CDK14 — 52 ClinVar variants
All ClinVar germline CDK14 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 47 flagged for review →
2 Benign · 50 Uncertain significance
Full CDK14 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 47
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 29
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CDK14 p.Ala382Val Uncertain significance Single submitter
- CDK14 p.Arg250His Uncertain significance Single submitter
- CDK14 p.Arg370Cys Uncertain significance Single submitter
- CDK14 p.Arg370Ser Uncertain significance Single submitter
- CDK14 p.Arg452Gln Uncertain significance Single submitter
- CDK14 p.Arg92Trp Uncertain significance Single submitter
- CDK14 p.Asn102Asp Uncertain significance Single submitter
- CDK14 p.Asn457Lys Uncertain significance Single submitter
- CDK14 p.Asn458Thr Uncertain significance Single submitter
- CDK14 p.Asp340His Uncertain significance Single submitter
- CDK14 p.Gln381Glu Uncertain significance Single submitter
- CDK14 p.Glu84Gly Uncertain significance Single submitter
- CDK14 p.Ile101Val Uncertain significance Single submitter
- CDK14 p.Ile321Thr Uncertain significance Single submitter
- CDK14 p.Lys69Thr Uncertain significance Single submitter
- CDK14 p.Met47Thr Uncertain significance Single submitter
- CDK14 p.Met55Val Uncertain significance Single submitter
- CDK14 p.Phe129Cys Uncertain significance Single submitter
- CDK14 p.Phe275Leu Uncertain significance Single submitter
- CDK14 p.Ser120Asn Uncertain significance Single submitter
- CDK14 p.Ser375Gly Uncertain significance Single submitter
- CDK14 p.Ser465Pro Uncertain significance Single submitter
- CDK14 p.Ser467Asn Uncertain significance Single submitter
- CDK14 p.Thr148Ile Uncertain significance Single submitter
- CDK14 p.Thr79Ala Uncertain significance Single submitter
- CDK14 p.Trp427Arg Uncertain significance Single submitter
- CDK14 p.Tyr220Cys Uncertain significance Single submitter
- CDK14 p.Tyr388Cys Uncertain significance Single submitter
- CDK14 p.Val156Ile Uncertain significance Single submitter
Predictors split 18
The independent predictors disagree with each other — read with care.
- CDK14 p.Arg117Trp Uncertain significance Single submitter
- CDK14 p.Arg425Trp Uncertain significance Single submitter
- CDK14 p.Arg452Trp Uncertain significance Single submitter
- CDK14 p.Asp394Glu Uncertain significance Single submitter
- CDK14 p.Glu417Lys Uncertain significance Single submitter
- CDK14 p.Ile193Val Uncertain significance Single submitter
- CDK14 p.Ile326Ser Uncertain significance Single submitter
- CDK14 p.Ile338Phe Uncertain significance Single submitter
- CDK14 p.Met315Val Uncertain significance Single submitter
- CDK14 p.Met335Ile Uncertain significance Single submitter
- CDK14 p.Met335Thr Uncertain significance Single submitter
- CDK14 p.Pro230Ala Uncertain significance Single submitter
- CDK14 p.Ser145Thr Uncertain significance Single submitter
- CDK14 p.Ser265Cys Uncertain significance Single submitter
- CDK14 p.Ser409Leu Uncertain significance Single submitter
- CDK14 p.Thr205Met Uncertain significance Single submitter
- CDK14 p.Thr267Met Uncertain significance Single submitter
- CDK14 p.Val58Met Uncertain significance Single submitter
All CDK14 variants
Uncertain significance 50
- c.124-16986G>A Single submitter
- c.124-17003A>G Single submitter
- c.124-17015A>T Single submitter
- p.Ala382Val Single submitter ⚠
- p.Arg117Trp Single submitter ⚠
- p.Arg250His Single submitter ⚠
- p.Arg370Cys Single submitter ⚠
- p.Arg370Ser Single submitter ⚠
- p.Arg425Trp Single submitter ⚠
- p.Arg452Gln Single submitter ⚠
- p.Arg452Trp Single submitter ⚠
- p.Arg92Trp Single submitter ⚠
- p.Asn102Asp Single submitter ⚠
- p.Asn457Lys Single submitter ⚠
- p.Asn458Thr Single submitter ⚠
- p.Asp340His Single submitter ⚠
- p.Asp394Glu Single submitter ⚠
- p.Gln381Glu Single submitter ⚠
- p.Glu417Lys Single submitter ⚠
- p.Glu84Gly Single submitter ⚠
- p.Ile101Val Single submitter ⚠
- p.Ile193Val Single submitter ⚠
- p.Ile321Thr Single submitter ⚠
- p.Ile326Ser Single submitter ⚠
- p.Ile338Phe Single submitter ⚠
- p.Lys69Thr Single submitter ⚠
- p.Met315Val Single submitter ⚠
- p.Met335Ile Single submitter ⚠
- p.Met335Thr Single submitter ⚠
- p.Met47Thr Single submitter ⚠
- p.Met55Val Single submitter ⚠
- p.Phe129Cys Single submitter ⚠
- p.Phe275Leu Single submitter ⚠
- p.Pro230Ala Single submitter ⚠
- p.Ser120Asn Single submitter ⚠
- p.Ser145Thr Single submitter ⚠
- p.Ser265Cys Single submitter ⚠
- p.Ser375Gly Single submitter ⚠
- p.Ser409Leu Single submitter ⚠
- p.Ser465Pro Single submitter ⚠
- p.Ser467Asn Single submitter ⚠
- p.Thr148Ile Single submitter ⚠
- p.Thr205Met Single submitter ⚠
- p.Thr267Met Single submitter ⚠
- p.Thr79Ala Single submitter ⚠
- p.Trp427Arg Single submitter ⚠
- p.Tyr220Cys Single submitter ⚠
- p.Tyr388Cys Single submitter ⚠
- p.Val156Ile Single submitter ⚠
- p.Val58Met Single submitter ⚠