CDKN2AIPNL — 16 ClinVar variants
All ClinVar germline CDKN2AIPNL variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 15 flagged for review →
1 Likely benign · 15 Uncertain significance
Full CDKN2AIPNL gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 15
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 13
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CDKN2AIPNL p.Ala6Val Uncertain significance Single submitter
- CDKN2AIPNL p.Ala7Thr Uncertain significance Single submitter
- CDKN2AIPNL p.Arg52Gly Uncertain significance Single submitter
- CDKN2AIPNL p.Asn73Ser Uncertain significance Single submitter
- CDKN2AIPNL p.Asn82Ser Uncertain significance Single submitter
- CDKN2AIPNL p.Glu109Gly Uncertain significance Single submitter
- CDKN2AIPNL p.Glu11Gly Uncertain significance Single submitter
- CDKN2AIPNL p.Gly16Glu Uncertain significance Single submitter
- CDKN2AIPNL p.Gly95Arg Uncertain significance Single submitter
- CDKN2AIPNL p.Ile44Leu Uncertain significance Single submitter
- CDKN2AIPNL p.Ile44Val Uncertain significance Single submitter
- CDKN2AIPNL p.Val10Met Uncertain significance Single submitter
- CDKN2AIPNL p.Val14Ile Uncertain significance Single submitter
Predictors split 2
The independent predictors disagree with each other — read with care.
All CDKN2AIPNL variants
Likely benign 1
- p.Ala21Thr Single submitter
Uncertain significance 15
- p.Ala6Val Single submitter ⚠
- p.Ala7Thr Single submitter ⚠
- p.Arg52Gly Single submitter ⚠
- p.Asn73Ser Single submitter ⚠
- p.Asn82Ser Single submitter ⚠
- p.Glu109Gly Single submitter ⚠
- p.Glu11Gly Single submitter ⚠
- p.Gly16Glu Single submitter ⚠
- p.Gly95Arg Single submitter ⚠
- p.Ile44Leu Single submitter ⚠
- p.Ile44Val Single submitter ⚠
- p.Met69Val Single submitter ⚠
- p.Ser108Ile Single submitter ⚠
- p.Val10Met Single submitter ⚠
- p.Val14Ile Single submitter ⚠