CDK2AP2 — 15 ClinVar variants
All ClinVar germline CDK2AP2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 12 flagged for review →
1 Benign · 2 Likely benign · 12 Uncertain significance
Full CDK2AP2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 12
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 6
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CDK2AP2 p.Ala9Thr Uncertain significance Single submitter
- CDK2AP2 p.Glu83Gln Uncertain significance Single submitter
- CDK2AP2 p.Gly15Ser Uncertain significance Single submitter
- CDK2AP2 p.Met62Leu Uncertain significance Single submitter
- CDK2AP2 p.Ser97Arg Uncertain significance Single submitter
- CDK2AP2 p.Thr75Ala Uncertain significance Single submitter
Predictors split 6
The independent predictors disagree with each other — read with care.
- CDK2AP2 p.Met56Thr Uncertain significance Single submitter
- CDK2AP2 p.Pro19Leu Uncertain significance Single submitter
- CDK2AP2 p.Pro26Leu Uncertain significance Single submitter
- CDK2AP2 p.Thr18Ser Uncertain significance Single submitter
- CDK2AP2 p.Tyr58Cys Uncertain significance Single submitter
- CDK2AP2 p.Val59Glu Uncertain significance Single submitter
All CDK2AP2 variants
Benign 1
- p.Gln60= Multiple submitters
Uncertain significance 12
- p.Ala9Thr Single submitter ⚠
- p.Glu83Gln Single submitter ⚠
- p.Gly15Ser Single submitter ⚠
- p.Met56Thr Single submitter ⚠
- p.Met62Leu Single submitter ⚠
- p.Pro19Leu Single submitter ⚠
- p.Pro26Leu Single submitter ⚠
- p.Ser97Arg Single submitter ⚠
- p.Thr18Ser Single submitter ⚠
- p.Thr75Ala Single submitter ⚠
- p.Tyr58Cys Single submitter ⚠
- p.Val59Glu Single submitter ⚠