CDH24 — 149 ClinVar variants
All ClinVar germline CDH24 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 146 flagged for review →
5 Likely benign · 144 Uncertain significance
Full CDH24 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 146
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 70
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CDH24 c.1363+418G>T Uncertain significance Single submitter
- CDH24 c.1363+470A>G Uncertain significance Single submitter
- CDH24 c.1363+486C>T Uncertain significance Single submitter
- CDH24 p.Ala119Val Uncertain significance Single submitter
- CDH24 p.Ala174Val Uncertain significance Single submitter
- CDH24 p.Ala398Glu Uncertain significance Single submitter
- CDH24 p.Ala398Thr Uncertain significance Single submitter
- CDH24 p.Ala398Val Uncertain significance Single submitter
- CDH24 p.Ala623Asp Uncertain significance Single submitter
- CDH24 p.Ala623Thr Uncertain significance Single submitter
- CDH24 p.Ala671Gly Uncertain significance Single submitter
- CDH24 p.Ala672Val Uncertain significance Single submitter
- CDH24 p.Ala700Thr Uncertain significance Single submitter
- CDH24 p.Ala780Gly Uncertain significance Single submitter
- CDH24 p.Arg209His Uncertain significance Single submitter
- CDH24 p.Arg20His Uncertain significance Single submitter
- CDH24 p.Arg217Gln Uncertain significance Single submitter
- CDH24 p.Arg26Gln Uncertain significance Single submitter
- CDH24 p.Arg282Gln Uncertain significance Single submitter
- CDH24 p.Arg316Gln Uncertain significance Single submitter
- CDH24 p.Arg32Gln Uncertain significance Single submitter
- CDH24 p.Arg351Gln Uncertain significance Single submitter
- CDH24 p.Arg362His Uncertain significance Single submitter
- CDH24 p.Arg420His Uncertain significance Single submitter
- CDH24 p.Arg505Gly Uncertain significance Single submitter
- CDH24 p.Arg532Gln Uncertain significance Single submitter
- CDH24 p.Arg543His Uncertain significance Single submitter
- CDH24 p.Arg543Pro Uncertain significance Single submitter
- CDH24 p.Arg548Cys Uncertain significance Single submitter
- CDH24 p.Arg548His Uncertain significance Single submitter
- CDH24 p.Arg689Leu Uncertain significance Single submitter
- CDH24 p.Arg733Cys Uncertain significance Single submitter
- CDH24 p.Arg78His Uncertain significance Single submitter
- CDH24 p.Asp176Tyr Uncertain significance Single submitter
- CDH24 p.Asp216Glu Uncertain significance Single submitter
- CDH24 p.Asp254Asn Uncertain significance Single submitter
- CDH24 p.Asp357Tyr Uncertain significance Single submitter
- CDH24 p.Asp471Asn Uncertain significance Single submitter
- CDH24 p.Asp471His Uncertain significance Single submitter
- CDH24 p.Asp649His Uncertain significance Single submitter
- CDH24 p.Asp701Glu Uncertain significance Single submitter
- CDH24 p.Asp723Ala Uncertain significance Single submitter
- CDH24 p.Gln580Glu Uncertain significance Single submitter
- CDH24 p.Gln693Glu Uncertain significance Single submitter
- CDH24 p.Gln704His Uncertain significance Single submitter
- CDH24 p.Gly234Ser Uncertain significance Single submitter
- CDH24 p.Gly301Glu Uncertain significance Single submitter
- CDH24 p.Gly698Ser Uncertain significance Single submitter
- CDH24 p.Gly750Ser Uncertain significance Single submitter
- CDH24 p.Gly754Asp Uncertain significance Single submitter
- CDH24 p.Gly85Arg Uncertain significance Single submitter
- CDH24 p.Gly89Ala Uncertain significance Single submitter
- CDH24 p.His156Arg Uncertain significance Single submitter
- CDH24 p.His415Gln Uncertain significance Single submitter
- CDH24 p.Ile170Asn Uncertain significance Single submitter
- CDH24 p.Ile309Phe Uncertain significance Single submitter
- CDH24 p.Leu765Arg Uncertain significance Single submitter
- CDH24 p.Met633Leu Uncertain significance Single submitter
- CDH24 p.Phe307Cys Uncertain significance Single submitter
- CDH24 p.Pro213Arg Uncertain significance Single submitter
- CDH24 p.Pro37Ser Uncertain significance Single submitter
- CDH24 p.Pro436Thr Uncertain significance Single submitter
- CDH24 p.Pro477Ser Uncertain significance Single submitter
- CDH24 p.Pro758Ser Uncertain significance Single submitter
- CDH24 p.Ser745Ala Uncertain significance Single submitter
- CDH24 p.Trp561Leu Uncertain significance Single submitter
- CDH24 p.Val165Gly Uncertain significance Single submitter
- CDH24 p.Val245Glu Uncertain significance Single submitter
- CDH24 p.Val365Met Uncertain significance Single submitter
- CDH24 p.Val91Ile Uncertain significance Single submitter
Predictors split 76
The independent predictors disagree with each other — read with care.
- CDH24 c.1363+390G>A Uncertain significance Single submitter
- CDH24 c.1363+476G>A Uncertain significance Single submitter
- CDH24 c.1363+476G>T Uncertain significance Single submitter
- CDH24 p.Ala565Val Uncertain significance Single submitter
- CDH24 p.Ala597Thr Likely benign Single submitter
- CDH24 p.Ala603Thr Uncertain significance Single submitter
- CDH24 p.Ala616Gly Uncertain significance Single submitter
- CDH24 p.Ala659Thr Uncertain significance Single submitter
- CDH24 p.Arg124Gln Uncertain significance Single submitter
- CDH24 p.Arg128Trp Uncertain significance Single submitter
- CDH24 p.Arg316Pro Uncertain significance Single submitter
- CDH24 p.Arg323Cys Uncertain significance Single submitter
- CDH24 p.Arg32Trp Uncertain significance Single submitter
- CDH24 p.Arg332Cys Uncertain significance Single submitter
- CDH24 p.Arg337Cys Uncertain significance Single submitter
- CDH24 p.Arg362Cys Uncertain significance Single submitter
- CDH24 p.Arg420Cys Uncertain significance Single submitter
- CDH24 p.Arg43Gln Uncertain significance Single submitter
- CDH24 p.Arg442Cys Uncertain significance Single submitter
- CDH24 p.Arg462Cys Uncertain significance Single submitter
- CDH24 p.Arg501Gln Likely benign Single submitter
- CDH24 p.Arg501Trp Uncertain significance Single submitter
- CDH24 p.Arg578His Uncertain significance Single submitter
- CDH24 p.Arg625Gln Uncertain significance Single submitter
- CDH24 p.Arg626Leu Uncertain significance Single submitter
- CDH24 p.Arg641Gly Uncertain significance Single submitter
- CDH24 p.Arg687Trp Uncertain significance Single submitter
- CDH24 p.Arg74Gln Uncertain significance Single submitter
- CDH24 p.Asn531Ser Uncertain significance Single submitter
- CDH24 p.Asp639Glu Uncertain significance Single submitter
- CDH24 p.Cys737Trp Uncertain significance Single submitter
- CDH24 p.Gln220Lys Uncertain significance Single submitter
- CDH24 p.Gln425Leu Uncertain significance Single submitter
- CDH24 p.Glu427Lys Uncertain significance Single submitter
- CDH24 p.Glu658Lys Uncertain significance Single submitter
- CDH24 p.Gly315Asp Uncertain significance Single submitter
- CDH24 p.Gly315Ser Uncertain significance Single submitter
- CDH24 p.Gly583Ser Uncertain significance Single submitter
- CDH24 p.Gly729Val Uncertain significance Single submitter
- CDH24 p.Gly732Arg Uncertain significance Single submitter
- CDH24 p.Gly750Arg Uncertain significance Single submitter
- CDH24 p.Ile309Met Uncertain significance Single submitter
- CDH24 p.Ile309Val Uncertain significance Single submitter
- CDH24 p.Ile556Thr Uncertain significance Single submitter
- CDH24 p.Leu447Val Uncertain significance Single submitter
- CDH24 p.Lys387Asn Uncertain significance Single submitter
- CDH24 p.Phe266Val Uncertain significance Single submitter
- CDH24 p.Pro129Leu Uncertain significance Single submitter
- CDH24 p.Pro154Leu Uncertain significance Single submitter
- CDH24 p.Pro426Leu Uncertain significance Single submitter
- CDH24 p.Pro564Leu Uncertain significance Single submitter
- CDH24 p.Pro673Ser Uncertain significance Single submitter
- CDH24 p.Pro674Ser Uncertain significance Single submitter
- CDH24 p.Pro686Ser Uncertain significance Single submitter
- CDH24 p.Pro717Arg Uncertain significance Single submitter
- CDH24 p.Pro717Leu Uncertain significance Single submitter
- CDH24 p.Pro764Leu Uncertain significance Single submitter
- CDH24 p.Pro778Ser Uncertain significance Single submitter
- CDH24 p.Pro781Thr Uncertain significance Single submitter
- CDH24 p.Ser106Asn Uncertain significance Single submitter
- CDH24 p.Ser250Gly Uncertain significance Single submitter
- CDH24 p.Ser267Cys Uncertain significance Single submitter
- CDH24 p.Ser297Asn Uncertain significance Single submitter
- CDH24 p.Ser31Phe Uncertain significance Single submitter
- CDH24 p.Ser461Leu Uncertain significance Single submitter
- CDH24 p.Thr248Met Uncertain significance Single submitter
- CDH24 p.Thr341Ile Uncertain significance Single submitter
- CDH24 p.Tyr349Cys Uncertain significance Single submitter
- CDH24 p.Tyr730Cys Uncertain significance Single submitter
- CDH24 p.Val103Leu Uncertain significance Single submitter
- CDH24 p.Val122Met Uncertain significance Single submitter
- CDH24 p.Val358Glu Uncertain significance Single submitter
- CDH24 p.Val393Ile Uncertain significance Single submitter
- CDH24 p.Val463Met Uncertain significance Single submitter
- CDH24 p.Val499Ile Uncertain significance Single submitter
- CDH24 p.Val634Ile Uncertain significance Single submitter
All CDH24 variants
Likely benign 5
- c.1363+461C>T Single submitter
- p.Ala597Thr Single submitter ⚠
- p.Arg501Gln Single submitter ⚠
- p.Glu33Gly Single submitter
- p.Gly718Ser Single submitter
Uncertain significance 144
- c.1363+390G>A Single submitter ⚠
- c.1363+418G>T Single submitter ⚠
- c.1363+470A>G Single submitter ⚠
- c.1363+476G>A Single submitter ⚠
- c.1363+476G>T Single submitter ⚠
- c.1363+486C>T Single submitter ⚠
- p.Ala119Val Single submitter ⚠
- p.Ala174Val Single submitter ⚠
- p.Ala398Glu Single submitter ⚠
- p.Ala398Thr Single submitter ⚠
- p.Ala398Val Single submitter ⚠
- p.Ala565Val Single submitter ⚠
- p.Ala603Thr Single submitter ⚠
- p.Ala616Gly Single submitter ⚠
- p.Ala623Asp Single submitter ⚠
- p.Ala623Thr Single submitter ⚠
- p.Ala659Thr Single submitter ⚠
- p.Ala671Gly Single submitter ⚠
- p.Ala672Val Single submitter ⚠
- p.Ala700Thr Single submitter ⚠
- p.Ala780Gly Single submitter ⚠
- p.Arg124Gln Single submitter ⚠
- p.Arg128Trp Single submitter ⚠
- p.Arg209His Single submitter ⚠
- p.Arg20His Single submitter ⚠
- p.Arg217Gln Single submitter ⚠
- p.Arg26Gln Single submitter ⚠
- p.Arg282Gln Single submitter ⚠
- p.Arg316Gln Single submitter ⚠
- p.Arg316Pro Single submitter ⚠
- p.Arg323Cys Single submitter ⚠
- p.Arg32Gln Single submitter ⚠
- p.Arg32Trp Single submitter ⚠
- p.Arg332Cys Single submitter ⚠
- p.Arg337Cys Single submitter ⚠
- p.Arg351Gln Single submitter ⚠
- p.Arg362Cys Single submitter ⚠
- p.Arg362His Single submitter ⚠
- p.Arg420Cys Single submitter ⚠
- p.Arg420His Single submitter ⚠
- p.Arg43Gln Single submitter ⚠
- p.Arg442Cys Single submitter ⚠
- p.Arg462Cys Single submitter ⚠
- p.Arg501Trp Single submitter ⚠
- p.Arg505Gly Single submitter ⚠
- p.Arg532Gln Single submitter ⚠
- p.Arg543His Single submitter ⚠
- p.Arg543Pro Single submitter ⚠
- p.Arg548Cys Single submitter ⚠
- p.Arg548His Single submitter ⚠
- p.Arg578His Single submitter ⚠
- p.Arg625Gln Single submitter ⚠
- p.Arg626Leu Single submitter ⚠
- p.Arg641Gly Single submitter ⚠
- p.Arg687Trp Single submitter ⚠
- p.Arg689Leu Single submitter ⚠
- p.Arg733Cys Single submitter ⚠
- p.Arg74Gln Single submitter ⚠
- p.Arg78His Single submitter ⚠
- p.Asn531Ser Single submitter ⚠
- p.Asp176Tyr Single submitter ⚠
- p.Asp216Glu Single submitter ⚠
- p.Asp254Asn Single submitter ⚠
- p.Asp357Tyr Single submitter ⚠
- p.Asp471Asn Single submitter ⚠
- p.Asp471His Single submitter ⚠
- p.Asp639Glu Single submitter ⚠
- p.Asp649His Single submitter ⚠
- p.Asp701Glu Single submitter ⚠
- p.Asp723Ala Single submitter ⚠
- p.Cys737Trp Single submitter ⚠
- p.Gln220Lys Single submitter ⚠
- p.Gln425Leu Single submitter ⚠
- p.Gln580Glu Single submitter ⚠
- p.Gln693Glu Single submitter ⚠
- p.Gln704His Single submitter ⚠
- p.Glu427Lys Single submitter ⚠
- p.Glu658Lys Single submitter ⚠
- p.Gly234Ser Single submitter ⚠
- p.Gly301Glu Single submitter ⚠
- p.Gly315Asp Single submitter ⚠
- p.Gly315Ser Single submitter ⚠
- p.Gly583Ser Single submitter ⚠
- p.Gly698Ser Single submitter ⚠
- p.Gly729Val Single submitter ⚠
- p.Gly732Arg Single submitter ⚠
- p.Gly750Arg Single submitter ⚠
- p.Gly750Ser Single submitter ⚠
- p.Gly754Asp Single submitter ⚠
- p.Gly85Arg Single submitter ⚠
- p.Gly89Ala Single submitter ⚠
- p.His156Arg Single submitter ⚠
- p.His415Gln Single submitter ⚠
- p.Ile170Asn Single submitter ⚠
- p.Ile309Met Single submitter ⚠
- p.Ile309Phe Single submitter ⚠
- p.Ile309Val Single submitter ⚠
- p.Ile556Thr Single submitter ⚠
- p.Leu447Val Single submitter ⚠
- p.Leu765Arg Single submitter ⚠
- p.Lys387Asn Single submitter ⚠
- p.Met633Leu Single submitter ⚠
- p.Phe266Val Single submitter ⚠
- p.Phe307Cys Single submitter ⚠
- p.Pro129Leu Single submitter ⚠
- p.Pro154Leu Single submitter ⚠
- p.Pro213Arg Single submitter ⚠
- p.Pro37Ser Single submitter ⚠
- p.Pro426Leu Single submitter ⚠
- p.Pro436Thr Single submitter ⚠
- p.Pro477Ser Single submitter ⚠
- p.Pro564Leu Single submitter ⚠
- p.Pro673Ser Single submitter ⚠
- p.Pro674Ser Single submitter ⚠
- p.Pro686Ser Single submitter ⚠
- p.Pro717Arg Single submitter ⚠
- p.Pro717Leu Single submitter ⚠
- p.Pro758Ser Single submitter ⚠
- p.Pro764Leu Single submitter ⚠
- p.Pro778Ser Single submitter ⚠
- p.Pro781Thr Single submitter ⚠
- p.Ser106Asn Single submitter ⚠
- p.Ser250Gly Single submitter ⚠
- p.Ser267Cys Single submitter ⚠
- p.Ser297Asn Single submitter ⚠
- p.Ser31Phe Single submitter ⚠
- p.Ser461Leu Single submitter ⚠
- p.Ser745Ala Single submitter ⚠
- p.Thr248Met Single submitter ⚠
- p.Thr341Ile Single submitter ⚠
- p.Trp561Leu Single submitter ⚠
- p.Tyr349Cys Single submitter ⚠
- p.Tyr730Cys Single submitter ⚠
- p.Val103Leu Single submitter ⚠
- p.Val122Met Single submitter ⚠
- p.Val165Gly Single submitter ⚠
- p.Val245Glu Single submitter ⚠
- p.Val358Glu Single submitter ⚠
- p.Val365Met Single submitter ⚠
- p.Val393Ile Single submitter ⚠
- p.Val463Met Single submitter ⚠
- p.Val499Ile Single submitter ⚠
- p.Val634Ile Single submitter ⚠
- p.Val91Ile Single submitter ⚠