p.Gly796Arg Uncertain significance Single submitter
- CDH20 p.Ile305Val Uncertain significance Single submitter
- CDH20 p.Ile411Thr Uncertain significance Single submitter
- CDH20 p.Ile545Thr Uncertain significance Single submitter
- CDH20 p.Ile625Thr Uncertain significance Single submitter
- CDH20 p.Ile651Val Uncertain significance Single submitter
- CDH20 p.Leu122Phe Uncertain significance Single submitter
- CDH20 p.Leu708Ile Uncertain significance Single submitter
- CDH20 p.Leu98Phe Uncertain significance Single submitter
- CDH20 p.Lys245Glu Uncertain significance Single submitter
- CDH20 p.Lys729Arg Uncertain significance Single submitter
- CDH20 p.Met145Val Uncertain significance Single submitter
- CDH20 p.Met281Thr Uncertain significance Single submitter
- CDH20 p.Met309Thr Uncertain significance Single submitter
- CDH20 p.Met642Val Uncertain significance Single submitter
- CDH20 p.Met701Ile Uncertain significance Single submitter
- CDH20 p.Met735Thr Uncertain significance Single submitter
- CDH20 p.Phe297Ile Uncertain significance Single submitter
- CDH20 p.Phe742Leu Uncertain significance Single submitter
- CDH20 p.Pro740Ser Uncertain significance Single submitter
- CDH20 p.Pro797Ser Uncertain significance Single submitter
- CDH20 p.Ser720Thr Uncertain significance Single submitter
- CDH20 p.Ser8Asn Uncertain significance Single submitter
- CDH20 p.Thr29Met Uncertain significance Single submitter
- CDH20 p.Thr715Pro Uncertain significance Single submitter
- CDH20 p.Thr73Ala Uncertain significance Single submitter
- CDH20 p.Tyr130His Uncertain significance Single submitter
- CDH20 p.Val332Ile Uncertain significance Single submitter
- CDH20 p.Val603Ile Uncertain significance Single submitter
- CDH20 p.Val756Ala Uncertain significance Single submitter
Predictors split 55
The independent predictors disagree with each other — read with care.
-
CDH20 p.Arg687Trp
Uncertain significance
Multiple submitters
non-syndromic syndactyly
- CDH20 p.Ala403Val Uncertain significance Single submitter
- CDH20 p.Ala506Thr Uncertain significance Single submitter
- CDH20 p.Ala610Val Uncertain significance Single submitter
- CDH20 p.Arg224Lys Uncertain significance Single submitter
- CDH20 p.Arg273His Uncertain significance Single submitter
- CDH20 p.Arg295Thr Uncertain significance Single submitter
- CDH20 p.Arg363Cys Uncertain significance Single submitter
- CDH20 p.Arg363His Uncertain significance Single submitter
- CDH20 p.Arg429Ser Uncertain significance Single submitter
- CDH20 p.Arg559Lys Uncertain significance Single submitter
- CDH20 p.Arg563Trp Uncertain significance Single submitter
- CDH20 p.Arg698Leu Uncertain significance Single submitter
- CDH20 p.Asn540Ser Uncertain significance Single submitter
- CDH20 p.Asn542Ser Uncertain significance Single submitter
- CDH20 p.Asn551Tyr Uncertain significance Single submitter
- CDH20 p.Asp700Asn Uncertain significance Single submitter
- CDH20 p.Asp76Glu Uncertain significance Single submitter
- CDH20 p.Asp779His Uncertain significance Single submitter
- CDH20 p.Gln567Lys Uncertain significance Single submitter
- CDH20 p.Gln772Arg Uncertain significance Single submitter
- CDH20 p.Gln772Leu Uncertain significance Single submitter
- CDH20 p.Glu148Lys Uncertain significance Single submitter
- CDH20 p.Glu397Asp Uncertain significance Single submitter
- CDH20 p.Glu704Val Uncertain significance Single submitter
- CDH20 p.Gly104Ser Uncertain significance Single submitter
- CDH20 p.Gly142Ser Uncertain significance Single submitter
- CDH20 p.Gly405Ala Uncertain significance Single submitter
- CDH20 p.Gly580Arg Uncertain significance Single submitter
- CDH20 p.Gly601Ser Uncertain significance Single submitter
- CDH20 p.Ile152Leu Uncertain significance Single submitter
- CDH20 p.Ile289Thr Uncertain significance Single submitter
- CDH20 p.Ile623Leu Uncertain significance Single submitter
- CDH20 p.Ile623Thr Uncertain significance Single submitter
- CDH20 p.Ile658Thr Uncertain significance Single submitter
- CDH20 p.Leu122Ile Uncertain significance Single submitter
- CDH20 p.Lys352Asn Uncertain significance Single submitter
- CDH20 p.Pro451Leu Uncertain significance Single submitter
- CDH20 p.Ser282Arg Uncertain significance Single submitter
- CDH20 p.Ser34Leu Uncertain significance Single submitter
- CDH20 p.Ser616Asn Uncertain significance Single submitter
- CDH20 p.Ser762Ala Uncertain significance Single submitter
- CDH20 p.Ser765Pro Uncertain significance Single submitter
- CDH20 p.Thr112Ala Uncertain significance Single submitter
- CDH20 p.Thr141Met Uncertain significance Single submitter
- CDH20 p.Thr375Ile Uncertain significance Single submitter
- CDH20 p.Thr544Asn Uncertain significance Single submitter
- CDH20 p.Thr589Ile Uncertain significance Single submitter
- CDH20 p.Thr778Pro Uncertain significance Single submitter
- CDH20 p.Tyr611His Uncertain significance Single submitter
- CDH20 p.Val203Met Uncertain significance Single submitter
- CDH20 p.Val222Ala Uncertain significance Single submitter
- CDH20 p.Val293Ile Uncertain significance Single submitter
- CDH20 p.Val615Phe Uncertain significance Single submitter
- CDH20 p.Val636Ala Uncertain significance Single submitter
All CDH20 variants
Benign 1
- p.Pro39= Multiple submitters
Uncertain significance 108
- p.Arg687Trp Multiple submitters non-syndromic syndactyly ⚠
- p.Ala226Val Single submitter ⚠
- p.Ala403Val Single submitter ⚠
- p.Ala506Thr Single submitter ⚠
- p.Ala610Val Single submitter ⚠
- p.Ala627Thr Single submitter ⚠
- p.Ala691Thr Single submitter ⚠
- p.Ala717Thr Single submitter ⚠
- p.Arg124Gln Single submitter ⚠
- p.Arg224Lys Single submitter ⚠
- p.Arg273His Single submitter ⚠
- p.Arg295Thr Single submitter ⚠
- p.Arg363Cys Single submitter ⚠
- p.Arg363His Single submitter ⚠
- p.Arg429Ser Single submitter ⚠
- p.Arg546Lys Single submitter ⚠
- p.Arg554Gln Single submitter ⚠
- p.Arg559Lys Single submitter ⚠
- p.Arg563Gln Single submitter ⚠
- p.Arg563Trp Single submitter ⚠
- p.Arg698Leu Single submitter ⚠
- p.Asn525Asp Single submitter ⚠
- p.Asn540Ser Single submitter ⚠
- p.Asn542Ser Single submitter ⚠
- p.Asn551Tyr Single submitter ⚠
- p.Asp384Glu Single submitter ⚠
- p.Asp440Asn Single submitter ⚠
- p.Asp679Asn Single submitter ⚠
- p.Asp700Asn Single submitter ⚠
- p.Asp76Glu Single submitter ⚠
- p.Asp779Glu Single submitter ⚠
- p.Asp779His Single submitter ⚠
- p.Cys716Ser Single submitter ⚠
- p.Gln52Arg Single submitter ⚠
- p.Gln567Lys Single submitter ⚠
- p.Gln648Pro Single submitter ⚠
- p.Gln764His Single submitter ⚠
- p.Gln764Pro Single submitter ⚠
- p.Gln772Arg Single submitter ⚠
- p.Gln772Leu Single submitter ⚠
- p.Glu148Lys Single submitter ⚠
- p.Glu236Asp Single submitter ⚠
- p.Glu397Asp Single submitter ⚠
- p.Glu660Gly Single submitter ⚠
- p.Glu704Val Single submitter ⚠
- p.Gly104Ser Single submitter ⚠
- p.Gly142Ser Single submitter ⚠
- p.Gly17Ser Single submitter ⚠
- p.Gly24Trp Single submitter ⚠
- p.Gly294Arg Single submitter ⚠
- p.Gly405Ala Single submitter ⚠
- p.Gly580Arg Single submitter ⚠
- p.Gly601Ser Single submitter ⚠
- p.Gly796Arg Single submitter ⚠
- p.Ile152Leu Single submitter ⚠
- p.Ile289Thr Single submitter ⚠
- p.Ile305Val Single submitter ⚠
- p.Ile411Thr Single submitter ⚠
- p.Ile545Thr Single submitter ⚠
- p.Ile623Leu Single submitter ⚠
- p.Ile623Thr Single submitter ⚠
- p.Ile625Thr Single submitter ⚠
- p.Ile651Val Single submitter ⚠
- p.Ile658Thr Single submitter ⚠
- p.Leu122Ile Single submitter ⚠
- p.Leu122Phe Single submitter ⚠
- p.Leu708Ile Single submitter ⚠
- p.Leu98Phe Single submitter ⚠
- p.Lys245Glu Single submitter ⚠
- p.Lys352Asn Single submitter ⚠
- p.Lys729Arg Single submitter ⚠
- p.Met145Val Single submitter ⚠
- p.Met281Thr Single submitter ⚠
- p.Met309Thr Single submitter ⚠
- p.Met642Val Single submitter ⚠
- p.Met701Ile Single submitter ⚠
- p.Met735Thr Single submitter ⚠
- p.Phe297Ile Single submitter ⚠
- p.Phe742Leu Single submitter ⚠
- p.Pro451Leu Single submitter ⚠
- p.Pro740Ser Single submitter ⚠
- p.Pro797Ser Single submitter ⚠
- p.Ser282Arg Single submitter ⚠
- p.Ser34Leu Single submitter ⚠
- p.Ser616Asn Single submitter ⚠
- p.Ser720Thr Single submitter ⚠
- p.Ser762Ala Single submitter ⚠
- p.Ser765Pro Single submitter ⚠
- p.Ser8Asn Single submitter ⚠
- p.Thr112Ala Single submitter ⚠
- p.Thr141Met Single submitter ⚠
- p.Thr29Met Single submitter ⚠
- p.Thr375Ile Single submitter ⚠
- p.Thr544Asn Single submitter ⚠
- p.Thr589Ile Single submitter ⚠
- p.Thr715Pro Single submitter ⚠
- p.Thr73Ala Single submitter ⚠
- p.Thr778Pro Single submitter ⚠
- p.Tyr130His Single submitter ⚠
- p.Tyr611His Single submitter ⚠
- p.Val203Met Single submitter ⚠
- p.Val222Ala Single submitter ⚠
- p.Val293Ile Single submitter ⚠
- p.Val332Ile Single submitter ⚠
- p.Val603Ile Single submitter ⚠
- p.Val615Phe Single submitter ⚠
- p.Val636Ala Single submitter ⚠
- p.Val756Ala Single submitter ⚠