CDK18 — 77 ClinVar variants
All ClinVar germline CDK18 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 68 flagged for review →
2 Likely benign · 75 Uncertain significance
Full CDK18 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 68
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 43
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CDK18 p.Ala335Val Uncertain significance Single submitter
- CDK18 p.Arg126Cys Uncertain significance Single submitter
- CDK18 p.Arg126Leu Uncertain significance Single submitter
- CDK18 p.Arg176Trp Uncertain significance Single submitter
- CDK18 p.Arg19Gly Uncertain significance Single submitter
- CDK18 p.Arg251Trp Uncertain significance Single submitter
- CDK18 p.Arg264Gln Uncertain significance Single submitter
- CDK18 p.Arg264Pro Uncertain significance Single submitter
- CDK18 p.Arg264Trp Uncertain significance Single submitter
- CDK18 p.Arg413His Uncertain significance Single submitter
- CDK18 p.Arg41Gln Uncertain significance Single submitter
- CDK18 p.Arg426Gln Uncertain significance Single submitter
- CDK18 p.Arg465Gln Uncertain significance Single submitter
- CDK18 p.Arg82Gln Uncertain significance Single submitter
- CDK18 p.Asn39Lys Uncertain significance Single submitter
- CDK18 p.Asp231Glu Uncertain significance Single submitter
- CDK18 p.Cys185Tyr Uncertain significance Single submitter
- CDK18 p.Gln72His Uncertain significance Single submitter
- CDK18 p.Glu180Lys Uncertain significance Single submitter
- CDK18 p.Glu190Asp Uncertain significance Single submitter
- CDK18 p.Glu190Gln Uncertain significance Single submitter
- CDK18 p.Glu430Lys Uncertain significance Single submitter
- CDK18 p.Glu43Lys Uncertain significance Single submitter
- CDK18 p.Gly139Arg Uncertain significance Single submitter
- CDK18 p.Gly161Glu Uncertain significance Single submitter
- CDK18 p.Gly337Glu Uncertain significance Single submitter
- CDK18 p.His257Gln Uncertain significance Single submitter
- CDK18 p.Ile136Thr Uncertain significance Single submitter
- CDK18 p.Ile209Thr Uncertain significance Single submitter
- CDK18 p.Ile23Thr Uncertain significance Single submitter
- CDK18 p.Ile2Val Uncertain significance Single submitter
- CDK18 p.Met90Thr Uncertain significance Single submitter
- CDK18 p.Pro70Leu Uncertain significance Single submitter
- CDK18 p.Ser117Gly Uncertain significance Single submitter
- CDK18 p.Ser125Thr Uncertain significance Single submitter
- CDK18 p.Ser291Thr Uncertain significance Single submitter
- CDK18 p.Ser412Thr Uncertain significance Single submitter
- CDK18 p.Thr336Arg Uncertain significance Single submitter
- CDK18 p.Thr64Ala Uncertain significance Single submitter
- CDK18 p.Tyr144Phe Uncertain significance Single submitter
- CDK18 p.Tyr155His Uncertain significance Single submitter
- CDK18 p.Val203Leu Uncertain significance Single submitter
- CDK18 p.Val432Gly Uncertain significance Single submitter
Predictors split 25
The independent predictors disagree with each other — read with care.
- CDK18 p.Ala254Thr Uncertain significance Single submitter
- CDK18 p.Arg104Cys Uncertain significance Single submitter
- CDK18 p.Arg12His Uncertain significance Single submitter
- CDK18 p.Arg162Cys Uncertain significance Single submitter
- CDK18 p.Arg19Cys Uncertain significance Single submitter
- CDK18 p.Arg213Trp Uncertain significance Single submitter
- CDK18 p.Arg276Ser Uncertain significance Single submitter
- CDK18 p.Arg41Trp Uncertain significance Single submitter
- CDK18 p.Arg431Cys Uncertain significance Single submitter
- CDK18 p.Arg431His Uncertain significance Single submitter
- CDK18 p.Arg81Trp Uncertain significance Single submitter
- CDK18 p.Arg87Cys Uncertain significance Single submitter
- CDK18 p.Asn274Ser Uncertain significance Single submitter
- CDK18 p.Asn468Asp Uncertain significance Single submitter
- CDK18 p.Gly367Ala Uncertain significance Single submitter
- CDK18 p.Gly367Asp Uncertain significance Single submitter
- CDK18 p.His433Tyr Uncertain significance Single submitter
- CDK18 p.Leu340Val Uncertain significance Single submitter
- CDK18 p.Lys146Asn Uncertain significance Single submitter
- CDK18 p.Lys411Thr Uncertain significance Single submitter
- CDK18 p.Pro366His Uncertain significance Single submitter
- CDK18 p.Pro384Arg Uncertain significance Single submitter
- CDK18 p.Pro453Gln Uncertain significance Single submitter
- CDK18 p.Val145Met Uncertain significance Single submitter
- CDK18 p.Val242Ile Uncertain significance Single submitter
All CDK18 variants
Likely benign 2
- p.Leu253= Single submitter
- p.Thr166Met Single submitter
Uncertain significance 75
- c.273+26G>A Multiple submitters
- c.273+41G>A Single submitter
- c.273+44C>T Single submitter
- c.273+47A>C Single submitter
- c.273+4A>T Single submitter
- c.273+62G>C Single submitter
- c.273+82C>A Single submitter
- p.Ala254Thr Single submitter ⚠
- p.Ala335Val Single submitter ⚠
- p.Arg104Cys Single submitter ⚠
- p.Arg126Cys Single submitter ⚠
- p.Arg126Leu Single submitter ⚠
- p.Arg12His Single submitter ⚠
- p.Arg162Cys Single submitter ⚠
- p.Arg176Trp Single submitter ⚠
- p.Arg19Cys Single submitter ⚠
- p.Arg19Gly Single submitter ⚠
- p.Arg213Trp Single submitter ⚠
- p.Arg251Trp Single submitter ⚠
- p.Arg264Gln Single submitter ⚠
- p.Arg264Pro Single submitter ⚠
- p.Arg264Trp Single submitter ⚠
- p.Arg276Ser Single submitter ⚠
- p.Arg413His Single submitter ⚠
- p.Arg41Gln Single submitter ⚠
- p.Arg41Trp Single submitter ⚠
- p.Arg426Gln Single submitter ⚠
- p.Arg431Cys Single submitter ⚠
- p.Arg431His Single submitter ⚠
- p.Arg465Gln Single submitter ⚠
- p.Arg81Trp Single submitter ⚠
- p.Arg82Gln Single submitter ⚠
- p.Arg87Cys Single submitter ⚠
- p.Asn274Ser Single submitter ⚠
- p.Asn39Lys Single submitter ⚠
- p.Asn468Asp Single submitter ⚠
- p.Asp231Glu Single submitter ⚠
- p.Cys185Tyr Single submitter ⚠
- p.Gln72His Single submitter ⚠
- p.Glu180Lys Single submitter ⚠
- p.Glu190Asp Single submitter ⚠
- p.Glu190Gln Single submitter ⚠
- p.Glu430Lys Single submitter ⚠
- p.Glu43Lys Single submitter ⚠
- p.Gly139Arg Single submitter ⚠
- p.Gly161Glu Single submitter ⚠
- p.Gly337Glu Single submitter ⚠
- p.Gly367Ala Single submitter ⚠
- p.Gly367Asp Single submitter ⚠
- p.His257Gln Single submitter ⚠
- p.His433Tyr Single submitter ⚠
- p.Ile136Thr Single submitter ⚠
- p.Ile209Thr Single submitter ⚠
- p.Ile23Thr Single submitter ⚠
- p.Ile2Val Single submitter ⚠
- p.Leu340Val Single submitter ⚠
- p.Lys146Asn Single submitter ⚠
- p.Lys411Thr Single submitter ⚠
- p.Met90Thr Single submitter ⚠
- p.Pro366His Single submitter ⚠
- p.Pro384Arg Single submitter ⚠
- p.Pro453Gln Single submitter ⚠
- p.Pro70Leu Single submitter ⚠
- p.Ser117Gly Single submitter ⚠
- p.Ser125Thr Single submitter ⚠
- p.Ser291Thr Single submitter ⚠
- p.Ser412Thr Single submitter ⚠
- p.Thr336Arg Single submitter ⚠
- p.Thr64Ala Single submitter ⚠
- p.Tyr144Phe Single submitter ⚠
- p.Tyr155His Single submitter ⚠
- p.Val145Met Single submitter ⚠
- p.Val203Leu Single submitter ⚠
- p.Val242Ile Single submitter ⚠
- p.Val432Gly Single submitter ⚠