CDK1 — 11 ClinVar variants
All ClinVar germline CDK1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 10 flagged for review →
1 Benign · 10 Uncertain significance
Full CDK1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 10
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 8
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CDK1 p.Arg215Lys Uncertain significance Single submitter
- CDK1 p.His23Asn Uncertain significance Single submitter
- CDK1 p.Ile157Leu Uncertain significance Single submitter
- CDK1 p.Ile157Val Uncertain significance Single submitter
- CDK1 p.Ile190Val Uncertain significance Single submitter
- CDK1 p.Leu70Val Uncertain significance Single submitter
- CDK1 p.Lys279Arg Uncertain significance Single submitter
- CDK1 p.Ser248Asn Uncertain significance Single submitter
Predictors split 2
The independent predictors disagree with each other — read with care.
All CDK1 variants
Benign 1
- p.Phe214= Single submitter
Uncertain significance 10
- p.Arg215Lys Single submitter ⚠
- p.Gln28Arg Single submitter ⚠
- p.His23Asn Single submitter ⚠
- p.Ile157Leu Single submitter ⚠
- p.Ile157Val Single submitter ⚠
- p.Ile190Val Single submitter ⚠
- p.Leu70Val Single submitter ⚠
- p.Lys279Arg Single submitter ⚠
- p.Ser121Thr Single submitter ⚠
- p.Ser248Asn Single submitter ⚠