CDHR5 — 202 ClinVar variants

All ClinVar germline CDHR5 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 188 flagged for review →

2 Benign · 16 Likely benign · 184 Uncertain significance

Full CDHR5 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 188

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors lean, ClinVar uncertain 71

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 117

The independent predictors disagree with each other — read with care.

All CDHR5 variants

Benign 2

p.Arg182His Multiple submitters
p.Gly298= Multiple submitters

Likely benign 16

p.Ala808Thr Single submitter
p.Arg189Gln Single submitter ⚠
p.Arg196Trp Single submitter ⚠
p.Asp278= Single submitter
p.Glu195Lys Single submitter
p.Gly751Ser Single submitter
p.Gly757Ser Single submitter
p.His734Pro Single submitter
p.Pro351Leu Single submitter ⚠
p.Pro706Leu Single submitter ⚠
p.Pro742= Single submitter
p.Pro761Ser Single submitter
p.Ser585Gly Single submitter
p.Tyr174Phe Single submitter
p.Val315Ile Single submitter
p.Val688Ile Single submitter

Uncertain significance 184

p.Ala151Pro Single submitter ⚠
p.Ala171Thr Single submitter ⚠
p.Ala230Thr Single submitter ⚠
p.Ala347Val Single submitter ⚠
p.Ala364Val Single submitter ⚠
p.Ala369Val Single submitter ⚠
p.Ala398Thr Single submitter ⚠
p.Ala430Thr Single submitter ⚠
p.Ala443Val Single submitter ⚠
p.Ala533Gly Single submitter ⚠
p.Ala669Val Single submitter ⚠
p.Ala670Asp Single submitter ⚠
p.Ala677Val Single submitter ⚠
p.Ala717Val Single submitter ⚠
p.Ala727Thr Single submitter ⚠
p.Ala727Val Single submitter ⚠
p.Ala739Thr Single submitter ⚠
p.Ala739Val Single submitter ⚠
p.Ala745Thr Single submitter ⚠
p.Ala764Val Single submitter ⚠
p.Ala765Asp Single submitter ⚠
p.Ala765Gly Single submitter ⚠
p.Ala790Val Single submitter ⚠
p.Ala808Val Single submitter ⚠
p.Ala828Thr Single submitter ⚠
p.Ala828Val Single submitter ⚠
p.Arg154His Single submitter ⚠
p.Arg189Trp Single submitter ⚠
p.Arg196Gln Single submitter ⚠
p.Arg206Gln Single submitter ⚠
p.Arg270Cys Single submitter ⚠
p.Arg281Cys Single submitter ⚠
p.Arg334Cys Single submitter ⚠
p.Arg334His Single submitter ⚠
p.Arg353His Single submitter ⚠
p.Arg360His Single submitter ⚠
p.Arg662Cys Single submitter ⚠
p.Arg662His Single submitter ⚠
p.Arg72Gln Single submitter ⚠
p.Arg72Pro Single submitter ⚠
p.Arg72Trp Single submitter ⚠
p.Arg782Trp Single submitter ⚠
p.Arg783Gln Single submitter ⚠
p.Asn181Ser Single submitter ⚠
p.Asn308Asp Single submitter ⚠
p.Asn526Tyr Single submitter ⚠
p.Asn715Lys Single submitter ⚠
p.Asp158Asn Single submitter ⚠
p.Asp173Asn Single submitter ⚠
p.Asp244His Single submitter ⚠
p.Asp331Asn Single submitter ⚠
p.Asp51Tyr Single submitter ⚠
p.Asp735Asn Single submitter ⚠
p.Asp735Val Single submitter ⚠
p.Asp814Gly Single submitter ⚠
p.Asp823Asn Single submitter ⚠
p.Cys701Trp Single submitter ⚠
p.Gln148His Single submitter ⚠
p.Gln285Arg Single submitter ⚠
p.Gln450Lys Single submitter ⚠
p.Gln549Arg Single submitter ⚠
p.Gln77Lys Single submitter ⚠
p.Glu135Lys Single submitter ⚠
p.Glu448Lys Single submitter ⚠
p.Glu56Gln Single submitter ⚠
p.Glu59Lys Single submitter ⚠
p.Glu659Asp Single submitter ⚠
p.Glu785Gly Single submitter ⚠
p.Glu795Lys Single submitter ⚠
p.Glu800Gln Single submitter ⚠
p.Glu826Lys Single submitter ⚠
p.Gly255Arg Single submitter ⚠
p.Gly260Glu Single submitter ⚠
p.Gly272Arg Single submitter ⚠
p.Gly282Ser Single submitter ⚠
p.Gly413Arg Single submitter ⚠
p.Gly413Glu Single submitter ⚠
p.Gly546Ala Single submitter ⚠
p.Gly554Ala Single submitter ⚠
p.Gly568Arg Single submitter ⚠
p.Gly569Ser Single submitter ⚠
p.Gly587Glu Single submitter ⚠
p.Gly598Ser Single submitter ⚠
p.Gly608Arg Single submitter ⚠
p.Gly63Ala Single submitter ⚠
p.Gly656Asp Single submitter ⚠
p.Gly656Ser Single submitter ⚠
p.Gly672Asp Single submitter ⚠
p.Gly673Val Single submitter ⚠
p.Gly676Ser Single submitter ⚠
p.Gly769Arg Single submitter ⚠
p.Gly786Ser Single submitter ⚠
p.Gly822Ser Single submitter ⚠
p.Gly839Ser Single submitter ⚠
p.Ile36Met Single submitter ⚠
p.Ile447Thr Single submitter ⚠
p.Leu204Pro Single submitter ⚠
p.Leu309Phe Single submitter ⚠
p.Leu332Pro Single submitter ⚠
p.Leu689Val Single submitter ⚠
p.Leu778Pro Single submitter ⚠
p.Lys737Asn Single submitter ⚠
p.Lys789Glu Single submitter ⚠
p.Met199Val Single submitter ⚠
p.Met24Ile Single submitter ⚠
p.Met319Ile Single submitter ⚠
p.Met613Ile Single submitter ⚠
p.Phe175Val Single submitter ⚠
p.Pro10Arg Single submitter ⚠
p.Pro145Leu Single submitter ⚠
p.Pro209Leu Single submitter ⚠
p.Pro21Arg Single submitter ⚠
p.Pro239Leu Single submitter ⚠
p.Pro351Ala Single submitter ⚠
p.Pro463Gln Single submitter ⚠
p.Pro473His Single submitter ⚠
p.Pro484Ser Single submitter ⚠
p.Pro485Ala Single submitter ⚠
p.Pro48Leu Single submitter ⚠
p.Pro491His Single submitter ⚠
p.Pro505Leu Single submitter ⚠
p.Pro543Ala Single submitter ⚠
p.Pro581Leu Single submitter ⚠
p.Pro594Ala Single submitter ⚠
p.Pro597Leu Single submitter ⚠
p.Pro612Leu Single submitter ⚠
p.Pro645Ser Single submitter ⚠
p.Pro68His Single submitter ⚠
p.Pro720Ser Single submitter ⚠
p.Pro730His Single submitter ⚠
p.Pro755Ser Single submitter ⚠
p.Ser265Phe Single submitter ⚠
p.Ser306Trp Single submitter ⚠
p.Ser393Leu Single submitter ⚠
p.Ser407Leu Single submitter ⚠
p.Ser515Leu Single submitter ⚠
p.Ser548Phe Single submitter ⚠
p.Ser585Arg Single submitter ⚠
p.Ser649Gly Single submitter ⚠
p.Ser658Leu Single submitter ⚠
p.Ser731Arg Single submitter ⚠
p.Thr137Met Single submitter ⚠
p.Thr147Arg Single submitter ⚠
p.Thr147Met Single submitter ⚠
p.Thr218Ile Single submitter ⚠
p.Thr222Ser Single submitter ⚠
p.Thr241Ile Single submitter ⚠
p.Thr259Met Single submitter ⚠
p.Thr419Asn Single submitter ⚠
p.Thr470Lys Single submitter ⚠
p.Thr477Ile Single submitter ⚠
p.Thr478Ala Single submitter ⚠
p.Thr493Lys Single submitter ⚠
p.Thr508Ile Single submitter ⚠
p.Thr514Asn Single submitter ⚠
p.Thr517Ile Single submitter ⚠
p.Thr517Lys Single submitter ⚠
p.Thr528Ile Single submitter ⚠
p.Thr542Asn Single submitter ⚠
p.Thr559Ala Single submitter ⚠
p.Thr570Ile Single submitter ⚠
p.Thr626Pro Single submitter ⚠
p.Thr733Met Single submitter ⚠
p.Thr772Lys Single submitter ⚠
p.Thr779Asn Single submitter ⚠
p.Tyr86Asn Single submitter ⚠
p.Val105Met Single submitter ⚠
p.Val112Met Single submitter ⚠
p.Val133Ala Single submitter ⚠
p.Val143Ile Single submitter ⚠
p.Val257Ala Single submitter ⚠
p.Val296Met Single submitter ⚠
p.Val325Leu Single submitter ⚠
p.Val342Met Single submitter ⚠
p.Val372Leu Single submitter ⚠
p.Val373Ala Single submitter ⚠
p.Val39Glu Single submitter ⚠
p.Val415Ile Single submitter ⚠
p.Val481Ile Single submitter ⚠
p.Val54Ile Single submitter ⚠
p.Val729Ile Single submitter ⚠
p.Val791Gly Single submitter ⚠
p.Val803Met Single submitter ⚠
p.Val82Glu Single submitter ⚠