CDH7 — 133 ClinVar variants
All ClinVar germline CDH7 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 95 flagged for review →
36 Benign · 3 Likely benign · 94 Uncertain significance
Full CDH7 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 95
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 39
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CDH7 p.Ala116Thr Uncertain significance Single submitter
- CDH7 p.Arg47Cys Uncertain significance Single submitter
- CDH7 p.Arg47His Uncertain significance Single submitter
- CDH7 p.Arg551Gln Uncertain significance Single submitter
- CDH7 p.Arg631Ile Uncertain significance Single submitter
- CDH7 p.Arg672Lys Uncertain significance Single submitter
- CDH7 p.Arg771Gln Uncertain significance Single submitter
- CDH7 p.Asn258Ile Uncertain significance Single submitter
- CDH7 p.Asp370Asn Uncertain significance Single submitter
- CDH7 p.Asp749Glu Uncertain significance Single submitter
- CDH7 p.Gly549Ser Uncertain significance Single submitter
- CDH7 p.Gly723Asp Uncertain significance Single submitter
- CDH7 p.His515Pro Uncertain significance Single submitter
- CDH7 p.Ile301Val Uncertain significance Single submitter
- CDH7 p.Ile367Thr Uncertain significance Single submitter
- CDH7 p.Ile562Val Uncertain significance Single submitter
- CDH7 p.Ile627Leu Uncertain significance Single submitter
- CDH7 p.Ile646Asn Uncertain significance Single submitter
- CDH7 p.Ile650Phe Uncertain significance Single submitter
- CDH7 p.Leu618Val Uncertain significance Single submitter
- CDH7 p.Lys311Arg Uncertain significance Single submitter
- CDH7 p.Met455Val Uncertain significance Single submitter
- CDH7 p.Met668Val Uncertain significance Single submitter
- CDH7 p.Phe640Leu Uncertain significance Single submitter
- CDH7 p.Phe692Ser Uncertain significance Single submitter
- CDH7 p.Pro383Ala Uncertain significance Single submitter
- CDH7 p.Pro496Gln Uncertain significance Single submitter
- CDH7 p.Pro496Leu Uncertain significance Single submitter
- CDH7 p.Ser512Pro Uncertain significance Single submitter
- CDH7 p.Ser752Arg Uncertain significance Single submitter
- CDH7 p.Thr362Ala Uncertain significance Single submitter
- CDH7 p.Thr687Asn Uncertain significance Single submitter
- CDH7 p.Thr687Ile Uncertain significance Single submitter
- CDH7 p.Val229Ile Uncertain significance Single submitter
- CDH7 p.Val280Ala Uncertain significance Single submitter
- CDH7 p.Val490Ile Uncertain significance Single submitter
- CDH7 p.Val676Ile Uncertain significance Single submitter
- CDH7 p.Val6Leu Uncertain significance Single submitter
- CDH7 p.Val705Ala Uncertain significance Single submitter
Predictors split 56
The independent predictors disagree with each other — read with care.
- CDH7 p.Ala116Gly Uncertain significance Single submitter
- CDH7 p.Ala124Val Uncertain significance Single submitter
- CDH7 p.Ala505Ser Uncertain significance Single submitter
- CDH7 p.Ala598Ser Uncertain significance Single submitter
- CDH7 p.Ala615Gly Uncertain significance Single submitter
- CDH7 p.Arg547Thr Uncertain significance Single submitter
- CDH7 p.Arg551Trp Uncertain significance Single submitter
- CDH7 p.Arg683Trp Uncertain significance Single submitter
- CDH7 p.Asn217Lys Uncertain significance Single submitter
- CDH7 p.Asn536Tyr Uncertain significance Single submitter
- CDH7 p.Asp224His Uncertain significance Single submitter
- CDH7 p.Asp584Asn Uncertain significance Single submitter
- CDH7 p.Asp641Glu Uncertain significance Single submitter
- CDH7 p.Asp756His Uncertain significance Single submitter
- CDH7 p.Asp774Asn Uncertain significance Single submitter
- CDH7 p.Glu296Val Uncertain significance Single submitter
- CDH7 p.Glu317Lys Uncertain significance Single submitter
- CDH7 p.Glu554Lys Uncertain significance Single submitter
- CDH7 p.Glu781Gln Uncertain significance Single submitter
- CDH7 p.Leu353Pro Uncertain significance Single submitter
- CDH7 p.Leu355Ser Uncertain significance Single submitter
- CDH7 p.Leu544Arg Uncertain significance Single submitter
- CDH7 p.Leu578Val Uncertain significance Single submitter
- CDH7 p.Leu621Phe Uncertain significance Single submitter
- CDH7 p.Leu625Phe Uncertain significance Single submitter
- CDH7 p.Leu674Pro Uncertain significance Single submitter
- CDH7 p.Lys46Thr Uncertain significance Single submitter
- CDH7 p.Lys634Glu Uncertain significance Single submitter
- CDH7 p.Lys635Arg Uncertain significance Single submitter
- CDH7 p.Met384Val Uncertain significance Single submitter
- CDH7 p.Met630Thr Uncertain significance Single submitter
- CDH7 p.Pro276Thr Uncertain significance Single submitter
- CDH7 p.Pro637Thr Uncertain significance Single submitter
- CDH7 p.Pro722Ser Uncertain significance Single submitter
- CDH7 p.Ser387Leu Uncertain significance Single submitter
- CDH7 p.Ser406Tyr Uncertain significance Single submitter
- CDH7 p.Ser569Tyr Uncertain significance Single submitter
- CDH7 p.Ser755Phe Uncertain significance Single submitter
- CDH7 p.Ser93Cys Uncertain significance Single submitter
- CDH7 p.Thr159Ala Uncertain significance Single submitter
- CDH7 p.Thr159Met Uncertain significance Single submitter
- CDH7 p.Thr245Ile Uncertain significance Single submitter
- CDH7 p.Thr253Ser Uncertain significance Single submitter
- CDH7 p.Thr318Asn Uncertain significance Single submitter
- CDH7 p.Thr338Met Uncertain significance Single submitter
- CDH7 p.Thr361Met Uncertain significance Single submitter
- CDH7 p.Thr593Ala Uncertain significance Single submitter
- CDH7 p.Thr629Ser Uncertain significance Single submitter
- CDH7 p.Tyr267Cys Uncertain significance Single submitter
- CDH7 p.Tyr269Cys Uncertain significance Single submitter
- CDH7 p.Val133Met Uncertain significance Single submitter
- CDH7 p.Val371Ile Uncertain significance Single submitter
- CDH7 p.Val557Ile Benign Single submitter
- CDH7 p.Val565Gly Uncertain significance Single submitter
- CDH7 p.Val600Asp Uncertain significance Single submitter
- CDH7 p.Val622Gly Uncertain significance Single submitter
All CDH7 variants
Benign 36
- c.1612+22C>T Multiple submitters
- c.1612+24A>T Multiple submitters
- c.1612+81T>C Multiple submitters
- c.1864+225A>G Multiple submitters
- c.210+52G>A Multiple submitters
- c.210+56T>G Multiple submitters
- c.626-74C>T Multiple submitters
- c.794-83A>G Multiple submitters
- c.-173C>A Multiple submitters
- p.Asn576Ser Multiple submitters
- p.Asp126= Multiple submitters
- p.Asp370= Multiple submitters
- p.Glu28= Multiple submitters
- p.Gly88= Multiple submitters
- p.Leu17= Multiple submitters
- p.Pro163= Multiple submitters
- p.Pro200= Multiple submitters
- p.Thr159= Multiple submitters
- p.Val229= Multiple submitters
- p.Val617= Multiple submitters
- c.1372+312G>A Single submitter
- c.1373-226T>C Single submitter
- c.1495-300G>A Single submitter
- c.1612+188T>A Single submitter
- c.1612+296A>G Single submitter
- c.210+205A>G Single submitter
- c.211-130C>T Single submitter
- c.506-307A>T Single submitter
- c.626-158C>A Single submitter
- c.626-303A>G Single submitter
- c.793+177G>A Single submitter
- c.981+106del Single submitter
- c.981+132A>G Single submitter
- c.982-228G>A Single submitter
- p.Lys2= Single submitter
- p.Val557Ile Single submitter ⚠
Likely benign 3
- c.1495-5C>G Single submitter
- p.Ser387= Single submitter
- p.Tyr118= Single submitter
Uncertain significance 94
- p.Ala116Gly Single submitter ⚠
- p.Ala116Thr Single submitter ⚠
- p.Ala124Val Single submitter ⚠
- p.Ala505Ser Single submitter ⚠
- p.Ala598Ser Single submitter ⚠
- p.Ala615Gly Single submitter ⚠
- p.Arg47Cys Single submitter ⚠
- p.Arg47His Single submitter ⚠
- p.Arg547Thr Single submitter ⚠
- p.Arg551Gln Single submitter ⚠
- p.Arg551Trp Single submitter ⚠
- p.Arg631Ile Single submitter ⚠
- p.Arg672Lys Single submitter ⚠
- p.Arg683Trp Single submitter ⚠
- p.Arg771Gln Single submitter ⚠
- p.Asn217Lys Single submitter ⚠
- p.Asn258Ile Single submitter ⚠
- p.Asn536Tyr Single submitter ⚠
- p.Asp224His Single submitter ⚠
- p.Asp370Asn Single submitter ⚠
- p.Asp584Asn Single submitter ⚠
- p.Asp641Glu Single submitter ⚠
- p.Asp749Glu Single submitter ⚠
- p.Asp756His Single submitter ⚠
- p.Asp774Asn Single submitter ⚠
- p.Glu296Val Single submitter ⚠
- p.Glu317Lys Single submitter ⚠
- p.Glu554Lys Single submitter ⚠
- p.Glu781Gln Single submitter ⚠
- p.Gly549Ser Single submitter ⚠
- p.Gly723Asp Single submitter ⚠
- p.His515Pro Single submitter ⚠
- p.Ile301Val Single submitter ⚠
- p.Ile367Thr Single submitter ⚠
- p.Ile562Val Single submitter ⚠
- p.Ile627Leu Single submitter ⚠
- p.Ile646Asn Single submitter ⚠
- p.Ile650Phe Single submitter ⚠
- p.Leu353Pro Single submitter ⚠
- p.Leu355Ser Single submitter ⚠
- p.Leu544Arg Single submitter ⚠
- p.Leu578Val Single submitter ⚠
- p.Leu618Val Single submitter ⚠
- p.Leu621Phe Single submitter ⚠
- p.Leu625Phe Single submitter ⚠
- p.Leu674Pro Single submitter ⚠
- p.Lys311Arg Single submitter ⚠
- p.Lys46Thr Single submitter ⚠
- p.Lys634Glu Single submitter ⚠
- p.Lys635Arg Single submitter ⚠
- p.Met384Val Single submitter ⚠
- p.Met455Val Single submitter ⚠
- p.Met630Thr Single submitter ⚠
- p.Met668Val Single submitter ⚠
- p.Phe640Leu Single submitter ⚠
- p.Phe692Ser Single submitter ⚠
- p.Pro276Thr Single submitter ⚠
- p.Pro383Ala Single submitter ⚠
- p.Pro496Gln Single submitter ⚠
- p.Pro496Leu Single submitter ⚠
- p.Pro637Thr Single submitter ⚠
- p.Pro722Ser Single submitter ⚠
- p.Ser387Leu Single submitter ⚠
- p.Ser406Tyr Single submitter ⚠
- p.Ser512Pro Single submitter ⚠
- p.Ser569Tyr Single submitter ⚠
- p.Ser752Arg Single submitter ⚠
- p.Ser755Phe Single submitter ⚠
- p.Ser93Cys Single submitter ⚠
- p.Thr159Ala Single submitter ⚠
- p.Thr159Met Single submitter ⚠
- p.Thr245Ile Single submitter ⚠
- p.Thr253Ser Single submitter ⚠
- p.Thr318Asn Single submitter ⚠
- p.Thr338Met Single submitter ⚠
- p.Thr361Met Single submitter ⚠
- p.Thr362Ala Single submitter ⚠
- p.Thr593Ala Single submitter ⚠
- p.Thr629Ser Single submitter ⚠
- p.Thr687Asn Single submitter ⚠
- p.Thr687Ile Single submitter ⚠
- p.Tyr267Cys Single submitter ⚠
- p.Tyr269Cys Single submitter ⚠
- p.Val133Met Single submitter ⚠
- p.Val229Ile Single submitter ⚠
- p.Val280Ala Single submitter ⚠
- p.Val371Ile Single submitter ⚠
- p.Val490Ile Single submitter ⚠
- p.Val565Gly Single submitter ⚠
- p.Val600Asp Single submitter ⚠
- p.Val622Gly Single submitter ⚠
- p.Val676Ile Single submitter ⚠
- p.Val6Leu Single submitter ⚠
- p.Val705Ala Single submitter ⚠