CDK17 — 48 ClinVar variants
All ClinVar germline CDK17 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 47 flagged for review →
1 Benign · 47 Uncertain significance
Full CDK17 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 47
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 24
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CDK17 p.Ala86Val Uncertain significance Single submitter
- CDK17 p.Arg135Gln Uncertain significance Single submitter
- CDK17 p.Arg135Trp Uncertain significance Single submitter
- CDK17 p.Arg474Gln Uncertain significance Single submitter
- CDK17 p.Asn249Thr Uncertain significance Single submitter
- CDK17 p.Asn426Ser Uncertain significance Single submitter
- CDK17 p.Asp155Val Uncertain significance Single submitter
- CDK17 p.Glu365Lys Uncertain significance Single submitter
- CDK17 p.Gly374Asp Uncertain significance Single submitter
- CDK17 p.Ile163Met Uncertain significance Single submitter
- CDK17 p.Ile450Met Uncertain significance Single submitter
- CDK17 p.Leu10Phe Uncertain significance Single submitter
- CDK17 p.Met138Val Uncertain significance Single submitter
- CDK17 p.Pro440Ala Uncertain significance Single submitter
- CDK17 p.Pro68Ser Uncertain significance Single submitter
- CDK17 p.Pro69Ala Uncertain significance Single submitter
- CDK17 p.Pro73Ser Uncertain significance Single submitter
- CDK17 p.Ser364Leu Uncertain significance Single submitter
- CDK17 p.Thr205Ala Uncertain significance Single submitter
- CDK17 p.Thr264Ile Uncertain significance Single submitter
- CDK17 p.Thr393Ile Uncertain significance Single submitter
- CDK17 p.Thr50Ala Uncertain significance Single submitter
- CDK17 p.Tyr277Cys Uncertain significance Single submitter
- CDK17 p.Val218Leu Uncertain significance Single submitter
Predictors split 23
The independent predictors disagree with each other — read with care.
- CDK17 p.Ala439Thr Uncertain significance Single submitter
- CDK17 p.Arg504Gln Uncertain significance Single submitter
- CDK17 p.Arg7Thr Uncertain significance Single submitter
- CDK17 p.Asn347Ser Uncertain significance Single submitter
- CDK17 p.Asn426His Uncertain significance Single submitter
- CDK17 p.Gln455Lys Uncertain significance Single submitter
- CDK17 p.Glu24Lys Uncertain significance Single submitter
- CDK17 p.Gly502Ala Uncertain significance Single submitter
- CDK17 p.His288Asn Uncertain significance Single submitter
- CDK17 p.Ile151Leu Uncertain significance Single submitter
- CDK17 p.Ile489Val Uncertain significance Single submitter
- CDK17 p.Leu22Ser Uncertain significance Single submitter
- CDK17 p.Lys188Arg Uncertain significance Single submitter
- CDK17 p.Lys459Met Uncertain significance Single submitter
- CDK17 p.Pro166Ala Uncertain significance Single submitter
- CDK17 p.Pro414Thr Uncertain significance Single submitter
- CDK17 p.Pro428Ala Uncertain significance Single submitter
- CDK17 p.Pro501Leu Uncertain significance Single submitter
- CDK17 p.Ser165Arg Uncertain significance Single submitter
- CDK17 p.Ser23Cys Uncertain significance Single submitter
- CDK17 p.Ser507Cys Uncertain significance Single submitter
- CDK17 p.Thr30Ile Uncertain significance Single submitter
- CDK17 p.Val290Ile Uncertain significance Single submitter
All CDK17 variants
Benign 1
- c.716-4G>A Single submitter
Uncertain significance 47
- p.Ala439Thr Single submitter ⚠
- p.Ala86Val Single submitter ⚠
- p.Arg135Gln Single submitter ⚠
- p.Arg135Trp Single submitter ⚠
- p.Arg474Gln Single submitter ⚠
- p.Arg504Gln Single submitter ⚠
- p.Arg7Thr Single submitter ⚠
- p.Asn249Thr Single submitter ⚠
- p.Asn347Ser Single submitter ⚠
- p.Asn426His Single submitter ⚠
- p.Asn426Ser Single submitter ⚠
- p.Asp155Val Single submitter ⚠
- p.Gln455Lys Single submitter ⚠
- p.Glu24Lys Single submitter ⚠
- p.Glu365Lys Single submitter ⚠
- p.Gly374Asp Single submitter ⚠
- p.Gly502Ala Single submitter ⚠
- p.His288Asn Single submitter ⚠
- p.Ile151Leu Single submitter ⚠
- p.Ile163Met Single submitter ⚠
- p.Ile450Met Single submitter ⚠
- p.Ile489Val Single submitter ⚠
- p.Leu10Phe Single submitter ⚠
- p.Leu22Ser Single submitter ⚠
- p.Lys188Arg Single submitter ⚠
- p.Lys459Met Single submitter ⚠
- p.Met138Val Single submitter ⚠
- p.Pro166Ala Single submitter ⚠
- p.Pro414Thr Single submitter ⚠
- p.Pro428Ala Single submitter ⚠
- p.Pro440Ala Single submitter ⚠
- p.Pro501Leu Single submitter ⚠
- p.Pro68Ser Single submitter ⚠
- p.Pro69Ala Single submitter ⚠
- p.Pro73Ser Single submitter ⚠
- p.Ser165Arg Single submitter ⚠
- p.Ser23Cys Single submitter ⚠
- p.Ser364Leu Single submitter ⚠
- p.Ser507Cys Single submitter ⚠
- p.Thr205Ala Single submitter ⚠
- p.Thr264Ile Single submitter ⚠
- p.Thr30Ile Single submitter ⚠
- p.Thr393Ile Single submitter ⚠
- p.Thr50Ala Single submitter ⚠
- p.Tyr277Cys Single submitter ⚠
- p.Val218Leu Single submitter ⚠
- p.Val290Ile Single submitter ⚠