CDK5RAP1 — 71 ClinVar variants
All ClinVar germline CDK5RAP1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 67 flagged for review →
3 Likely benign · 68 Uncertain significance
Full CDK5RAP1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 67
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 29
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CDK5RAP1 p.Ala247Val Uncertain significance Single submitter
- CDK5RAP1 p.Ala51Thr Uncertain significance Single submitter
- CDK5RAP1 p.Arg177Lys Uncertain significance Single submitter
- CDK5RAP1 p.Arg209Trp Uncertain significance Single submitter
- CDK5RAP1 p.Arg271Trp Uncertain significance Single submitter
- CDK5RAP1 p.Arg277Trp Uncertain significance Single submitter
- CDK5RAP1 p.Arg467Gln Uncertain significance Single submitter
- CDK5RAP1 p.Arg46Ser Uncertain significance Single submitter
- CDK5RAP1 p.Arg484Cys Uncertain significance Single submitter
- CDK5RAP1 p.Arg518Leu Uncertain significance Single submitter
- CDK5RAP1 p.Asn322Asp Uncertain significance Single submitter
- CDK5RAP1 p.Asp138Gly Uncertain significance Single submitter
- CDK5RAP1 p.Asp378Glu Uncertain significance Single submitter
- CDK5RAP1 p.Asp427Asn Uncertain significance Single submitter
- CDK5RAP1 p.Gln5Pro Uncertain significance Single submitter
- CDK5RAP1 p.Glu233Lys Uncertain significance Single submitter
- CDK5RAP1 p.His342Gln Uncertain significance Single submitter
- CDK5RAP1 p.His414Arg Uncertain significance Single submitter
- CDK5RAP1 p.His470Pro Uncertain significance Single submitter
- CDK5RAP1 p.Ile201Thr Uncertain significance Single submitter
- CDK5RAP1 p.Ile419Val Uncertain significance Single submitter
- CDK5RAP1 p.Leu141Phe Uncertain significance Single submitter
- CDK5RAP1 p.Lys125Gln Uncertain significance Single submitter
- CDK5RAP1 p.Met255Leu Uncertain significance Single submitter
- CDK5RAP1 p.Phe535Ser Uncertain significance Single submitter
- CDK5RAP1 p.Pro42Ser Uncertain significance Single submitter
- CDK5RAP1 p.Pro75Leu Uncertain significance Single submitter
- CDK5RAP1 p.Ser317Gly Uncertain significance Single submitter
- CDK5RAP1 p.Thr497Ala Uncertain significance Single submitter
Predictors split 38
The independent predictors disagree with each other — read with care.
- CDK5RAP1 p.Arg130Gln Uncertain significance Single submitter
- CDK5RAP1 p.Arg169Gln Uncertain significance Single submitter
- CDK5RAP1 p.Arg169Trp Uncertain significance Single submitter
- CDK5RAP1 p.Arg171Cys Uncertain significance Single submitter
- CDK5RAP1 p.Arg213Trp Uncertain significance Single submitter
- CDK5RAP1 p.Arg308Trp Uncertain significance Single submitter
- CDK5RAP1 p.Arg339Cys Uncertain significance Single submitter
- CDK5RAP1 p.Arg394Cys Uncertain significance Single submitter
- CDK5RAP1 p.Arg394His Uncertain significance Single submitter
- CDK5RAP1 p.Arg46Trp Uncertain significance Single submitter
- CDK5RAP1 p.Arg526Lys Uncertain significance Single submitter
- CDK5RAP1 p.Gln161Lys Uncertain significance Single submitter
- CDK5RAP1 p.Gln346Arg Uncertain significance Single submitter
- CDK5RAP1 p.Gln346His Uncertain significance Single submitter
- CDK5RAP1 p.Glu136Val Uncertain significance Single submitter
- CDK5RAP1 p.Glu438Gln Uncertain significance Single submitter
- CDK5RAP1 p.Glu539Gln Uncertain significance Single submitter
- CDK5RAP1 p.Glu94Gly Uncertain significance Single submitter
- CDK5RAP1 p.Gly221Asp Uncertain significance Single submitter
- CDK5RAP1 p.Gly434Arg Uncertain significance Single submitter
- CDK5RAP1 p.Ile140Val Uncertain significance Single submitter
- CDK5RAP1 p.Ile178Thr Uncertain significance Single submitter
- CDK5RAP1 p.Ile415Phe Uncertain significance Single submitter
- CDK5RAP1 p.Ile491Asn Uncertain significance Single submitter
- CDK5RAP1 p.Leu548Pro Uncertain significance Single submitter
- CDK5RAP1 p.Leu96Val Uncertain significance Single submitter
- CDK5RAP1 p.Met255Thr Uncertain significance Single submitter
- CDK5RAP1 p.Met462Val Uncertain significance Single submitter
- CDK5RAP1 p.Pro170Ser Uncertain significance Single submitter
- CDK5RAP1 p.Pro477Leu Uncertain significance Single submitter
- CDK5RAP1 p.Ser263Asn Uncertain significance Single submitter
- CDK5RAP1 p.Ser35Arg Uncertain significance Single submitter
- CDK5RAP1 p.Ser35Gly Uncertain significance Single submitter
- CDK5RAP1 p.Ser566Gly Uncertain significance Single submitter
- CDK5RAP1 p.Thr436Met Uncertain significance Single submitter
- CDK5RAP1 p.Tyr331Ser Uncertain significance Single submitter
- CDK5RAP1 p.Val227Met Uncertain significance Single submitter
- CDK5RAP1 p.Val22Met Uncertain significance Single submitter
All CDK5RAP1 variants
Likely benign 3
- p.Ala225= Single submitter
- p.Arg52Gln Single submitter
- p.Ile279Val Single submitter
Uncertain significance 68
- c.1107+5G>A Single submitter
- p.Ala247Val Single submitter ⚠
- p.Ala51Thr Single submitter ⚠
- p.Arg130Gln Single submitter ⚠
- p.Arg169Gln Single submitter ⚠
- p.Arg169Trp Single submitter ⚠
- p.Arg171Cys Single submitter ⚠
- p.Arg177Lys Single submitter ⚠
- p.Arg209Trp Single submitter ⚠
- p.Arg213Trp Single submitter ⚠
- p.Arg271Trp Single submitter ⚠
- p.Arg277Trp Single submitter ⚠
- p.Arg308Trp Single submitter ⚠
- p.Arg339Cys Single submitter ⚠
- p.Arg394Cys Single submitter ⚠
- p.Arg394His Single submitter ⚠
- p.Arg467Gln Single submitter ⚠
- p.Arg46Ser Single submitter ⚠
- p.Arg46Trp Single submitter ⚠
- p.Arg484Cys Single submitter ⚠
- p.Arg518Leu Single submitter ⚠
- p.Arg526Lys Single submitter ⚠
- p.Asn322Asp Single submitter ⚠
- p.Asp138Gly Single submitter ⚠
- p.Asp378Glu Single submitter ⚠
- p.Asp427Asn Single submitter ⚠
- p.Gln161Lys Single submitter ⚠
- p.Gln346Arg Single submitter ⚠
- p.Gln346His Single submitter ⚠
- p.Gln5Pro Single submitter ⚠
- p.Glu136Val Single submitter ⚠
- p.Glu233Lys Single submitter ⚠
- p.Glu438Gln Single submitter ⚠
- p.Glu539Gln Single submitter ⚠
- p.Glu94Gly Single submitter ⚠
- p.Gly221Asp Single submitter ⚠
- p.Gly434Arg Single submitter ⚠
- p.His342Gln Single submitter ⚠
- p.His414Arg Single submitter ⚠
- p.His470Pro Single submitter ⚠
- p.Ile140Val Single submitter ⚠
- p.Ile178Thr Single submitter ⚠
- p.Ile201Thr Single submitter ⚠
- p.Ile415Phe Single submitter ⚠
- p.Ile419Val Single submitter ⚠
- p.Ile491Asn Single submitter ⚠
- p.Leu141Phe Single submitter ⚠
- p.Leu548Pro Single submitter ⚠
- p.Leu96Val Single submitter ⚠
- p.Lys125Gln Single submitter ⚠
- p.Met255Leu Single submitter ⚠
- p.Met255Thr Single submitter ⚠
- p.Met462Val Single submitter ⚠
- p.Phe535Ser Single submitter ⚠
- p.Pro170Ser Single submitter ⚠
- p.Pro42Ser Single submitter ⚠
- p.Pro477Leu Single submitter ⚠
- p.Pro75Leu Single submitter ⚠
- p.Ser263Asn Single submitter ⚠
- p.Ser317Gly Single submitter ⚠
- p.Ser35Arg Single submitter ⚠
- p.Ser35Gly Single submitter ⚠
- p.Ser566Gly Single submitter ⚠
- p.Thr436Met Single submitter ⚠
- p.Thr497Ala Single submitter ⚠
- p.Tyr331Ser Single submitter ⚠
- p.Val227Met Single submitter ⚠
- p.Val22Met Single submitter ⚠