CDH22 — 116 ClinVar variants
All ClinVar germline CDH22 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 113 flagged for review →
2 Benign · 2 Likely benign · 112 Uncertain significance
Full CDH22 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 113
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 62
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CDH22 p.Ala121Val Uncertain significance Single submitter
- CDH22 p.Ala15Pro Uncertain significance Single submitter
- CDH22 p.Ala19Thr Uncertain significance Single submitter
- CDH22 p.Ala384Thr Uncertain significance Single submitter
- CDH22 p.Ala450Thr Uncertain significance Single submitter
- CDH22 p.Ala559Thr Uncertain significance Single submitter
- CDH22 p.Ala620Thr Uncertain significance Single submitter
- CDH22 p.Ala620Val Uncertain significance Single submitter
- CDH22 p.Ala710Gly Uncertain significance Single submitter
- CDH22 p.Ala718Gly Uncertain significance Single submitter
- CDH22 p.Ala718Pro Uncertain significance Single submitter
- CDH22 p.Ala827Thr Uncertain significance Single submitter
- CDH22 p.Arg205Gln Uncertain significance Single submitter
- CDH22 p.Arg426Gln Uncertain significance Single submitter
- CDH22 p.Arg4Gly Uncertain significance Single submitter
- CDH22 p.Arg730Leu Uncertain significance Single submitter
- CDH22 p.Arg820Gly Uncertain significance Single submitter
- CDH22 p.Asp325Asn Uncertain significance Single submitter
- CDH22 p.Asp334Asn Uncertain significance Single submitter
- CDH22 p.Asp458Ala Uncertain significance Single submitter
- CDH22 p.Asp491Asn Uncertain significance Single submitter
- CDH22 p.Asp658Glu Uncertain significance Single submitter
- CDH22 p.Asp693His Uncertain significance Single submitter
- CDH22 p.Asp701Glu Uncertain significance Single submitter
- CDH22 p.Gln570Arg Uncertain significance Single submitter
- CDH22 p.Gln771Arg Uncertain significance Single submitter
- CDH22 p.Glu319Asp Uncertain significance Single submitter
- CDH22 p.Glu337Lys Uncertain significance Single submitter
- CDH22 p.Glu571Lys Uncertain significance Single submitter
- CDH22 p.Glu659Gln Uncertain significance Single submitter
- CDH22 p.Glu696Asp Uncertain significance Single submitter
- CDH22 p.Glu6Lys Uncertain significance Single submitter
- CDH22 p.Glu729Gly Uncertain significance Single submitter
- CDH22 p.Glu741Gln Uncertain significance Single submitter
- CDH22 p.Gly324Ser Uncertain significance Single submitter
- CDH22 p.Gly399Ser Uncertain significance Single submitter
- CDH22 p.Gly463Ser Uncertain significance Single submitter
- CDH22 p.Gly703Ser Uncertain significance Single submitter
- CDH22 p.Gly717Ala Uncertain significance Single submitter
- CDH22 p.Gly736Arg Uncertain significance Single submitter
- CDH22 p.His120Arg Uncertain significance Single submitter
- CDH22 p.His354Pro Uncertain significance Single submitter
- CDH22 p.His477Arg Uncertain significance Single submitter
- CDH22 p.His547Tyr Uncertain significance Single submitter
- CDH22 p.His789Pro Uncertain significance Single submitter
- CDH22 p.Ile245Met Uncertain significance Single submitter
- CDH22 p.Ile441Val Uncertain significance Single submitter
- CDH22 p.Ile668Asn Uncertain significance Single submitter
- CDH22 p.Lys98Arg Uncertain significance Single submitter
- CDH22 p.Met312Val Uncertain significance Single submitter
- CDH22 p.Pro18Ser Uncertain significance Single submitter
- CDH22 p.Pro427Leu Uncertain significance Single submitter
- CDH22 p.Ser350Thr Uncertain significance Single submitter
- CDH22 p.Ser732Leu Uncertain significance Single submitter
- CDH22 p.Ser763Leu Uncertain significance Single submitter
- CDH22 p.Thr614Arg Uncertain significance Single submitter
- CDH22 p.Thr680Ala Uncertain significance Single submitter
- CDH22 p.Tyr99His Uncertain significance Single submitter
- CDH22 p.Val299Leu Uncertain significance Single submitter
- CDH22 p.Val356Ala Uncertain significance Single submitter
- CDH22 p.Val356Met Uncertain significance Single submitter
- CDH22 p.Val565Met Uncertain significance Single submitter
Predictors split 51
The independent predictors disagree with each other — read with care.
- CDH22 p.Ala782Val Benign Multiple submitters
- CDH22 p.Ala39Val Uncertain significance Single submitter
- CDH22 p.Ala46Val Uncertain significance Single submitter
- CDH22 p.Ala474Gly Uncertain significance Single submitter
- CDH22 p.Ala49Val Uncertain significance Single submitter
- CDH22 p.Ala505Thr Uncertain significance Single submitter
- CDH22 p.Arg136Trp Uncertain significance Single submitter
- CDH22 p.Arg146Cys Uncertain significance Single submitter
- CDH22 p.Arg368Ser Uncertain significance Single submitter
- CDH22 p.Arg382Cys Uncertain significance Single submitter
- CDH22 p.Arg569Gln Uncertain significance Single submitter
- CDH22 p.Arg62His Uncertain significance Single submitter
- CDH22 p.Arg820Cys Uncertain significance Single submitter
- CDH22 p.Asn545Lys Uncertain significance Single submitter
- CDH22 p.Asp366His Uncertain significance Single submitter
- CDH22 p.Asp822Asn Uncertain significance Single submitter
- CDH22 p.Glu504Lys Uncertain significance Single submitter
- CDH22 p.Gly399Asp Uncertain significance Single submitter
- CDH22 p.Gly399Cys Uncertain significance Single submitter
- CDH22 p.Gly48Val Uncertain significance Single submitter
- CDH22 p.Gly606Ser Uncertain significance Single submitter
- CDH22 p.Gly702Arg Uncertain significance Single submitter
- CDH22 p.Gly702Glu Uncertain significance Single submitter
- CDH22 p.Gly707Ser Uncertain significance Single submitter
- CDH22 p.Gly708Glu Uncertain significance Single submitter
- CDH22 p.Gly711Ser Uncertain significance Single submitter
- CDH22 p.Gly713Asp Uncertain significance Single submitter
- CDH22 p.Gly818Val Uncertain significance Single submitter
- CDH22 p.Leu631Phe Uncertain significance Single submitter
- CDH22 p.Leu788Met Uncertain significance Single submitter
- CDH22 p.Leu788Pro Uncertain significance Single submitter
- CDH22 p.Lys222Thr Uncertain significance Single submitter
- CDH22 p.Met663Ile Uncertain significance Single submitter
- CDH22 p.Met685Leu Uncertain significance Single submitter
- CDH22 p.Pro150Ala Uncertain significance Single submitter
- CDH22 p.Pro278Gln Uncertain significance Single submitter
- CDH22 p.Pro30Thr Uncertain significance Single submitter
- CDH22 p.Pro397Leu Uncertain significance Single submitter
- CDH22 p.Ser350Phe Uncertain significance Single submitter
- CDH22 p.Ser481Thr Uncertain significance Single submitter
- CDH22 p.Ser623Arg Uncertain significance Single submitter
- CDH22 p.Ser714Trp Uncertain significance Single submitter
- CDH22 p.Ser792Leu Uncertain significance Single submitter
- CDH22 p.Thr134Ala Uncertain significance Single submitter
- CDH22 p.Thr185Met Uncertain significance Single submitter
- CDH22 p.Thr355Pro Uncertain significance Single submitter
- CDH22 p.Thr588Ile Uncertain significance Single submitter
- CDH22 p.Val263Ile Uncertain significance Single submitter
- CDH22 p.Val452Met Uncertain significance Single submitter
- CDH22 p.Val574Met Uncertain significance Single submitter
- CDH22 p.Val582Ala Uncertain significance Single submitter
All CDH22 variants
Benign 2
- p.Ala782Val Multiple submitters ⚠
- p.Pro624= Multiple submitters
Likely benign 2
- p.Gly711= Single submitter
- p.Val383Met No assertion criteria EBV-positive nodal T- and NK-cell lymphoma
Uncertain significance 112
- p.Ala121Val Single submitter ⚠
- p.Ala15Pro Single submitter ⚠
- p.Ala19Thr Single submitter ⚠
- p.Ala384Thr Single submitter ⚠
- p.Ala39Val Single submitter ⚠
- p.Ala450Thr Single submitter ⚠
- p.Ala46Val Single submitter ⚠
- p.Ala474Gly Single submitter ⚠
- p.Ala49Val Single submitter ⚠
- p.Ala505Thr Single submitter ⚠
- p.Ala559Thr Single submitter ⚠
- p.Ala620Thr Single submitter ⚠
- p.Ala620Val Single submitter ⚠
- p.Ala710Gly Single submitter ⚠
- p.Ala718Gly Single submitter ⚠
- p.Ala718Pro Single submitter ⚠
- p.Ala827Thr Single submitter ⚠
- p.Arg136Trp Single submitter ⚠
- p.Arg146Cys Single submitter ⚠
- p.Arg205Gln Single submitter ⚠
- p.Arg368Ser Single submitter ⚠
- p.Arg382Cys Single submitter ⚠
- p.Arg426Gln Single submitter ⚠
- p.Arg4Gly Single submitter ⚠
- p.Arg569Gln Single submitter ⚠
- p.Arg62His Single submitter ⚠
- p.Arg730Leu Single submitter ⚠
- p.Arg820Cys Single submitter ⚠
- p.Arg820Gly Single submitter ⚠
- p.Asn545Lys Single submitter ⚠
- p.Asp325Asn Single submitter ⚠
- p.Asp334Asn Single submitter ⚠
- p.Asp366His Single submitter ⚠
- p.Asp458Ala Single submitter ⚠
- p.Asp491Asn Single submitter ⚠
- p.Asp658Glu Single submitter ⚠
- p.Asp693His Single submitter ⚠
- p.Asp701Glu Single submitter ⚠
- p.Asp822Asn Single submitter ⚠
- p.Gln570Arg Single submitter ⚠
- p.Gln771Arg Single submitter ⚠
- p.Glu319Asp Single submitter ⚠
- p.Glu337Lys Single submitter ⚠
- p.Glu504Lys Single submitter ⚠
- p.Glu571Lys Single submitter ⚠
- p.Glu659Gln Single submitter ⚠
- p.Glu696Asp Single submitter ⚠
- p.Glu6Lys Single submitter ⚠
- p.Glu729Gly Single submitter ⚠
- p.Glu741Gln Single submitter ⚠
- p.Gly324Ser Single submitter ⚠
- p.Gly399Asp Single submitter ⚠
- p.Gly399Cys Single submitter ⚠
- p.Gly399Ser Single submitter ⚠
- p.Gly463Ser Single submitter ⚠
- p.Gly48Val Single submitter ⚠
- p.Gly606Ser Single submitter ⚠
- p.Gly702Arg Single submitter ⚠
- p.Gly702Glu Single submitter ⚠
- p.Gly703Ser Single submitter ⚠
- p.Gly707Ser Single submitter ⚠
- p.Gly708Glu Single submitter ⚠
- p.Gly711Ser Single submitter ⚠
- p.Gly713Asp Single submitter ⚠
- p.Gly717Ala Single submitter ⚠
- p.Gly736Arg Single submitter ⚠
- p.Gly818Val Single submitter ⚠
- p.His120Arg Single submitter ⚠
- p.His354Pro Single submitter ⚠
- p.His477Arg Single submitter ⚠
- p.His547Tyr Single submitter ⚠
- p.His789Pro Single submitter ⚠
- p.Ile245Met Single submitter ⚠
- p.Ile441Val Single submitter ⚠
- p.Ile668Asn Single submitter ⚠
- p.Leu631Phe Single submitter ⚠
- p.Leu788Met Single submitter ⚠
- p.Leu788Pro Single submitter ⚠
- p.Lys222Thr Single submitter ⚠
- p.Lys98Arg Single submitter ⚠
- p.Met312Val Single submitter ⚠
- p.Met663Ile Single submitter ⚠
- p.Met685Leu Single submitter ⚠
- p.Pro150Ala Single submitter ⚠
- p.Pro18Ser Single submitter ⚠
- p.Pro278Gln Single submitter ⚠
- p.Pro30Thr Single submitter ⚠
- p.Pro397Leu Single submitter ⚠
- p.Pro427Leu Single submitter ⚠
- p.Ser350Phe Single submitter ⚠
- p.Ser350Thr Single submitter ⚠
- p.Ser481Thr Single submitter ⚠
- p.Ser623Arg Single submitter ⚠
- p.Ser714Trp Single submitter ⚠
- p.Ser732Leu Single submitter ⚠
- p.Ser763Leu Single submitter ⚠
- p.Ser792Leu Single submitter ⚠
- p.Thr134Ala Single submitter ⚠
- p.Thr185Met Single submitter ⚠
- p.Thr355Pro Single submitter ⚠
- p.Thr588Ile Single submitter ⚠
- p.Thr614Arg Single submitter ⚠
- p.Thr680Ala Single submitter ⚠
- p.Tyr99His Single submitter ⚠
- p.Val263Ile Single submitter ⚠
- p.Val299Leu Single submitter ⚠
- p.Val356Ala Single submitter ⚠
- p.Val356Met Single submitter ⚠
- p.Val452Met Single submitter ⚠
- p.Val565Met Single submitter ⚠
- p.Val574Met Single submitter ⚠
- p.Val582Ala Single submitter ⚠