CDK11A — 130 ClinVar variants
All ClinVar germline CDK11A variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 110 flagged for review →
9 Likely benign · 121 Uncertain significance
Full CDK11A gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 110
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 71
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CDK11A p.Arg247Gln Uncertain significance Multiple submitters
- CDK11A p.Ala196Val Uncertain significance Single submitter
- CDK11A p.Ala558Thr Uncertain significance Single submitter
- CDK11A p.Arg132Gln Uncertain significance Single submitter
- CDK11A p.Arg132Trp Uncertain significance Single submitter
- CDK11A p.Arg134Gln Uncertain significance Single submitter
- CDK11A p.Arg161Lys Uncertain significance Single submitter
- CDK11A p.Arg180Gln Uncertain significance Single submitter
- CDK11A p.Arg348Gln Uncertain significance Single submitter
- CDK11A p.Arg364Gln Uncertain significance Single submitter
- CDK11A p.Arg41Gln Uncertain significance Single submitter
- CDK11A p.Arg41Trp Uncertain significance Single submitter
- CDK11A p.Arg439Lys Uncertain significance Single submitter
- CDK11A p.Arg45Gln Uncertain significance Single submitter
- CDK11A p.Arg546His Uncertain significance Single submitter
- CDK11A p.Arg570Gln Uncertain significance Single submitter
- CDK11A p.Arg570Trp Uncertain significance Single submitter
- CDK11A p.Arg589His Uncertain significance Single submitter
- CDK11A p.Asn350Ile Uncertain significance Single submitter
- CDK11A p.Asp140Gly Uncertain significance Single submitter
- CDK11A p.Asp345Asn Uncertain significance Single submitter
- CDK11A p.Asp363Asn Uncertain significance Single submitter
- CDK11A p.Asp394Glu Uncertain significance Single submitter
- CDK11A p.Cys57Ser Uncertain significance Single submitter
- CDK11A p.Gln182His Uncertain significance Single submitter
- CDK11A p.Glu130Lys Uncertain significance Single submitter
- CDK11A p.Glu336Val Uncertain significance Single submitter
- CDK11A p.Glu368Lys Uncertain significance Single submitter
- CDK11A p.Glu402Gln Uncertain significance Single submitter
- CDK11A p.Glu402Gly Uncertain significance Single submitter
- CDK11A p.Glu402Lys Uncertain significance Single submitter
- CDK11A p.Glu461Asp Uncertain significance Single submitter
- CDK11A p.Glu50Asp Uncertain significance Single submitter
- CDK11A p.Gly491Ser Uncertain significance Single submitter
- CDK11A p.Gly567Glu Uncertain significance Single submitter
- CDK11A p.Gly610Ala Uncertain significance Single submitter
- CDK11A p.Gly614Glu Uncertain significance Single submitter
- CDK11A p.Gly674Ala Uncertain significance Single submitter
- CDK11A p.His506Gln Uncertain significance Single submitter
- CDK11A p.Ile488Thr Uncertain significance Single submitter
- CDK11A p.Ile497Asn Uncertain significance Single submitter
- CDK11A p.Ile543Asn Uncertain significance Single submitter
- CDK11A p.Lys101Arg Uncertain significance Single submitter
- CDK11A p.Lys120Thr Uncertain significance Single submitter
- CDK11A p.Lys184Gln Uncertain significance Single submitter
- CDK11A p.Lys20Arg Uncertain significance Single submitter
- CDK11A p.Lys496Arg Uncertain significance Single submitter
- CDK11A p.Lys96Gln Uncertain significance Single submitter
- CDK11A p.Met154Ile Uncertain significance Single submitter
- CDK11A p.Met179Thr Uncertain significance Single submitter
- CDK11A p.Met685Thr Uncertain significance Single submitter
- CDK11A p.Met73Val Uncertain significance Single submitter
- CDK11A p.Met91Val Uncertain significance Single submitter
- CDK11A p.Pro412Leu Uncertain significance Single submitter
- CDK11A p.Pro464Leu Uncertain significance Single submitter
- CDK11A p.Pro591Ala Uncertain significance Single submitter
- CDK11A p.Ser360Leu Uncertain significance Single submitter
- CDK11A p.Ser383Asn Uncertain significance Single submitter
- CDK11A p.Ser384Asn Uncertain significance Single submitter
- CDK11A p.Ser574Tyr Uncertain significance Single submitter
- CDK11A p.Ser627Trp Uncertain significance Single submitter
- CDK11A p.Ser662Arg Uncertain significance Single submitter
- CDK11A p.Thr380Arg Uncertain significance Single submitter
- CDK11A p.Thr466Arg Uncertain significance Single submitter
- CDK11A p.Thr466Met Uncertain significance Single submitter
- CDK11A p.Thr580Ala Uncertain significance Single submitter
- CDK11A p.Thr580Ser Uncertain significance Single submitter
- CDK11A p.Trp587Gly Uncertain significance Single submitter
- CDK11A p.Tyr67Cys Uncertain significance Single submitter
- CDK11A p.Val392Met Uncertain significance Single submitter
- CDK11A p.Val485Phe Uncertain significance Single submitter
Predictors split 39
The independent predictors disagree with each other — read with care.
- CDK11A p.Ala597Val Uncertain significance Single submitter
- CDK11A p.Arg131Cys Uncertain significance Single submitter
- CDK11A p.Arg175Pro Uncertain significance Single submitter
- CDK11A p.Arg194Trp Uncertain significance Single submitter
- CDK11A p.Arg195Trp Uncertain significance Single submitter
- CDK11A p.Arg22Gln Uncertain significance Single submitter
- CDK11A p.Arg418Trp Uncertain significance Single submitter
- CDK11A p.Arg453Gln Uncertain significance Single submitter
- CDK11A p.Arg45Trp Uncertain significance Single submitter
- CDK11A p.Arg670Cys Uncertain significance Single submitter
- CDK11A p.Arg672Cys Uncertain significance Single submitter
- CDK11A p.Arg672His Uncertain significance Single submitter
- CDK11A p.Asp540Asn Uncertain significance Single submitter
- CDK11A p.Gln478Arg Uncertain significance Single submitter
- CDK11A p.Glu430Lys Uncertain significance Single submitter
- CDK11A p.Glu461Lys Uncertain significance Single submitter
- CDK11A p.Glu599Gly Uncertain significance Single submitter
- CDK11A p.Gly51Glu Uncertain significance Single submitter
- CDK11A p.Gly573Arg Uncertain significance Single submitter
- CDK11A p.His537Tyr Uncertain significance Single submitter
- CDK11A p.Ile474Thr Uncertain significance Single submitter
- CDK11A p.Leu13Phe Uncertain significance Single submitter
- CDK11A p.Lys20Met Uncertain significance Single submitter
- CDK11A p.Lys509Arg Uncertain significance Single submitter
- CDK11A p.Lys86Gln Uncertain significance Single submitter
- CDK11A p.Met456Thr Uncertain significance Single submitter
- CDK11A p.Met512Ile Uncertain significance Single submitter
- CDK11A p.Met606Ile Uncertain significance Single submitter
- CDK11A p.Phe682Leu Uncertain significance Single submitter
- CDK11A p.Pro581Leu Uncertain significance Single submitter
- CDK11A p.Pro654Leu Uncertain significance Single submitter
- CDK11A p.Pro654Ser Uncertain significance Single submitter
- CDK11A p.Pro87Leu Uncertain significance Single submitter
- CDK11A p.Pro87Ser Uncertain significance Single submitter
- CDK11A p.Ser338Asn Uncertain significance Single submitter
- CDK11A p.Ser47Tyr Uncertain significance Single submitter
- CDK11A p.Val420Ile Uncertain significance Single submitter
- CDK11A p.Val485Ile Uncertain significance Single submitter
- CDK11A p.Val604Met Uncertain significance Single submitter
All CDK11A variants
Likely benign 9
- p.Ala196= Single submitter
- p.Asn626Lys Single submitter
- p.Asp565= Single submitter
- p.Asp683= Single submitter
- p.Asp683Asn Single submitter
- p.Gln586Leu Single submitter
- p.Gly119= Single submitter
- p.His557= Single submitter
- p.Phe566= Single submitter
Uncertain significance 121
- p.Arg247Gln Multiple submitters ⚠
- p.Ala196Val Single submitter ⚠
- p.Ala558Thr Single submitter ⚠
- p.Ala590Thr Single submitter
- p.Ala597Val Single submitter ⚠
- p.Arg131Cys Single submitter ⚠
- p.Arg132Gln Single submitter ⚠
- p.Arg132Trp Single submitter ⚠
- p.Arg134Gln Single submitter ⚠
- p.Arg161Lys Single submitter ⚠
- p.Arg175Pro Single submitter ⚠
- p.Arg180Gln Single submitter ⚠
- p.Arg194Trp Single submitter ⚠
- p.Arg195Trp Single submitter ⚠
- p.Arg22Gln Single submitter ⚠
- p.Arg348Gln Single submitter ⚠
- p.Arg364Gln Single submitter ⚠
- p.Arg418Trp Single submitter ⚠
- p.Arg41Gln Single submitter ⚠
- p.Arg41Trp Single submitter ⚠
- p.Arg439Lys Single submitter ⚠
- p.Arg453Gln Single submitter ⚠
- p.Arg45Gln Single submitter ⚠
- p.Arg45Trp Single submitter ⚠
- p.Arg546His Single submitter ⚠
- p.Arg570Gln Single submitter ⚠
- p.Arg570Trp Single submitter ⚠
- p.Arg589Cys Single submitter
- p.Arg589His Single submitter ⚠
- p.Arg670Cys Single submitter ⚠
- p.Arg672Cys Single submitter ⚠
- p.Arg672His Single submitter ⚠
- p.Asn350Ile Single submitter ⚠
- p.Asp140Gly Single submitter ⚠
- p.Asp345Asn Single submitter ⚠
- p.Asp363Asn Single submitter ⚠
- p.Asp394Glu Single submitter ⚠
- p.Asp540Asn Single submitter ⚠
- p.Cys57Ser Single submitter ⚠
- p.Gln182His Single submitter ⚠
- p.Gln478Arg Single submitter ⚠
- p.Glu130Lys Single submitter ⚠
- p.Glu336Val Single submitter ⚠
- p.Glu368Lys Single submitter ⚠
- p.Glu402Gln Single submitter ⚠
- p.Glu402Gly Single submitter ⚠
- p.Glu402Lys Single submitter ⚠
- p.Glu430Lys Single submitter ⚠
- p.Glu461Asp Single submitter ⚠
- p.Glu461Lys Single submitter ⚠
- p.Glu50Asp Single submitter ⚠
- p.Glu599Gly Single submitter ⚠
- p.Gly118Ala Single submitter
- p.Gly491Ser Single submitter ⚠
- p.Gly51Glu Single submitter ⚠
- p.Gly567Glu Single submitter ⚠
- p.Gly573Arg Single submitter ⚠
- p.Gly596Ala Single submitter
- p.Gly610Ala Single submitter ⚠
- p.Gly614Glu Single submitter ⚠
- p.Gly674Ala Single submitter ⚠
- p.His506Gln Single submitter ⚠
- p.His537Tyr Single submitter ⚠
- p.Ile474Thr Single submitter ⚠
- p.Ile488Thr Single submitter ⚠
- p.Ile497Asn Single submitter ⚠
- p.Ile543Asn Single submitter ⚠
- p.Leu13Phe Single submitter ⚠
- p.Leu527Val Single submitter
- p.Lys101Arg Single submitter ⚠
- p.Lys120Thr Single submitter ⚠
- p.Lys184Gln Single submitter ⚠
- p.Lys20Arg Single submitter ⚠
- p.Lys20Met Single submitter ⚠
- p.Lys444fs Single submitter
- p.Lys496Arg Single submitter ⚠
- p.Lys509Arg Single submitter ⚠
- p.Lys86Gln Single submitter ⚠
- p.Lys96Gln Single submitter ⚠
- p.Met154Ile Single submitter ⚠
- p.Met179Thr Single submitter ⚠
- p.Met456Thr Single submitter ⚠
- p.Met512Ile Single submitter ⚠
- p.Met606Ile Single submitter ⚠
- p.Met685Thr Single submitter ⚠
- p.Met73Val Single submitter ⚠
- p.Met91Val Single submitter ⚠
- p.Phe682Leu Single submitter ⚠
- p.Pro412Leu Single submitter ⚠
- p.Pro464Leu Single submitter ⚠
- p.Pro581Leu Single submitter ⚠
- p.Pro591Ala Single submitter ⚠
- p.Pro654Leu Single submitter ⚠
- p.Pro654Ser Single submitter ⚠
- p.Pro66Arg Single submitter
- p.Pro66Leu Single submitter
- p.Pro87Leu Single submitter ⚠
- p.Pro87Ser Single submitter ⚠
- p.Ser338Asn Single submitter ⚠
- p.Ser360Leu Single submitter ⚠
- p.Ser383Asn Single submitter ⚠
- p.Ser384Asn Single submitter ⚠
- p.Ser47Tyr Single submitter ⚠
- p.Ser574Tyr Single submitter ⚠
- p.Ser627Trp Single submitter ⚠
- p.Ser662Arg Single submitter ⚠
- p.Thr380Arg Single submitter ⚠
- p.Thr466Arg Single submitter ⚠
- p.Thr466Met Single submitter ⚠
- p.Thr550Met Single submitter
- p.Thr580Ala Single submitter ⚠
- p.Thr580Ser Single submitter ⚠
- p.Thr618Ile Single submitter
- p.Trp587Gly Single submitter ⚠
- p.Tyr67Cys Single submitter ⚠
- p.Val392Met Single submitter ⚠
- p.Val420Ile Single submitter ⚠
- p.Val485Ile Single submitter ⚠
- p.Val485Phe Single submitter ⚠
- p.Val524Met Single submitter
- p.Val604Met Single submitter ⚠