CDKN2D — 14 ClinVar variants
All ClinVar germline CDKN2D variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 14 flagged for review →
14 Uncertain significance
Full CDKN2D gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 14
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 4
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
Predictors split 10
The independent predictors disagree with each other — read with care.
- CDKN2D p.Ala137Pro Uncertain significance Single submitter
- CDKN2D p.Ala57Thr Uncertain significance Single submitter
- CDKN2D p.Arg7Pro Uncertain significance Single submitter
- CDKN2D p.Arg83Cys Uncertain significance Single submitter
- CDKN2D p.Gln152Pro Uncertain significance Single submitter
- CDKN2D p.Glu23Gln Uncertain significance Single submitter
- CDKN2D p.Glu4Lys Uncertain significance Single submitter
- CDKN2D p.Gly107Arg Uncertain significance Single submitter
- CDKN2D p.Gly74Ser Uncertain significance Single submitter
- CDKN2D p.Leu143Val Uncertain significance Single submitter
All CDKN2D variants
Uncertain significance 14
- p.Ala128Pro Single submitter ⚠
- p.Ala137Pro Single submitter ⚠
- p.Ala146Thr Single submitter ⚠
- p.Ala57Thr Single submitter ⚠
- p.Arg7Pro Single submitter ⚠
- p.Arg83Cys Single submitter ⚠
- p.Asp20Asn Single submitter ⚠
- p.Gln152Pro Single submitter ⚠
- p.Glu23Gln Single submitter ⚠
- p.Glu4Lys Single submitter ⚠
- p.Gly107Arg Single submitter ⚠
- p.Gly74Ser Single submitter ⚠
- p.Leu143Val Single submitter ⚠
- p.Val102Met Single submitter ⚠