CDK5R2 — 41 ClinVar variants
All ClinVar germline CDK5R2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 38 flagged for review →
2 Likely benign · 39 Uncertain significance
Full CDK5R2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 38
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 22
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CDK5R2 p.Ala133Thr Uncertain significance Single submitter
- CDK5R2 p.Ala144Ser Uncertain significance Single submitter
- CDK5R2 p.Arg200His Uncertain significance Single submitter
- CDK5R2 p.Arg248Cys Uncertain significance Single submitter
- CDK5R2 p.Arg248His Uncertain significance Single submitter
- CDK5R2 p.Asp110Glu Uncertain significance Single submitter
- CDK5R2 p.Gln164Pro Uncertain significance Single submitter
- CDK5R2 p.Gly149Ser Uncertain significance Single submitter
- CDK5R2 p.Gly149Val Uncertain significance Single submitter
- CDK5R2 p.Gly342Ala Uncertain significance Single submitter
- CDK5R2 p.Gly38Asp Uncertain significance Single submitter
- CDK5R2 p.Gly40Arg Uncertain significance Single submitter
- CDK5R2 p.His360Gln Uncertain significance Single submitter
- CDK5R2 p.Lys119Arg Uncertain significance Single submitter
- CDK5R2 p.Pro111Ala Uncertain significance Single submitter
- CDK5R2 p.Pro120Ala Uncertain significance Single submitter
- CDK5R2 p.Pro126Thr Uncertain significance Single submitter
- CDK5R2 p.Pro174Leu Uncertain significance Single submitter
- CDK5R2 p.Pro9Thr Uncertain significance Single submitter
- CDK5R2 p.Ser150Pro Uncertain significance Single submitter
- CDK5R2 p.Thr134Ser Uncertain significance Single submitter
- CDK5R2 p.Thr362Ala Uncertain significance Single submitter
Predictors split 16
The independent predictors disagree with each other — read with care.
- CDK5R2 p.Ala122Val Uncertain significance Single submitter
- CDK5R2 p.Ala261Ser Uncertain significance Single submitter
- CDK5R2 p.Ala331Pro Uncertain significance Single submitter
- CDK5R2 p.Gly115Cys Uncertain significance Single submitter
- CDK5R2 p.Gly116Asp Uncertain significance Single submitter
- CDK5R2 p.Gly337Asp Uncertain significance Single submitter
- CDK5R2 p.Pro148Leu Uncertain significance Single submitter
- CDK5R2 p.Pro159Leu Uncertain significance Single submitter
- CDK5R2 p.Pro161Leu Uncertain significance Single submitter
- CDK5R2 p.Ser150Leu Uncertain significance Single submitter
- CDK5R2 p.Ser173Leu Uncertain significance Single submitter
- CDK5R2 p.Ser348Leu Uncertain significance Single submitter
- CDK5R2 p.Thr65Ala Uncertain significance Single submitter
- CDK5R2 p.Val128Leu Uncertain significance Single submitter
- CDK5R2 p.Val70Leu Uncertain significance Single submitter
- CDK5R2 p.Val83Met Uncertain significance Single submitter
All CDK5R2 variants
Likely benign 2
- p.Pro344= Single submitter
- p.Thr358Ala Single submitter
Uncertain significance 39
- p.Ala122Val Single submitter ⚠
- p.Ala133Thr Single submitter ⚠
- p.Ala144Ser Single submitter ⚠
- p.Ala261Ser Single submitter ⚠
- p.Ala331Pro Single submitter ⚠
- p.Arg200His Single submitter ⚠
- p.Arg248Cys Single submitter ⚠
- p.Arg248His Single submitter ⚠
- p.Asp110Glu Single submitter ⚠
- p.Gln164Pro Single submitter ⚠
- p.Gly115Cys Single submitter ⚠
- p.Gly116Asp Single submitter ⚠
- p.Gly149Ser Single submitter ⚠
- p.Gly149Val Single submitter ⚠
- p.Gly337Asp Single submitter ⚠
- p.Gly342Ala Single submitter ⚠
- p.Gly38Asp Single submitter ⚠
- p.Gly40Arg Single submitter ⚠
- p.His360Gln Single submitter ⚠
- p.Lys119Arg Single submitter ⚠
- p.Pro111Ala Single submitter ⚠
- p.Pro120Ala Single submitter ⚠
- p.Pro126Thr Single submitter ⚠
- p.Pro148Leu Single submitter ⚠
- p.Pro159Leu Single submitter ⚠
- p.Pro161Leu Single submitter ⚠
- p.Pro174Leu Single submitter ⚠
- p.Pro9Thr Single submitter ⚠
- p.Ser150Leu Single submitter ⚠
- p.Ser150Pro Single submitter ⚠
- p.Ser173Leu Single submitter ⚠
- p.Ser348Leu Single submitter ⚠
- p.Thr134Ser Single submitter ⚠
- p.Thr362Ala Single submitter ⚠
- p.Thr65Ala Single submitter ⚠
- p.Val128Leu Single submitter ⚠
- p.Val70Leu Single submitter ⚠
- p.Val83Met Single submitter ⚠
- p.Gln98Ter No assertion criteria