CDK20 — 120 ClinVar variants
All ClinVar germline CDK20 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 82 flagged for review →
13 Benign · 18 Likely benign · 89 Uncertain significance
Full CDK20 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 82
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 48
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
-
CDK20 p.Phe204Leu
Uncertain significance
Multiple submitters
intellectual disability
- CDK20 p.Ala295Thr Uncertain significance Single submitter
- CDK20 p.Ala48Thr Uncertain significance Single submitter
- CDK20 p.Ala54Thr Uncertain significance Single submitter
- CDK20 p.Arg126Trp Uncertain significance Single submitter
- CDK20 p.Arg276Cys Uncertain significance Single submitter
- CDK20 p.Arg276His Uncertain significance Single submitter
- CDK20 p.Arg305Gly Uncertain significance Single submitter
- CDK20 p.Arg327Gln Uncertain significance Single submitter
- CDK20 p.Arg340Gln Uncertain significance Single submitter
- CDK20 p.Asp155Glu Uncertain significance Single submitter
- CDK20 p.Asp155Gly Uncertain significance Single submitter
- CDK20 p.Asp186Asn Uncertain significance Single submitter
- CDK20 p.Asp322Val Uncertain significance Single submitter
- CDK20 p.Asp60Asn Uncertain significance Single submitter
- CDK20 p.Glu196Gln Uncertain significance Single submitter
- CDK20 p.Glu252Asp Uncertain significance Single submitter
- CDK20 p.Glu25Ala Uncertain significance Single submitter
- CDK20 p.Glu25Gln Uncertain significance Single submitter
- CDK20 p.Glu331Ala Uncertain significance Single submitter
- CDK20 p.Gly11Arg Uncertain significance Single submitter
- CDK20 p.His15Gln Uncertain significance Single submitter
- CDK20 p.His319Asp Uncertain significance Single submitter
- CDK20 p.Ile17Phe Uncertain significance Single submitter
- CDK20 p.Ile193Thr Uncertain significance Single submitter
- CDK20 p.Ile302Thr Uncertain significance Single submitter
- CDK20 p.Leu254Arg Uncertain significance Single submitter
- CDK20 p.Leu37Val Uncertain significance Single submitter
- CDK20 p.Leu49Pro Uncertain significance Single submitter
- CDK20 p.Leu55Arg Uncertain significance Single submitter
- CDK20 p.Leu55Val Uncertain significance Single submitter
- CDK20 p.Lys142Asn Uncertain significance Single submitter
- CDK20 p.Lys207Arg Uncertain significance Single submitter
- CDK20 p.Lys281Glu Uncertain significance Single submitter
- CDK20 p.Lys34Glu Uncertain significance Single submitter
- CDK20 p.Lys34Met Uncertain significance Single submitter
- CDK20 p.Met248Thr Uncertain significance Single submitter
- CDK20 p.Pro318Arg Uncertain significance Single submitter
- CDK20 p.Pro328Arg Uncertain significance Single submitter
- CDK20 p.Pro341Ser Uncertain significance Single submitter
- CDK20 p.Ser136Asn Uncertain significance Single submitter
- CDK20 p.Ser332Leu Uncertain significance Single submitter
-
CDK20 p.Tyr215His
Uncertain significance
Single submitter
CDK20-related disorder
- CDK20 p.Val185Ile Uncertain significance Single submitter
- CDK20 p.Val190Glu Uncertain significance Single submitter
- CDK20 p.Val24Met Uncertain significance Single submitter
- CDK20 p.Val325Met Uncertain significance Single submitter
- CDK20 p.Val35Ala Uncertain significance Single submitter
Predictors split 34
The independent predictors disagree with each other — read with care.
- CDK20 p.Ala261Glu Uncertain significance Single submitter
- CDK20 p.Ala279Thr Uncertain significance Single submitter
- CDK20 p.Ala89Val Uncertain significance Single submitter
- CDK20 p.Arg218Cys Uncertain significance Single submitter
- CDK20 p.Arg305Cys Uncertain significance Single submitter
- CDK20 p.Arg327Trp Uncertain significance Single submitter
- CDK20 p.Arg39Gln Uncertain significance Single submitter
- CDK20 p.Arg39Pro Uncertain significance Single submitter
- CDK20 p.Arg93Cys Uncertain significance Single submitter
- CDK20 p.Asn122Asp Uncertain significance Single submitter
- CDK20 p.Asp155His Uncertain significance Single submitter
- CDK20 p.Asp209Asn Uncertain significance Single submitter
- CDK20 p.Asp42Asn Uncertain significance Single submitter
- CDK20 p.Gln3His Uncertain significance Single submitter
- CDK20 p.Glu252Val Uncertain significance Single submitter
- CDK20 p.Glu59Asp Uncertain significance Single submitter
- CDK20 p.Gly114Ala Uncertain significance Single submitter
- CDK20 p.Gly43Ser Uncertain significance Single submitter
- CDK20 p.Ile210Leu Uncertain significance Single submitter
- CDK20 p.Leu133Met Uncertain significance Single submitter
- CDK20 p.Leu159Ile Uncertain significance Single submitter
- CDK20 p.Lys239Arg Uncertain significance Single submitter
- CDK20 p.Met194Ile Uncertain significance Single submitter
- CDK20 p.Phe323Leu Uncertain significance Single submitter
- CDK20 p.Phe342Ser Uncertain significance Single submitter
- CDK20 p.Pro225Ser Uncertain significance Single submitter
- CDK20 p.Pro235Leu Uncertain significance Single submitter
- CDK20 p.Ser153Cys Uncertain significance Single submitter
- CDK20 p.Ser153Phe Uncertain significance Single submitter
- CDK20 p.Val216Met Uncertain significance Single submitter
- CDK20 p.Val253Met Uncertain significance Single submitter
- CDK20 p.Val257Ile Uncertain significance Single submitter
-
CDK20 p.Arg179Cys
Likely benign
No assertion criteria
CDK20-related disorder
-
CDK20 p.Val91Met
Uncertain significance
No assertion criteria
CDK20-related disorder
All CDK20 variants
Benign 13
- c.189+23G>C Multiple submitters
- c.378+19C>T Multiple submitters
- c.564-44C>T Multiple submitters
- c.688-214G>A Multiple submitters
- c.76-20G>T Multiple submitters
- c.76-66T>C Multiple submitters
- c.*153C>T Multiple submitters
- p.Glu41= Multiple submitters
- p.His73= Multiple submitters
- p.Pro205= Multiple submitters
- c.500+8G>A Single submitter
- p.Ser86= Single submitter
- p.Lys281Arg No assertion criteria CDK20-related disorder
Likely benign 18
- p.His324= Multiple submitters
- c.500+5_500+6del Single submitter
- p.Arg276= Single submitter
- p.Gln260= Single submitter
- p.Glu251= Single submitter
- p.Gly346= Single submitter
- p.Ile277= Single submitter
- p.Leu269= Single submitter
- p.Pro235= Single submitter
- c.190-6C>A No assertion criteria CDK20-related disorder
- c.76-52CT[2] No assertion criteria CDK20-related disorder
- c.-10C>T No assertion criteria CDK20-related disorder
- p.Ala95= No assertion criteria CDK20-related disorder
- p.Arg158Cys No assertion criteria CDK20-related disorder
- p.Arg179Cys No assertion criteria CDK20-related disorder ⚠
- p.Asp256= No assertion criteria CDK20-related disorder
- p.Glu345= No assertion criteria CDK20-related disorder
- p.Phe83= No assertion criteria CDK20-related disorder
Uncertain significance 89
- p.Phe204Leu Multiple submitters intellectual disability ⚠
- c.564delG Single submitter
- c.687+6T>C Single submitter
- p.Ala261Glu Single submitter ⚠
- p.Ala279Thr Single submitter ⚠
- p.Ala295Thr Single submitter ⚠
- p.Ala48Thr Single submitter ⚠
- p.Ala54Thr Single submitter ⚠
- p.Ala89Val Single submitter ⚠
- p.Arg126Trp Single submitter ⚠
- p.Arg218Cys Single submitter ⚠
- p.Arg276Cys Single submitter ⚠
- p.Arg276His Single submitter ⚠
- p.Arg305Cys Single submitter ⚠
- p.Arg305Gly Single submitter ⚠
- p.Arg327Gln Single submitter ⚠
- p.Arg327Trp Single submitter ⚠
- p.Arg340Gln Single submitter ⚠
- p.Arg39Gln Single submitter ⚠
- p.Arg39Pro Single submitter ⚠
- p.Arg93Cys Single submitter ⚠
- p.Asn122Asp Single submitter ⚠
- p.Asp155Glu Single submitter ⚠
- p.Asp155Gly Single submitter ⚠
- p.Asp155His Single submitter ⚠
- p.Asp186Asn Single submitter ⚠
- p.Asp209Asn Single submitter ⚠
- p.Asp236fs Single submitter hereditary breast ovarian cancer syndrome
- p.Asp322Val Single submitter ⚠
- p.Asp42Asn Single submitter ⚠
- p.Asp60Asn Single submitter ⚠
- p.Gln3His Single submitter ⚠
- p.Glu196Gln Single submitter ⚠
- p.Glu252Asp Single submitter ⚠
- p.Glu252Val Single submitter ⚠
- p.Glu25Ala Single submitter ⚠
- p.Glu25Gln Single submitter ⚠
- p.Glu331Ala Single submitter ⚠
- p.Glu59Asp Single submitter ⚠
- p.Glu82Ter Single submitter
- p.Gly114Ala Single submitter ⚠
- p.Gly11Arg Single submitter ⚠
- p.Gly43Ser Single submitter ⚠
- p.His15Gln Single submitter ⚠
- p.His319Asp Single submitter ⚠
- p.His319fs Single submitter
- p.Ile17Phe Single submitter ⚠
- p.Ile193Thr Single submitter ⚠
- p.Ile210Leu Single submitter ⚠
- p.Ile302Thr Single submitter ⚠
- p.Leu133Met Single submitter ⚠
- p.Leu159Ile Single submitter ⚠
- p.Leu254Arg Single submitter ⚠
- p.Leu37Val Single submitter ⚠
- p.Leu49Pro Single submitter ⚠
- p.Leu55Arg Single submitter ⚠
- p.Leu55Val Single submitter ⚠
- p.Lys142Asn Single submitter ⚠
- p.Lys207Arg Single submitter ⚠
- p.Lys239Arg Single submitter ⚠
- p.Lys281= Single submitter
- p.Lys281Glu Single submitter ⚠
- p.Lys34Glu Single submitter ⚠
- p.Lys34Met Single submitter ⚠
- p.Met194Ile Single submitter ⚠
- p.Met248Thr Single submitter ⚠
- p.Phe323Leu Single submitter ⚠
- p.Phe342Ser Single submitter ⚠
- p.Pro225Ser Single submitter ⚠
- p.Pro235Leu Single submitter ⚠
- p.Pro318Arg Single submitter ⚠
- p.Pro328Arg Single submitter ⚠
- p.Pro341Ser Single submitter ⚠
- p.Ser136Asn Single submitter ⚠
- p.Ser153Cys Single submitter ⚠
- p.Ser153Phe Single submitter ⚠
- p.Ser332Leu Single submitter ⚠
- p.Trp188Ter Single submitter hearing loss disorder
- p.Tyr215His Single submitter CDK20-related disorder ⚠
- p.Val185Ile Single submitter ⚠
- p.Val190Glu Single submitter ⚠
- p.Val216Met Single submitter ⚠
- p.Val24Met Single submitter ⚠
- p.Val253Met Single submitter ⚠
- p.Val257Ile Single submitter ⚠
- p.Val30fs Single submitter
- p.Val325Met Single submitter ⚠
- p.Val35Ala Single submitter ⚠
- p.Val91Met No assertion criteria CDK20-related disorder ⚠