CDR2 — 72 ClinVar variants
All ClinVar germline CDR2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 67 flagged for review →
5 Likely benign · 67 Uncertain significance
Full CDR2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 67
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 40
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CDR2 p.Ala107Val Uncertain significance Single submitter
- CDR2 p.Ala155Thr Uncertain significance Single submitter
- CDR2 p.Ala178Thr Uncertain significance Single submitter
- CDR2 p.Ala319Ser Uncertain significance Single submitter
- CDR2 p.Ala355Thr Uncertain significance Single submitter
- CDR2 p.Ala394Thr Uncertain significance Single submitter
- CDR2 p.Arg213Gln Uncertain significance Single submitter
- CDR2 p.Arg244Gln Uncertain significance Single submitter
- CDR2 p.Arg308Leu Uncertain significance Single submitter
- CDR2 p.Arg41Gly Uncertain significance Single submitter
- CDR2 p.Arg448Gln Uncertain significance Single submitter
- CDR2 p.Asn125Ser Uncertain significance Single submitter
- CDR2 p.Asn195Lys Uncertain significance Single submitter
- CDR2 p.Asp20Asn Uncertain significance Single submitter
- CDR2 p.Cys149Ser Uncertain significance Single submitter
- CDR2 p.Cys149Tyr Uncertain significance Single submitter
- CDR2 p.Gln262His Uncertain significance Single submitter
- CDR2 p.Gln288Arg Uncertain significance Single submitter
- CDR2 p.Gln395Arg Uncertain significance Single submitter
- CDR2 p.Gln99Arg Uncertain significance Single submitter
- CDR2 p.Glu14Asp Uncertain significance Single submitter
- CDR2 p.Glu196Lys Uncertain significance Single submitter
- CDR2 p.Glu328Lys Uncertain significance Single submitter
- CDR2 p.Glu370Gln Uncertain significance Single submitter
- CDR2 p.Gly320Glu Uncertain significance Single submitter
- CDR2 p.Gly326Ser Uncertain significance Single submitter
- CDR2 p.Gly402Cys Uncertain significance Single submitter
- CDR2 p.His347Arg Uncertain significance Single submitter
- CDR2 p.Ile440Thr Uncertain significance Single submitter
- CDR2 p.Met12Ile Uncertain significance Single submitter
- CDR2 p.Pro146Leu Uncertain significance Single submitter
- CDR2 p.Pro146Thr Uncertain significance Single submitter
- CDR2 p.Ser311Arg Uncertain significance Single submitter
- CDR2 p.Ser354Arg Uncertain significance Single submitter
- CDR2 p.Thr124Ser Uncertain significance Single submitter
- CDR2 p.Thr54Ile Uncertain significance Single submitter
- CDR2 p.Tyr447Phe Uncertain significance Single submitter
- CDR2 p.Val226Leu Uncertain significance Single submitter
- CDR2 p.Val275Met Uncertain significance Single submitter
- CDR2 p.Val413Leu Uncertain significance Single submitter
Predictors split 27
The independent predictors disagree with each other — read with care.
- CDR2 p.Ala252Pro Uncertain significance Single submitter
- CDR2 p.Arg216Gln Uncertain significance Single submitter
- CDR2 p.Arg308Cys Uncertain significance Single submitter
- CDR2 p.Arg74Gln Uncertain significance Single submitter
- CDR2 p.Asp166His Uncertain significance Single submitter
- CDR2 p.Asp277Tyr Uncertain significance Single submitter
- CDR2 p.Gln26Pro Uncertain significance Single submitter
- CDR2 p.Gln75Lys Uncertain significance Single submitter
- CDR2 p.Glu16Lys Uncertain significance Single submitter
- CDR2 p.Glu253Lys Uncertain significance Single submitter
- CDR2 p.Glu362Lys Uncertain significance Single submitter
- CDR2 p.Ile119Thr Uncertain significance Single submitter
- CDR2 p.Ile126Thr Uncertain significance Single submitter
- CDR2 p.Leu129Phe Uncertain significance Single submitter
- CDR2 p.Leu315Phe Uncertain significance Single submitter
- CDR2 p.Pro17Gln Uncertain significance Single submitter
- CDR2 p.Pro17Ser Uncertain significance Single submitter
- CDR2 p.Pro420Leu Uncertain significance Single submitter
- CDR2 p.Ser309Gly Uncertain significance Single submitter
- CDR2 p.Ser415Phe Uncertain significance Single submitter
- CDR2 p.Ser431Thr Uncertain significance Single submitter
- CDR2 p.Ser454Tyr Uncertain significance Single submitter
- CDR2 p.Thr436Ser Uncertain significance Single submitter
- CDR2 p.Thr67Met Uncertain significance Single submitter
- CDR2 p.Tyr243Asn Uncertain significance Single submitter
- CDR2 p.Val133Gly Uncertain significance Single submitter
- CDR2 p.Val413Met Uncertain significance Single submitter
All CDR2 variants
Likely benign 5
- p.Gln22Arg Single submitter
- p.Gly402Ser Single submitter
- p.Leu6= Single submitter
- p.Phe295Leu Single submitter
- p.Pro154Ser Single submitter
Uncertain significance 67
- p.Ala107Val Single submitter ⚠
- p.Ala155Thr Single submitter ⚠
- p.Ala178Thr Single submitter ⚠
- p.Ala252Pro Single submitter ⚠
- p.Ala319Ser Single submitter ⚠
- p.Ala355Thr Single submitter ⚠
- p.Ala394Thr Single submitter ⚠
- p.Arg213Gln Single submitter ⚠
- p.Arg216Gln Single submitter ⚠
- p.Arg244Gln Single submitter ⚠
- p.Arg308Cys Single submitter ⚠
- p.Arg308Leu Single submitter ⚠
- p.Arg41Gly Single submitter ⚠
- p.Arg448Gln Single submitter ⚠
- p.Arg74Gln Single submitter ⚠
- p.Asn125Ser Single submitter ⚠
- p.Asn195Lys Single submitter ⚠
- p.Asp166His Single submitter ⚠
- p.Asp20Asn Single submitter ⚠
- p.Asp277Tyr Single submitter ⚠
- p.Cys149Ser Single submitter ⚠
- p.Cys149Tyr Single submitter ⚠
- p.Gln262His Single submitter ⚠
- p.Gln26Pro Single submitter ⚠
- p.Gln288Arg Single submitter ⚠
- p.Gln395Arg Single submitter ⚠
- p.Gln75Lys Single submitter ⚠
- p.Gln99Arg Single submitter ⚠
- p.Glu14Asp Single submitter ⚠
- p.Glu16Lys Single submitter ⚠
- p.Glu196Lys Single submitter ⚠
- p.Glu253Lys Single submitter ⚠
- p.Glu328Lys Single submitter ⚠
- p.Glu362Lys Single submitter ⚠
- p.Glu370Gln Single submitter ⚠
- p.Gly320Glu Single submitter ⚠
- p.Gly326Ser Single submitter ⚠
- p.Gly402Cys Single submitter ⚠
- p.His347Arg Single submitter ⚠
- p.Ile119Thr Single submitter ⚠
- p.Ile126Thr Single submitter ⚠
- p.Ile440Thr Single submitter ⚠
- p.Leu129Phe Single submitter ⚠
- p.Leu315Phe Single submitter ⚠
- p.Met12Ile Single submitter ⚠
- p.Pro146Leu Single submitter ⚠
- p.Pro146Thr Single submitter ⚠
- p.Pro17Gln Single submitter ⚠
- p.Pro17Ser Single submitter ⚠
- p.Pro420Leu Single submitter ⚠
- p.Ser309Gly Single submitter ⚠
- p.Ser311Arg Single submitter ⚠
- p.Ser354Arg Single submitter ⚠
- p.Ser415Phe Single submitter ⚠
- p.Ser431Thr Single submitter ⚠
- p.Ser454Tyr Single submitter ⚠
- p.Thr124Ser Single submitter ⚠
- p.Thr436Ser Single submitter ⚠
- p.Thr54Ile Single submitter ⚠
- p.Thr67Met Single submitter ⚠
- p.Tyr243Asn Single submitter ⚠
- p.Tyr447Phe Single submitter ⚠
- p.Val133Gly Single submitter ⚠
- p.Val226Leu Single submitter ⚠
- p.Val275Met Single submitter ⚠
- p.Val413Leu Single submitter ⚠
- p.Val413Met Single submitter ⚠