CDK3 — 35 ClinVar variants
All ClinVar germline CDK3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 35 flagged for review →
35 Uncertain significance
Full CDK3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 35
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 20
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CDK3 p.Ala282Asp Uncertain significance Single submitter
- CDK3 p.Arg126Gln Uncertain significance Single submitter
- CDK3 p.Arg150Cys Uncertain significance Single submitter
- CDK3 p.Arg150His Uncertain significance Single submitter
- CDK3 p.Arg302Gln Uncertain significance Single submitter
- CDK3 p.Arg74Gly Uncertain significance Single submitter
- CDK3 p.Asn136Ser Uncertain significance Single submitter
- CDK3 p.Gln131Lys Uncertain significance Single submitter
- CDK3 p.Glu290Asp Uncertain significance Single submitter
- CDK3 p.Glu73Asp Uncertain significance Single submitter
- CDK3 p.Glu98Ala Uncertain significance Single submitter
- CDK3 p.Gly153Val Uncertain significance Single submitter
- CDK3 p.Ile124Thr Uncertain significance Single submitter
- CDK3 p.Pro155Ser Uncertain significance Single submitter
- CDK3 p.Pro289Ala Uncertain significance Single submitter
- CDK3 p.Pro95Arg Uncertain significance Single submitter
- CDK3 p.Thr181Asn Uncertain significance Single submitter
- CDK3 p.Tyr298Asp Uncertain significance Single submitter
- CDK3 p.Val69Met Uncertain significance Single submitter
- CDK3 p.Val79Met Uncertain significance Single submitter
Predictors split 15
The independent predictors disagree with each other — read with care.
- CDK3 p.Ala170Ser Uncertain significance Single submitter
- CDK3 p.Arg199Gln Uncertain significance Single submitter
- CDK3 p.Arg214Cys Uncertain significance Single submitter
- CDK3 p.Arg217His Uncertain significance Single submitter
- CDK3 p.Arg296Cys Uncertain significance Single submitter
- CDK3 p.Gln265Glu Uncertain significance Single submitter
- CDK3 p.His121Arg Uncertain significance Single submitter
- CDK3 p.Leu108Val Uncertain significance Single submitter
- CDK3 p.Leu76Ile Uncertain significance Single submitter
- CDK3 p.Lys278Arg Uncertain significance Single submitter
- CDK3 p.Lys6Glu Uncertain significance Single submitter
- CDK3 p.Thr276Ala Uncertain significance Single submitter
- CDK3 p.Tyr107Cys Uncertain significance Single submitter
- CDK3 p.Tyr77Cys Uncertain significance Single submitter
- CDK3 p.Val154Met Uncertain significance Single submitter
All CDK3 variants
Uncertain significance 35
- p.Ala170Ser Single submitter ⚠
- p.Ala282Asp Single submitter ⚠
- p.Arg126Gln Single submitter ⚠
- p.Arg150Cys Single submitter ⚠
- p.Arg150His Single submitter ⚠
- p.Arg199Gln Single submitter ⚠
- p.Arg214Cys Single submitter ⚠
- p.Arg217His Single submitter ⚠
- p.Arg296Cys Single submitter ⚠
- p.Arg302Gln Single submitter ⚠
- p.Arg74Gly Single submitter ⚠
- p.Asn136Ser Single submitter ⚠
- p.Gln131Lys Single submitter ⚠
- p.Gln265Glu Single submitter ⚠
- p.Glu290Asp Single submitter ⚠
- p.Glu73Asp Single submitter ⚠
- p.Glu98Ala Single submitter ⚠
- p.Gly153Val Single submitter ⚠
- p.His121Arg Single submitter ⚠
- p.Ile124Thr Single submitter ⚠
- p.Leu108Val Single submitter ⚠
- p.Leu76Ile Single submitter ⚠
- p.Lys278Arg Single submitter ⚠
- p.Lys6Glu Single submitter ⚠
- p.Pro155Ser Single submitter ⚠
- p.Pro289Ala Single submitter ⚠
- p.Pro95Arg Single submitter ⚠
- p.Thr181Asn Single submitter ⚠
- p.Thr276Ala Single submitter ⚠
- p.Tyr107Cys Single submitter ⚠
- p.Tyr298Asp Single submitter ⚠
- p.Tyr77Cys Single submitter ⚠
- p.Val154Met Single submitter ⚠
- p.Val69Met Single submitter ⚠
- p.Val79Met Single submitter ⚠