CDK2 — 13 ClinVar variants
All ClinVar germline CDK2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 12 flagged for review →
1 Likely benign · 12 Uncertain significance
Full CDK2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 12
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 7
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CDK2 p.Arg200Gln Uncertain significance Single submitter
- CDK2 p.Arg200Trp Uncertain significance Single submitter
- CDK2 p.Cys191Arg Uncertain significance Single submitter
- CDK2 p.Glu57Ala Uncertain significance Single submitter
- CDK2 p.His268Leu Uncertain significance Single submitter
- CDK2 p.Lys105Glu Uncertain significance Single submitter
- CDK2 p.Val79Gly Uncertain significance Single submitter
Predictors split 5
The independent predictors disagree with each other — read with care.
All CDK2 variants
Likely benign 1
- p.Ile275= Single submitter
Uncertain significance 12
- p.Arg199His Single submitter ⚠
- p.Arg200Gln Single submitter ⚠
- p.Arg200Trp Single submitter ⚠
- p.Arg214Gln Single submitter ⚠
- p.Asp288His Single submitter ⚠
- p.Cys191Arg Single submitter ⚠
- p.Glu57Ala Single submitter ⚠
- p.His268Leu Single submitter ⚠
- p.Ile10Leu Single submitter ⚠
- p.Lys105Glu Single submitter ⚠
- p.Ser276Pro Single submitter ⚠
- p.Val79Gly Single submitter ⚠