CDH26 — 160 ClinVar variants

All ClinVar germline CDH26 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 151 flagged for review →

10 Likely benign · 150 Uncertain significance

Full CDH26 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 151

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors lean, ClinVar uncertain 87

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 64

The independent predictors disagree with each other — read with care.

All CDH26 variants

Likely benign 10

p.Ala350Val Single submitter
p.Ala800Thr Single submitter
p.Arg288Gln Single submitter
p.Glu406Lys Single submitter ⚠
p.Gly6Arg Single submitter
p.Gly778Ser Single submitter
p.Pro754Leu Single submitter
p.Ser327Leu Single submitter
p.Val356Ala Single submitter
p.Val447Ala Single submitter

Uncertain significance 150

p.Ala189Gly Single submitter ⚠
p.Ala238Thr Single submitter ⚠
p.Ala274Glu Single submitter ⚠
p.Ala308Ser Single submitter ⚠
p.Ala390Thr Single submitter ⚠
p.Ala598Gly Single submitter ⚠
p.Ala617Asp Single submitter ⚠
p.Ala617Pro Single submitter ⚠
p.Ala623Ser Single submitter ⚠
p.Ala624Ser Single submitter ⚠
p.Ala627Thr Single submitter ⚠
p.Ala665Val Single submitter ⚠
p.Ala690Gly Single submitter ⚠
p.Ala709Val Single submitter ⚠
p.Ala741Pro Single submitter ⚠
p.Ala760Pro Single submitter ⚠
p.Ala793Asp Single submitter ⚠
p.Arg120His Single submitter ⚠
p.Arg139Leu Single submitter ⚠
p.Arg219Trp Single submitter ⚠
p.Arg222Cys Single submitter ⚠
p.Arg248Ser Single submitter ⚠
p.Arg295His Single submitter ⚠
p.Arg348Cys Single submitter ⚠
p.Arg368Lys Single submitter ⚠
p.Arg428Ser Single submitter ⚠
p.Arg505Cys Single submitter ⚠
p.Arg50Gly Single submitter ⚠
p.Arg569Cys Single submitter ⚠
p.Arg682Lys Single submitter ⚠
p.Asn333Ser Single submitter ⚠
p.Asn359Lys Single submitter ⚠
p.Asn496Lys Single submitter ⚠
p.Asn653Ser Single submitter ⚠
p.Asp123Tyr Single submitter ⚠
p.Asp36Glu Single submitter ⚠
p.Asp442Asn Single submitter ⚠
p.Asp442Gly Single submitter ⚠
p.Asp580Asn Single submitter ⚠
p.Asp776Glu Single submitter ⚠
p.Asp776Tyr Single submitter ⚠
p.Cys597Phe Single submitter ⚠
p.Gln178Pro Single submitter ⚠
p.Gln186Leu Single submitter ⚠
p.Gln277His Single submitter ⚠
p.Gln386Arg Single submitter ⚠
p.Gln426Arg Single submitter ⚠
p.Gln47Glu Single submitter ⚠
p.Gln588Glu Single submitter ⚠
p.Gln658Lys Single submitter ⚠
p.Gln711His Single submitter ⚠
p.Gln804Glu Single submitter ⚠
p.Glu109Gly Single submitter ⚠
p.Glu125Gln Single submitter ⚠
p.Glu457Lys Single submitter ⚠
p.Glu511Lys Single submitter ⚠
p.Glu521Lys Single submitter ⚠
p.Glu605Asp Single submitter ⚠
p.Glu666Lys Single submitter ⚠
p.Glu756Lys Single submitter ⚠
p.Glu786Lys Single submitter ⚠
p.Glu803Lys Single submitter ⚠
p.Glu805Val Single submitter ⚠
p.Glu827Gly Single submitter ⚠
p.Gly416Arg Single submitter ⚠
p.Gly552Arg Single submitter ⚠
p.Gly583Glu Single submitter ⚠
p.Gly697Ala Single submitter ⚠
p.Gly76Cys Single submitter ⚠
p.Gly815Ser Single submitter ⚠
p.Gly815Val Single submitter ⚠
p.Gly829Ser Single submitter ⚠
p.His111Arg Single submitter ⚠
p.His119Asp Single submitter ⚠
p.His433Pro Single submitter ⚠
p.His8Tyr Single submitter ⚠
p.Ile103Phe Single submitter ⚠
p.Ile116Thr Single submitter ⚠
p.Ile184Thr Single submitter ⚠
p.Ile184Val Single submitter ⚠
p.Ile245Val Single submitter ⚠
p.Ile315Thr Single submitter ⚠
p.Ile402Phe Single submitter ⚠
p.Ile45Asn Single submitter ⚠
p.Ile45Met Single submitter ⚠
p.Ile45Val Single submitter ⚠
p.Ile578Thr Single submitter ⚠
p.Ile736Thr Single submitter ⚠
p.Ile92Val Single submitter ⚠
p.Leu15Val Single submitter ⚠
p.Leu255Pro Single submitter ⚠
p.Leu294Ser Single submitter ⚠
p.Leu37Ile Single submitter ⚠
p.Leu551Ser Single submitter ⚠
p.Leu632Val Single submitter ⚠
p.Leu78Val Single submitter ⚠
p.Lys376Asn Single submitter ⚠
p.Lys443Arg Single submitter ⚠
p.Met126Ile Single submitter ⚠
p.Met759Thr Single submitter ⚠
p.Met86Val Single submitter ⚠
p.Met89Ile Single submitter ⚠
p.Phe130Ser Single submitter ⚠
p.Phe465Tyr Single submitter ⚠
p.Phe625Ser Single submitter ⚠
p.Pro253Leu Single submitter ⚠
p.Pro342Ala Single submitter ⚠
p.Pro349Ser Single submitter ⚠
p.Pro373Leu Single submitter ⚠
p.Pro398Leu Single submitter ⚠
p.Pro435Leu Single submitter ⚠
p.Pro453Thr Single submitter ⚠
p.Pro479Leu Single submitter ⚠
p.Pro498Arg Single submitter ⚠
p.Pro596Ala Single submitter ⚠
p.Pro781Arg Single submitter ⚠
p.Pro808Ser Single submitter ⚠
p.Pro9Leu Single submitter ⚠
p.Ser148Cys Single submitter ⚠
p.Ser156Asn Single submitter ⚠
p.Ser458Thr Single submitter ⚠
p.Ser585Pro Single submitter ⚠
p.Ser667Gly Single submitter ⚠
p.Ser707Pro Single submitter ⚠
p.Ser785Arg Single submitter ⚠
p.Thr127Ala Single submitter ⚠
p.Thr541Ile Single submitter ⚠
p.Thr59Asn Single submitter ⚠
p.Thr695Met Single submitter ⚠
p.Trp20Arg Single submitter ⚠
p.Trp438Cys Single submitter ⚠
p.Tyr117His Single submitter ⚠
p.Tyr429His Single submitter ⚠
p.Tyr466Cys Single submitter ⚠
p.Tyr742Asn Single submitter ⚠
p.Val137Leu Single submitter ⚠
p.Val293Leu Single submitter ⚠
p.Val293Met Single submitter ⚠
p.Val385Met Single submitter ⚠
p.Val403Phe Single submitter ⚠
p.Val441Ile Single submitter ⚠
p.Val451Met Single submitter ⚠
p.Val473Ala Single submitter ⚠
p.Val497Ile Single submitter ⚠
p.Val559Leu Single submitter ⚠
p.Val590Ala Single submitter ⚠
p.Val661Asp Single submitter ⚠
p.Val755Gly Single submitter ⚠
p.Val755Met Single submitter ⚠
p.Val783Ile Single submitter ⚠