CDK15 — 56 ClinVar variants
All ClinVar germline CDK15 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 56 flagged for review →
56 Uncertain significance
Full CDK15 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 56
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 39
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CDK15 p.Ala115Val Uncertain significance Single submitter
- CDK15 p.Ala63Ser Uncertain significance Single submitter
- CDK15 p.Arg148Gln Uncertain significance Single submitter
- CDK15 p.Arg247Gln Uncertain significance Single submitter
- CDK15 p.Arg266Trp Uncertain significance Single submitter
- CDK15 p.Asn200Thr Uncertain significance Single submitter
- CDK15 p.Asn305Ser Uncertain significance Single submitter
- CDK15 p.Asn352Lys Uncertain significance Single submitter
- CDK15 p.Asp84Asn Uncertain significance Single submitter
- CDK15 p.Cys79Gly Uncertain significance Single submitter
- CDK15 p.Glu280Lys Uncertain significance Single submitter
- CDK15 p.Gly110Asp Uncertain significance Single submitter
- CDK15 p.Gly112Ala Uncertain significance Single submitter
- CDK15 p.Gly273Glu Uncertain significance Single submitter
- CDK15 p.Gly285Asp Uncertain significance Single submitter
- CDK15 p.Gly355Arg Uncertain significance Single submitter
- CDK15 p.Gly425Val Uncertain significance Single submitter
- CDK15 p.Gly59Val Uncertain significance Single submitter
- CDK15 p.His165Arg Uncertain significance Single submitter
- CDK15 p.Ile283Val Uncertain significance Single submitter
- CDK15 p.Ile289Thr Uncertain significance Single submitter
- CDK15 p.Ile306Asn Uncertain significance Single submitter
- CDK15 p.Leu164Pro Uncertain significance Single submitter
- CDK15 p.Leu363Arg Uncertain significance Single submitter
- CDK15 p.Leu418Ile Uncertain significance Single submitter
- CDK15 p.Lys157Arg Uncertain significance Single submitter
- CDK15 p.Lys171Arg Uncertain significance Single submitter
- CDK15 p.Met367Thr Uncertain significance Single submitter
- CDK15 p.Phe300Ser Uncertain significance Single submitter
- CDK15 p.Pro342Leu Uncertain significance Single submitter
- CDK15 p.Pro96Ala Uncertain significance Single submitter
- CDK15 p.Ser253Thr Uncertain significance Single submitter
- CDK15 p.Ser365Cys Uncertain significance Single submitter
- CDK15 p.Thr53Ser Uncertain significance Single submitter
- CDK15 p.Trp325Cys Uncertain significance Single submitter
- CDK15 p.Val220Ile Uncertain significance Single submitter
- CDK15 p.Val261Met Uncertain significance Single submitter
- CDK15 p.Val376Ile Uncertain significance Single submitter
- CDK15 p.Val376Leu Uncertain significance Single submitter
Predictors split 17
The independent predictors disagree with each other — read with care.
- CDK15 p.Ala378Thr Uncertain significance Single submitter
- CDK15 p.Arg74Gln Uncertain significance Single submitter
- CDK15 p.Asn105Tyr Uncertain significance Single submitter
- CDK15 p.Glu276Gly Uncertain significance Single submitter
- CDK15 p.Glu322Gly Uncertain significance Single submitter
- CDK15 p.Leu390Val Uncertain significance Single submitter
- CDK15 p.Pro198Ser Uncertain significance Single submitter
- CDK15 p.Ser151Thr Uncertain significance Single submitter
- CDK15 p.Ser233Asn Uncertain significance Single submitter
- CDK15 p.Ser233Gly Uncertain significance Single submitter
- CDK15 p.Thr173Lys Uncertain significance Single submitter
- CDK15 p.Thr275Ile Uncertain significance Single submitter
- CDK15 p.Tyr214Cys Uncertain significance Single submitter
- CDK15 p.Tyr334His Uncertain significance Single submitter
- CDK15 p.Val142Ile Uncertain significance Single submitter
- CDK15 p.Val142Leu Uncertain significance Single submitter
- CDK15 p.Val177Ile Uncertain significance Single submitter
All CDK15 variants
Uncertain significance 56
- p.Ala115Val Single submitter ⚠
- p.Ala378Thr Single submitter ⚠
- p.Ala63Ser Single submitter ⚠
- p.Arg148Gln Single submitter ⚠
- p.Arg247Gln Single submitter ⚠
- p.Arg266Trp Single submitter ⚠
- p.Arg74Gln Single submitter ⚠
- p.Asn105Tyr Single submitter ⚠
- p.Asn200Thr Single submitter ⚠
- p.Asn305Ser Single submitter ⚠
- p.Asn352Lys Single submitter ⚠
- p.Asp84Asn Single submitter ⚠
- p.Cys79Gly Single submitter ⚠
- p.Glu276Gly Single submitter ⚠
- p.Glu280Lys Single submitter ⚠
- p.Glu322Gly Single submitter ⚠
- p.Gly110Asp Single submitter ⚠
- p.Gly112Ala Single submitter ⚠
- p.Gly273Glu Single submitter ⚠
- p.Gly285Asp Single submitter ⚠
- p.Gly355Arg Single submitter ⚠
- p.Gly425Val Single submitter ⚠
- p.Gly59Val Single submitter ⚠
- p.His165Arg Single submitter ⚠
- p.Ile283Val Single submitter ⚠
- p.Ile289Thr Single submitter ⚠
- p.Ile306Asn Single submitter ⚠
- p.Leu164Pro Single submitter ⚠
- p.Leu363Arg Single submitter ⚠
- p.Leu390Val Single submitter ⚠
- p.Leu418Ile Single submitter ⚠
- p.Lys157Arg Single submitter ⚠
- p.Lys171Arg Single submitter ⚠
- p.Met367Thr Single submitter ⚠
- p.Phe300Ser Single submitter ⚠
- p.Pro198Ser Single submitter ⚠
- p.Pro342Leu Single submitter ⚠
- p.Pro96Ala Single submitter ⚠
- p.Ser151Thr Single submitter ⚠
- p.Ser233Asn Single submitter ⚠
- p.Ser233Gly Single submitter ⚠
- p.Ser253Thr Single submitter ⚠
- p.Ser365Cys Single submitter ⚠
- p.Thr173Lys Single submitter ⚠
- p.Thr275Ile Single submitter ⚠
- p.Thr53Ser Single submitter ⚠
- p.Trp325Cys Single submitter ⚠
- p.Tyr214Cys Single submitter ⚠
- p.Tyr334His Single submitter ⚠
- p.Val142Ile Single submitter ⚠
- p.Val142Leu Single submitter ⚠
- p.Val177Ile Single submitter ⚠
- p.Val220Ile Single submitter ⚠
- p.Val261Met Single submitter ⚠
- p.Val376Ile Single submitter ⚠
- p.Val376Leu Single submitter ⚠