CDKN2AIP — 88 ClinVar variants
All ClinVar germline CDKN2AIP variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 87 flagged for review →
1 Likely benign · 87 Uncertain significance
Full CDKN2AIP gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 87
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 39
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CDKN2AIP p.Ala104Ser Uncertain significance Single submitter
- CDKN2AIP p.Ala163Thr Uncertain significance Single submitter
- CDKN2AIP p.Ala315Ser Uncertain significance Single submitter
- CDKN2AIP p.Ala47Val Uncertain significance Single submitter
- CDKN2AIP p.Ala55Pro Uncertain significance Single submitter
- CDKN2AIP p.Arg208Leu Uncertain significance Single submitter
- CDKN2AIP p.Arg91Gly Uncertain significance Single submitter
- CDKN2AIP p.Asn189Ile Uncertain significance Single submitter
- CDKN2AIP p.Asn430Ser Uncertain significance Single submitter
- CDKN2AIP p.Asp111Asn Uncertain significance Single submitter
- CDKN2AIP p.Asp261Val Uncertain significance Single submitter
- CDKN2AIP p.Asp98His Uncertain significance Single submitter
- CDKN2AIP p.Cys24Ser Uncertain significance Single submitter
- CDKN2AIP p.Gln213Leu Uncertain significance Single submitter
- CDKN2AIP p.Gln283His Uncertain significance Single submitter
- CDKN2AIP p.Glu186Lys Uncertain significance Single submitter
- CDKN2AIP p.Gly240Asp Uncertain significance Single submitter
- CDKN2AIP p.Gly294Asp Uncertain significance Single submitter
- CDKN2AIP p.Gly341Asp Uncertain significance Single submitter
- CDKN2AIP p.Gly464Ala Uncertain significance Single submitter
- CDKN2AIP p.Gly50Ser Uncertain significance Single submitter
- CDKN2AIP p.Ile146Met Uncertain significance Single submitter
- CDKN2AIP p.Ile183Leu Uncertain significance Single submitter
- CDKN2AIP p.Lys108Gln Uncertain significance Single submitter
- CDKN2AIP p.Lys271Arg Uncertain significance Single submitter
- CDKN2AIP p.Met256Ile Uncertain significance Single submitter
- CDKN2AIP p.Pro310Ser Uncertain significance Single submitter
- CDKN2AIP p.Pro347Ser Uncertain significance Single submitter
- CDKN2AIP p.Pro410Leu Uncertain significance Single submitter
- CDKN2AIP p.Ser254Gly Uncertain significance Single submitter
- CDKN2AIP p.Ser296Leu Uncertain significance Single submitter
- CDKN2AIP p.Thr110Ile Uncertain significance Single submitter
- CDKN2AIP p.Thr114Ala Uncertain significance Single submitter
- CDKN2AIP p.Thr116Ile Uncertain significance Single submitter
- CDKN2AIP p.Thr57Ala Uncertain significance Single submitter
- CDKN2AIP p.Thr57Arg Uncertain significance Single submitter
- CDKN2AIP p.Val137Ile Uncertain significance Single submitter
- CDKN2AIP p.Val210Leu Uncertain significance Single submitter
- CDKN2AIP p.Val422Ile Uncertain significance Single submitter
Predictors split 48
The independent predictors disagree with each other — read with care.
- CDKN2AIP p.Ala281Pro Uncertain significance Single submitter
- CDKN2AIP p.Ala327Gly Uncertain significance Single submitter
- CDKN2AIP p.Ala367Val Uncertain significance Single submitter
- CDKN2AIP p.Ala53Val Uncertain significance Single submitter
- CDKN2AIP p.Asp62Asn Uncertain significance Single submitter
- CDKN2AIP p.Cys178Trp Uncertain significance Single submitter
- CDKN2AIP p.Gln365Arg Uncertain significance Single submitter
- CDKN2AIP p.Gln94Leu Uncertain significance Single submitter
- CDKN2AIP p.Glu302Gln Uncertain significance Single submitter
- CDKN2AIP p.Gly341Arg Uncertain significance Single submitter
- CDKN2AIP p.His463Tyr Uncertain significance Single submitter
- CDKN2AIP p.Ile196Met Uncertain significance Single submitter
- CDKN2AIP p.Leu101Phe Uncertain significance Single submitter
- CDKN2AIP p.Leu247Met Uncertain significance Single submitter
- CDKN2AIP p.Leu292Phe Uncertain significance Single submitter
- CDKN2AIP p.Leu303Phe Uncertain significance Single submitter
- CDKN2AIP p.Leu358Pro Uncertain significance Single submitter
- CDKN2AIP p.Met80Val Uncertain significance Single submitter
- CDKN2AIP p.Phe457Cys Uncertain significance Single submitter
- CDKN2AIP p.Phe482Cys Uncertain significance Single submitter
- CDKN2AIP p.Ser152Phe Uncertain significance Single submitter
- CDKN2AIP p.Ser175Asn Uncertain significance Single submitter
- CDKN2AIP p.Ser176Pro Uncertain significance Single submitter
- CDKN2AIP p.Ser201Asn Uncertain significance Single submitter
- CDKN2AIP p.Ser202Phe Uncertain significance Single submitter
- CDKN2AIP p.Ser211Phe Uncertain significance Single submitter
- CDKN2AIP p.Ser212Thr Uncertain significance Single submitter
- CDKN2AIP p.Ser243Leu Uncertain significance Single submitter
- CDKN2AIP p.Ser259Cys Uncertain significance Single submitter
- CDKN2AIP p.Ser262Thr Uncertain significance Single submitter
- CDKN2AIP p.Ser277Phe Uncertain significance Single submitter
- CDKN2AIP p.Ser282Cys Uncertain significance Single submitter
- CDKN2AIP p.Ser321Pro Uncertain significance Single submitter
- CDKN2AIP p.Ser324Arg Uncertain significance Single submitter
- CDKN2AIP p.Ser324Thr Uncertain significance Single submitter
- CDKN2AIP p.Ser325Leu Uncertain significance Single submitter
- CDKN2AIP p.Ser360Phe Uncertain significance Single submitter
- CDKN2AIP p.Ser362Arg Uncertain significance Single submitter
- CDKN2AIP p.Ser369Leu Uncertain significance Single submitter
- CDKN2AIP p.Ser382Phe Uncertain significance Single submitter
- CDKN2AIP p.Ser392Thr Uncertain significance Single submitter
- CDKN2AIP p.Ser402Pro Uncertain significance Single submitter
- CDKN2AIP p.Ser420Gly Uncertain significance Single submitter
- CDKN2AIP p.Thr257Ile Uncertain significance Single submitter
- CDKN2AIP p.Val422Phe Uncertain significance Single submitter
- CDKN2AIP p.Val540Leu Uncertain significance Single submitter
- CDKN2AIP p.Val5Met Uncertain significance Single submitter
-
CDKN2AIP p.Leu305Arg
Uncertain significance
No assertion criteria
prostate cancer
All CDKN2AIP variants
Likely benign 1
- p.Leu88= Single submitter
Uncertain significance 87
- p.Ala104Ser Single submitter ⚠
- p.Ala163Thr Single submitter ⚠
- p.Ala281Pro Single submitter ⚠
- p.Ala315Ser Single submitter ⚠
- p.Ala327Gly Single submitter ⚠
- p.Ala367Val Single submitter ⚠
- p.Ala47Val Single submitter ⚠
- p.Ala53Val Single submitter ⚠
- p.Ala55Pro Single submitter ⚠
- p.Arg208Leu Single submitter ⚠
- p.Arg91Gly Single submitter ⚠
- p.Asn189Ile Single submitter ⚠
- p.Asn430Ser Single submitter ⚠
- p.Asp111Asn Single submitter ⚠
- p.Asp261Val Single submitter ⚠
- p.Asp62Asn Single submitter ⚠
- p.Asp98His Single submitter ⚠
- p.Cys178Trp Single submitter ⚠
- p.Cys24Ser Single submitter ⚠
- p.Gln213Leu Single submitter ⚠
- p.Gln283His Single submitter ⚠
- p.Gln365Arg Single submitter ⚠
- p.Gln94Leu Single submitter ⚠
- p.Glu186Lys Single submitter ⚠
- p.Glu302Gln Single submitter ⚠
- p.Gly240Asp Single submitter ⚠
- p.Gly294Asp Single submitter ⚠
- p.Gly341Arg Single submitter ⚠
- p.Gly341Asp Single submitter ⚠
- p.Gly464Ala Single submitter ⚠
- p.Gly50Ser Single submitter ⚠
- p.His463Tyr Single submitter ⚠
- p.Ile146Met Single submitter ⚠
- p.Ile183Leu Single submitter ⚠
- p.Ile196Met Single submitter ⚠
- p.Leu101Phe Single submitter ⚠
- p.Leu247Met Single submitter ⚠
- p.Leu292Phe Single submitter ⚠
- p.Leu303Phe Single submitter ⚠
- p.Leu358Pro Single submitter ⚠
- p.Lys108Gln Single submitter ⚠
- p.Lys271Arg Single submitter ⚠
- p.Met256Ile Single submitter ⚠
- p.Met80Val Single submitter ⚠
- p.Phe457Cys Single submitter ⚠
- p.Phe482Cys Single submitter ⚠
- p.Pro310Ser Single submitter ⚠
- p.Pro347Ser Single submitter ⚠
- p.Pro410Leu Single submitter ⚠
- p.Ser152Phe Single submitter ⚠
- p.Ser175Asn Single submitter ⚠
- p.Ser176Pro Single submitter ⚠
- p.Ser201Asn Single submitter ⚠
- p.Ser202Phe Single submitter ⚠
- p.Ser211Phe Single submitter ⚠
- p.Ser212Thr Single submitter ⚠
- p.Ser243Leu Single submitter ⚠
- p.Ser254Gly Single submitter ⚠
- p.Ser259Cys Single submitter ⚠
- p.Ser262Thr Single submitter ⚠
- p.Ser277Phe Single submitter ⚠
- p.Ser282Cys Single submitter ⚠
- p.Ser296Leu Single submitter ⚠
- p.Ser321Pro Single submitter ⚠
- p.Ser324Arg Single submitter ⚠
- p.Ser324Thr Single submitter ⚠
- p.Ser325Leu Single submitter ⚠
- p.Ser360Phe Single submitter ⚠
- p.Ser362Arg Single submitter ⚠
- p.Ser369Leu Single submitter ⚠
- p.Ser382Phe Single submitter ⚠
- p.Ser392Thr Single submitter ⚠
- p.Ser402Pro Single submitter ⚠
- p.Ser420Gly Single submitter ⚠
- p.Thr110Ile Single submitter ⚠
- p.Thr114Ala Single submitter ⚠
- p.Thr116Ile Single submitter ⚠
- p.Thr257Ile Single submitter ⚠
- p.Thr57Ala Single submitter ⚠
- p.Thr57Arg Single submitter ⚠
- p.Val137Ile Single submitter ⚠
- p.Val210Leu Single submitter ⚠
- p.Val422Ile Single submitter ⚠
- p.Val422Phe Single submitter ⚠
- p.Val540Leu Single submitter ⚠
- p.Val5Met Single submitter ⚠
- p.Leu305Arg No assertion criteria prostate cancer ⚠