CDIP1 — 34 ClinVar variants
All ClinVar germline CDIP1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 30 flagged for review →
4 Likely benign · 30 Uncertain significance
Full CDIP1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 30
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 16
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CDIP1 p.Ala122Thr Uncertain significance Single submitter
- CDIP1 p.Ala136Ser Uncertain significance Single submitter
- CDIP1 p.Ala34Gly Uncertain significance Single submitter
- CDIP1 p.Arg30His Uncertain significance Single submitter
- CDIP1 p.Asp48Asn Uncertain significance Single submitter
- CDIP1 p.Asp74His Uncertain significance Single submitter
- CDIP1 p.Gln37Leu Uncertain significance Single submitter
- CDIP1 p.Gly172Arg Uncertain significance Single submitter
- CDIP1 p.His89Pro Uncertain significance Single submitter
- CDIP1 p.Ile132Met Uncertain significance Single submitter
- CDIP1 p.Ile49Thr Uncertain significance Single submitter
- CDIP1 p.Leu44Arg Uncertain significance Single submitter
- CDIP1 p.Pro28Ala Uncertain significance Single submitter
- CDIP1 p.Thr101Met Uncertain significance Single submitter
- CDIP1 p.Thr14Ala Uncertain significance Single submitter
- CDIP1 p.Tyr9Cys Uncertain significance Single submitter
Predictors split 14
The independent predictors disagree with each other — read with care.
- CDIP1 p.Leu18Pro Uncertain significance Single submitter
- CDIP1 p.Pro106Thr Uncertain significance Single submitter
- CDIP1 p.Pro108Ser Uncertain significance Single submitter
- CDIP1 p.Pro108Thr Uncertain significance Single submitter
- CDIP1 p.Pro13Leu Uncertain significance Single submitter
- CDIP1 p.Pro43Leu Uncertain significance Single submitter
- CDIP1 p.Pro51Ser Uncertain significance Single submitter
- CDIP1 p.Pro64His Uncertain significance Single submitter
- CDIP1 p.Pro7Ala Uncertain significance Single submitter
- CDIP1 p.Pro96Ser Uncertain significance Single submitter
- CDIP1 p.Pro97Thr Uncertain significance Single submitter
- CDIP1 p.Ser196Arg Uncertain significance Single submitter
- CDIP1 p.Thr101Lys Uncertain significance Single submitter
- CDIP1 p.Val163Met Uncertain significance Single submitter
All CDIP1 variants
Likely benign 4
- c.*103C>T Single submitter
- p.Met61Val Single submitter
- p.Ser72Asn Single submitter
- p.Tyr155= No assertion criteria EBV-positive nodal T- and NK-cell lymphoma
Uncertain significance 30
- p.Ala122Thr Single submitter ⚠
- p.Ala136Ser Single submitter ⚠
- p.Ala34Gly Single submitter ⚠
- p.Arg30His Single submitter ⚠
- p.Asp48Asn Single submitter ⚠
- p.Asp74His Single submitter ⚠
- p.Gln37Leu Single submitter ⚠
- p.Gly172Arg Single submitter ⚠
- p.His89Pro Single submitter ⚠
- p.Ile132Met Single submitter ⚠
- p.Ile49Thr Single submitter ⚠
- p.Leu18Pro Single submitter ⚠
- p.Leu44Arg Single submitter ⚠
- p.Pro106Thr Single submitter ⚠
- p.Pro108Ser Single submitter ⚠
- p.Pro108Thr Single submitter ⚠
- p.Pro13Leu Single submitter ⚠
- p.Pro28Ala Single submitter ⚠
- p.Pro43Leu Single submitter ⚠
- p.Pro51Ser Single submitter ⚠
- p.Pro64His Single submitter ⚠
- p.Pro7Ala Single submitter ⚠
- p.Pro96Ser Single submitter ⚠
- p.Pro97Thr Single submitter ⚠
- p.Ser196Arg Single submitter ⚠
- p.Thr101Lys Single submitter ⚠
- p.Thr101Met Single submitter ⚠
- p.Thr14Ala Single submitter ⚠
- p.Tyr9Cys Single submitter ⚠
- p.Val163Met Single submitter ⚠