CDKN3 — 11 ClinVar variants
All ClinVar germline CDKN3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 11 flagged for review →
11 Uncertain significance
Full CDKN3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 11
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 4
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
Predictors split 7
The independent predictors disagree with each other — read with care.
- CDKN3 p.Arg193Trp Uncertain significance Single submitter
- CDKN3 p.Asn91Lys Uncertain significance Single submitter
- CDKN3 p.Gln166His Uncertain significance Single submitter
- CDKN3 p.Glu124Gly Uncertain significance Single submitter
- CDKN3 p.Glu125Asp Uncertain significance Single submitter
- CDKN3 p.Ile29Met Uncertain significance Single submitter
- CDKN3 p.Ile75Met Uncertain significance Single submitter
All CDKN3 variants
Uncertain significance 11
- p.Ala179Thr Single submitter ⚠
- p.Arg193Trp Single submitter ⚠
- p.Asn91Lys Single submitter ⚠
- p.Gln166His Single submitter ⚠
- p.Glu124Gly Single submitter ⚠
- p.Glu125Asp Single submitter ⚠
- p.Ile29Met Single submitter ⚠
- p.Ile75Met Single submitter ⚠
- p.Ile7Met Single submitter ⚠
- p.Leu45Val Single submitter ⚠
- p.Lys62Arg Single submitter ⚠