Sugi Variant

Sugi Variant/CDH3

CDH3 — 799 ClinVar variants

All ClinVar germline CDH3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 344 flagged for review →

30 Pathogenic · 2 Pathogenic/Likely pathogenic · 20 Likely pathogenic · 36 Conflicting · 40 Benign · 9 Benign/Likely benign · 285 Likely benign · 377 Uncertain significance

Full CDH3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 344

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors vs ClinVar 1

ClinVar calls these pathogenic, but the computational predictors lean tolerated — the highest-value review flag.

Predictors agree, ClinVar conflicts 5

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 152

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification. · showing the 150 best-reviewed of 152

Predictors split 186

The independent predictors disagree with each other — read with care. · showing the 150 best-reviewed of 186

All CDH3 variants

Pathogenic 30

Pathogenic/Likely pathogenic 2

Likely pathogenic 20

Conflicting classifications of pathogenicity 36

Benign 40

Benign/Likely benign 9

Likely benign 285

Uncertain significance 377

Showing the top 300 by review status; the full set is in the sitemap.