CDH9 — 91 ClinVar variants

All ClinVar germline CDH9 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 87 flagged for review →

3 Benign · 2 Likely benign · 86 Uncertain significance

Full CDH9 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 87

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors lean, ClinVar uncertain 42

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 45

The independent predictors disagree with each other — read with care.

All CDH9 variants

Benign 3

p.Glu603Gly Multiple submitters ⚠
p.Pro486= Multiple submitters
p.Asp336Asn Single submitter ⚠

Likely benign 2

p.Gln231= Single submitter
p.Gln274= Single submitter

Uncertain significance 86

p.Arg53Cys Multiple submitters ⚠
p.Ala186Thr Single submitter ⚠
p.Ala412Ser Single submitter ⚠
p.Ala445Gly Single submitter ⚠
p.Ala500Glu Single submitter ⚠
p.Arg137Gln Single submitter ⚠
p.Arg519Gln Single submitter ⚠
p.Arg552Gln Single submitter ⚠
p.Arg558His Single submitter ⚠
p.Arg587His Single submitter ⚠
p.Arg773His Single submitter ⚠
p.Arg773Leu Single submitter ⚠
p.Asn190Ser Single submitter ⚠
p.Asn573Asp Single submitter ⚠
p.Asn573Tyr Single submitter ⚠
p.Asn655Asp Single submitter ⚠
p.Asn660Ser Single submitter ⚠
p.Asp317Glu Single submitter ⚠
p.Asp355Glu Single submitter ⚠
p.Asp661Asn Single submitter ⚠
p.Asp70Gly Single submitter ⚠
p.Asp763Asn Single submitter ⚠
p.Asp779Val Single submitter ⚠
p.Asp785Gly Single submitter ⚠
p.Asp85Glu Single submitter ⚠
p.Gln231Lys Single submitter ⚠
p.Gln325Lys Single submitter ⚠
p.Gln713His Single submitter ⚠
p.Glu144Lys Single submitter ⚠
p.Glu643Asp Single submitter ⚠
p.Glu722Gln Single submitter ⚠
p.Glu741Gln Single submitter ⚠
p.Gly298Trp Single submitter ⚠
p.Gly610Ser Single submitter ⚠
p.Gly610Val Single submitter ⚠
p.Gly86Glu Single submitter ⚠
p.His717Arg Single submitter ⚠
p.Ile146Val Single submitter ⚠
p.Ile147Val Single submitter ⚠
p.Ile201Val Single submitter ⚠
p.Ile216Val Single submitter ⚠
p.Ile481Lys Single submitter ⚠
p.Ile674Val Single submitter ⚠
p.Leu389Trp Single submitter ⚠
p.Leu443Trp Single submitter ⚠
p.Leu616Val Single submitter ⚠
p.Leu688Phe Single submitter ⚠
p.Leu767Phe Single submitter ⚠
p.Lys365Arg Single submitter ⚠
p.Lys365Glu Single submitter ⚠
p.Lys371Thr Single submitter ⚠
p.Lys514Asn Single submitter ⚠
p.Lys637Met Single submitter ⚠
p.Met15Ile Single submitter ⚠
p.Met47Lys Single submitter ⚠
p.Phe16Leu Single submitter ⚠
p.Phe495Leu Single submitter ⚠
p.Phe571Val Single submitter ⚠
p.Pro141Ser Single submitter ⚠
p.Pro567Leu Single submitter ⚠
p.Pro772Thr Single submitter ⚠
p.Ser194Gly Single submitter ⚠
p.Ser34Asn Single submitter ⚠
p.Ser470Asn Single submitter ⚠
p.Ser599Pro Single submitter ⚠
p.Ser751Thr Single submitter ⚠
p.Thr13Asn Single submitter ⚠
p.Thr257Lys Single submitter ⚠
p.Thr272Met Single submitter ⚠
p.Thr384Ala Single submitter ⚠
p.Thr3Ile Single submitter ⚠
p.Thr41Ile Single submitter ⚠
p.Thr459Lys Single submitter ⚠
p.Thr69Ser Single submitter ⚠
p.Trp707Gly Single submitter ⚠
p.Tyr14Cys Single submitter ⚠
p.Tyr164His Single submitter ⚠
p.Tyr207Cys Single submitter ⚠
p.Tyr305Asp Single submitter ⚠
p.Tyr343Cys Single submitter ⚠
p.Tyr73Cys Single submitter ⚠
p.Val235Ala Single submitter ⚠
p.Val261Ile Single submitter ⚠
p.Val396Ala Single submitter ⚠
p.Val421Ala Single submitter ⚠
p.Ser734= No assertion criteria