CDKL3 — 81 ClinVar variants
All ClinVar germline CDKL3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 77 flagged for review →
2 Benign · 3 Likely benign · 76 Uncertain significance
Full CDKL3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 77
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 60
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CDKL3 p.Ala195Thr Uncertain significance Single submitter
- CDKL3 p.Ala235Ser Uncertain significance Single submitter
- CDKL3 p.Arg111Pro Uncertain significance Single submitter
- CDKL3 p.Arg148Gln Uncertain significance Single submitter
- CDKL3 p.Arg164His Uncertain significance Single submitter
- CDKL3 p.Arg367Thr Uncertain significance Single submitter
- CDKL3 p.Arg463Ser Uncertain significance Single submitter
- CDKL3 p.Asn390Ser Uncertain significance Single submitter
- CDKL3 p.Asn410Ser Uncertain significance Single submitter
- CDKL3 p.Asn437Lys Uncertain significance Single submitter
- CDKL3 p.Asn564Lys Uncertain significance Single submitter
- CDKL3 p.Asp327Gly Uncertain significance Single submitter
- CDKL3 p.Cys142Gly Uncertain significance Single submitter
- CDKL3 p.Gln108Arg Uncertain significance Single submitter
- CDKL3 p.Gln268Pro Uncertain significance Single submitter
- CDKL3 p.Gln472Arg Uncertain significance Single submitter
- CDKL3 p.Glu306Lys Uncertain significance Single submitter
- CDKL3 p.Glu317Gln Uncertain significance Single submitter
- CDKL3 p.Glu496Lys Uncertain significance Single submitter
- CDKL3 p.Glu526Lys Uncertain significance Single submitter
- CDKL3 p.Gly218Ala Uncertain significance Single submitter
- CDKL3 p.Gly257Arg Uncertain significance Single submitter
- CDKL3 p.Gly344Arg Uncertain significance Single submitter
- CDKL3 p.Gly368Arg Uncertain significance Single submitter
- CDKL3 p.Gly426Ser Uncertain significance Single submitter
- CDKL3 p.His123Arg Uncertain significance Single submitter
- CDKL3 p.His282Arg Uncertain significance Single submitter
- CDKL3 p.His423Arg Uncertain significance Single submitter
- CDKL3 p.His59Gln Uncertain significance Single submitter
- CDKL3 p.His76Asn Uncertain significance Single submitter
- CDKL3 p.Ile113Val Uncertain significance Single submitter
- CDKL3 p.Ile121Phe Uncertain significance Single submitter
- CDKL3 p.Ile233Val Uncertain significance Single submitter
- CDKL3 p.Ile347Thr Uncertain significance Single submitter
- CDKL3 p.Ile347Val Uncertain significance Single submitter
- CDKL3 p.Leu440Phe Uncertain significance Single submitter
- CDKL3 p.Leu54Gln Uncertain significance Single submitter
- CDKL3 p.Leu562Phe Uncertain significance Single submitter
- CDKL3 p.Leu563Val Uncertain significance Single submitter
- CDKL3 p.Lys127Glu Uncertain significance Single submitter
- CDKL3 p.Lys140Glu Uncertain significance Single submitter
- CDKL3 p.Lys354Glu Uncertain significance Single submitter
- CDKL3 p.Lys375Asn Uncertain significance Single submitter
- CDKL3 p.Met190Lys Uncertain significance Single submitter
- CDKL3 p.Met394Val Uncertain significance Single submitter
- CDKL3 p.Phe522Ile Uncertain significance Single submitter
- CDKL3 p.Pro353Leu Uncertain significance Single submitter
- CDKL3 p.Pro406Leu Uncertain significance Single submitter
- CDKL3 p.Ser136Thr Uncertain significance Single submitter
- CDKL3 p.Ser276Leu Uncertain significance Single submitter
- CDKL3 p.Ser395Thr Uncertain significance Single submitter
- CDKL3 p.Ser501Gly Uncertain significance Single submitter
- CDKL3 p.Thr158Met Uncertain significance Single submitter
- CDKL3 p.Thr85Arg Uncertain significance Single submitter
- CDKL3 p.Tyr157Asn Uncertain significance Single submitter
- CDKL3 p.Tyr15Ser Uncertain significance Single submitter
- CDKL3 p.Tyr160Cys Uncertain significance Single submitter
- CDKL3 p.Tyr200Cys Uncertain significance Single submitter
- CDKL3 p.Val473Ile Uncertain significance Single submitter
- CDKL3 p.Val565Met Uncertain significance Single submitter
Predictors split 17
The independent predictors disagree with each other — read with care.
- CDKL3 p.Arg101Gln Uncertain significance Single submitter
- CDKL3 p.Arg464Cys Uncertain significance Single submitter
- CDKL3 p.Asn119Asp Uncertain significance Single submitter
- CDKL3 p.Asp270Asn Uncertain significance Single submitter
- CDKL3 p.Glu129Asp Uncertain significance Single submitter
- CDKL3 p.Glu98Ala Uncertain significance Single submitter
- CDKL3 p.Gly8Glu Uncertain significance Single submitter
- CDKL3 p.His84Arg Uncertain significance Single submitter
- CDKL3 p.Ile262Thr Uncertain significance Single submitter
- CDKL3 p.Ile32Val Uncertain significance Single submitter
- CDKL3 p.Ile46Phe Uncertain significance Single submitter
- CDKL3 p.Leu343Trp Uncertain significance Single submitter
- CDKL3 p.Leu563Phe Uncertain significance Single submitter
- CDKL3 p.Leu7Phe Uncertain significance Single submitter
- CDKL3 p.Pro253Ala Uncertain significance Single submitter
- CDKL3 p.Ser118Asn Likely benign Single submitter
- CDKL3 p.Tyr115Cys Uncertain significance Single submitter
All CDKL3 variants
Likely benign 3
- p.Glu580Lys Single submitter
- p.Ser118Asn Single submitter ⚠
- p.Ser371Leu Single submitter
Uncertain significance 76
- p.Ala195Thr Single submitter ⚠
- p.Ala235Ser Single submitter ⚠
- p.Arg101Gln Single submitter ⚠
- p.Arg111Pro Single submitter ⚠
- p.Arg148Gln Single submitter ⚠
- p.Arg164His Single submitter ⚠
- p.Arg367Thr Single submitter ⚠
- p.Arg463Ser Single submitter ⚠
- p.Arg464Cys Single submitter ⚠
- p.Asn119Asp Single submitter ⚠
- p.Asn390Ser Single submitter ⚠
- p.Asn410Ser Single submitter ⚠
- p.Asn437Lys Single submitter ⚠
- p.Asn564Lys Single submitter ⚠
- p.Asp270Asn Single submitter ⚠
- p.Asp327Gly Single submitter ⚠
- p.Cys142Gly Single submitter ⚠
- p.Gln108Arg Single submitter ⚠
- p.Gln268Pro Single submitter ⚠
- p.Gln472Arg Single submitter ⚠
- p.Glu129Asp Single submitter ⚠
- p.Glu306Lys Single submitter ⚠
- p.Glu317Gln Single submitter ⚠
- p.Glu496Lys Single submitter ⚠
- p.Glu526Lys Single submitter ⚠
- p.Glu98Ala Single submitter ⚠
- p.Gly218Ala Single submitter ⚠
- p.Gly257Arg Single submitter ⚠
- p.Gly344Arg Single submitter ⚠
- p.Gly368Arg Single submitter ⚠
- p.Gly426Ser Single submitter ⚠
- p.Gly8Glu Single submitter ⚠
- p.His123Arg Single submitter ⚠
- p.His282Arg Single submitter ⚠
- p.His423Arg Single submitter ⚠
- p.His59Gln Single submitter ⚠
- p.His76Asn Single submitter ⚠
- p.His84Arg Single submitter ⚠
- p.Ile113Val Single submitter ⚠
- p.Ile121Phe Single submitter ⚠
- p.Ile233Val Single submitter ⚠
- p.Ile262Thr Single submitter ⚠
- p.Ile32Val Single submitter ⚠
- p.Ile347Thr Single submitter ⚠
- p.Ile347Val Single submitter ⚠
- p.Ile46Phe Single submitter ⚠
- p.Leu343Trp Single submitter ⚠
- p.Leu440Phe Single submitter ⚠
- p.Leu54Gln Single submitter ⚠
- p.Leu562Phe Single submitter ⚠
- p.Leu563Phe Single submitter ⚠
- p.Leu563Val Single submitter ⚠
- p.Leu7Phe Single submitter ⚠
- p.Lys127Glu Single submitter ⚠
- p.Lys140Glu Single submitter ⚠
- p.Lys354Glu Single submitter ⚠
- p.Lys375Asn Single submitter ⚠
- p.Met190Lys Single submitter ⚠
- p.Met394Val Single submitter ⚠
- p.Phe522Ile Single submitter ⚠
- p.Pro253Ala Single submitter ⚠
- p.Pro353Leu Single submitter ⚠
- p.Pro406Leu Single submitter ⚠
- p.Ser136Thr Single submitter ⚠
- p.Ser276Leu Single submitter ⚠
- p.Ser395Thr Single submitter ⚠
- p.Ser501Gly Single submitter ⚠
- p.Thr158Met Single submitter ⚠
- p.Thr85Arg Single submitter ⚠
- p.Tyr115Cys Single submitter ⚠
- p.Tyr157Asn Single submitter ⚠
- p.Tyr15Ser Single submitter ⚠
- p.Tyr160Cys Single submitter ⚠
- p.Tyr200Cys Single submitter ⚠
- p.Val473Ile Single submitter ⚠
- p.Val565Met Single submitter ⚠