Sugi Variant

Sugi Variant/CDK12

CDK12 — 1651 ClinVar variants

All ClinVar germline CDK12 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 1045 flagged for review →

1 Likely pathogenic · 1 Conflicting · 19 Benign · 5 Benign/Likely benign · 584 Likely benign · 1041 Uncertain significance

Full CDK12 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 1045

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors agree, ClinVar conflicts 1

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 658

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification. · showing the 150 best-reviewed of 658

Predictors split 386

The independent predictors disagree with each other — read with care. · showing the 150 best-reviewed of 386

All CDK12 variants

Likely pathogenic 1

  • p.Gly879Val No assertion criteria lung adenocarcinoma

Conflicting classifications of pathogenicity 1

Benign 19

Benign/Likely benign 5

  • c.2108+56T>A Multiple submitters hereditary breast ovarian cancer syndrome
  • p.Ile1131Val Multiple submitters hereditary breast ovarian cancer syndrome
  • p.Pro1275Leu Multiple submitters hereditary breast ovarian cancer syndrome ⚠
  • p.Ser434= Multiple submitters hereditary breast ovarian cancer syndrome
  • p.Thr1195Met Multiple submitters hereditary breast ovarian cancer syndrome ⚠

Likely benign 584

Showing the top 300 by review status; the full set is in the sitemap.

Uncertain significance 1041

Showing the top 300 by review status; the full set is in the sitemap.