Sugi Variant

Sugi Variant/CDK10

CDK10 — 159 ClinVar variants

All ClinVar germline CDK10 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 81 flagged for review →

13 Pathogenic · 6 Pathogenic/Likely pathogenic · 13 Likely pathogenic · 6 Conflicting · 4 Benign · 30 Likely benign · 87 Uncertain significance

Full CDK10 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 81

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors vs ClinVar 1

ClinVar calls these pathogenic, but the computational predictors lean tolerated — the highest-value review flag.

Predictors agree, ClinVar conflicts 2

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 63

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 15

The independent predictors disagree with each other — read with care.

All CDK10 variants

Pathogenic 13

Pathogenic/Likely pathogenic 6

  • c.609-1G>A Multiple submitters Al Kaissi syndrome
  • c.87+5G>A Multiple submitters Al Kaissi syndrome
  • p.Cys8Ter Multiple submitters Al Kaissi syndrome
  • p.Glu244fs Multiple submitters Al Kaissi syndrome
  • p.Lys174fs Multiple submitters Al Kaissi syndrome
  • p.Trp291fs Multiple submitters Inborn genetic diseases

Likely pathogenic 13

Conflicting classifications of pathogenicity 6

Benign 4

Likely benign 30

Uncertain significance 87