CDKL4 — 38 ClinVar variants
All ClinVar germline CDKL4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 38 flagged for review →
38 Uncertain significance
Full CDKL4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 38
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 15
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CDKL4 p.Asp254His Uncertain significance Single submitter
- CDKL4 p.Gln177Lys Uncertain significance Single submitter
- CDKL4 p.Gly16Arg Uncertain significance Single submitter
- CDKL4 p.His120Arg Uncertain significance Single submitter
- CDKL4 p.Ile123Ser Uncertain significance Single submitter
- CDKL4 p.Leu171Pro Uncertain significance Single submitter
- CDKL4 p.Lys251Arg Uncertain significance Single submitter
- CDKL4 p.Lys75Arg Uncertain significance Single submitter
- CDKL4 p.Met245Val Uncertain significance Single submitter
- CDKL4 p.Phe286Ser Uncertain significance Single submitter
- CDKL4 p.Pro169Ser Uncertain significance Single submitter
- CDKL4 p.Ser105Arg Uncertain significance Single submitter
- CDKL4 p.Ser230Thr Uncertain significance Single submitter
- CDKL4 p.Thr10Ala Uncertain significance Single submitter
- CDKL4 p.Trp185Arg Uncertain significance Single submitter
Predictors split 23
The independent predictors disagree with each other — read with care.
- CDKL4 p.Ala168Pro Uncertain significance Single submitter
- CDKL4 p.Ala186Thr Uncertain significance Single submitter
- CDKL4 p.Arg167Gln Uncertain significance Single submitter
- CDKL4 p.Arg299Cys Uncertain significance Single submitter
- CDKL4 p.Asn62Ser Uncertain significance Single submitter
- CDKL4 p.Asn65Thr Uncertain significance Single submitter
- CDKL4 p.Asn94Lys Uncertain significance Single submitter
- CDKL4 p.Asp159Asn Uncertain significance Single submitter
- CDKL4 p.Asp175Gly Uncertain significance Single submitter
- CDKL4 p.Asp183Asn Uncertain significance Single submitter
- CDKL4 p.Asp273Gly Uncertain significance Single submitter
- CDKL4 p.Asp84Asn Uncertain significance Single submitter
- CDKL4 p.Glu249Gly Uncertain significance Single submitter
- CDKL4 p.Glu39Lys Uncertain significance Single submitter
- CDKL4 p.Glu92Gly Uncertain significance Single submitter
- CDKL4 p.Ile184Met Uncertain significance Single submitter
- CDKL4 p.Leu111Phe Uncertain significance Single submitter
- CDKL4 p.Leu200Pro Uncertain significance Single submitter
- CDKL4 p.Leu91Val Uncertain significance Single submitter
- CDKL4 p.Phe35Ile Uncertain significance Single submitter
- CDKL4 p.Ser180Phe Uncertain significance Single submitter
- CDKL4 p.Ser38Pro Uncertain significance Single submitter
- CDKL4 p.Val182Ile Uncertain significance Single submitter
All CDKL4 variants
Uncertain significance 38
- p.Ala168Pro Single submitter ⚠
- p.Ala186Thr Single submitter ⚠
- p.Arg167Gln Single submitter ⚠
- p.Arg299Cys Single submitter ⚠
- p.Asn62Ser Single submitter ⚠
- p.Asn65Thr Single submitter ⚠
- p.Asn94Lys Single submitter ⚠
- p.Asp159Asn Single submitter ⚠
- p.Asp175Gly Single submitter ⚠
- p.Asp183Asn Single submitter ⚠
- p.Asp254His Single submitter ⚠
- p.Asp273Gly Single submitter ⚠
- p.Asp84Asn Single submitter ⚠
- p.Gln177Lys Single submitter ⚠
- p.Glu249Gly Single submitter ⚠
- p.Glu39Lys Single submitter ⚠
- p.Glu92Gly Single submitter ⚠
- p.Gly16Arg Single submitter ⚠
- p.His120Arg Single submitter ⚠
- p.Ile123Ser Single submitter ⚠
- p.Ile184Met Single submitter ⚠
- p.Leu111Phe Single submitter ⚠
- p.Leu171Pro Single submitter ⚠
- p.Leu200Pro Single submitter ⚠
- p.Leu91Val Single submitter ⚠
- p.Lys251Arg Single submitter ⚠
- p.Lys75Arg Single submitter ⚠
- p.Met245Val Single submitter ⚠
- p.Phe286Ser Single submitter ⚠
- p.Phe35Ile Single submitter ⚠
- p.Pro169Ser Single submitter ⚠
- p.Ser105Arg Single submitter ⚠
- p.Ser180Phe Single submitter ⚠
- p.Ser230Thr Single submitter ⚠
- p.Ser38Pro Single submitter ⚠
- p.Thr10Ala Single submitter ⚠
- p.Trp185Arg Single submitter ⚠
- p.Val182Ile Single submitter ⚠