CDR2L — 66 ClinVar variants
All ClinVar germline CDR2L variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 66 flagged for review →
66 Uncertain significance
Full CDR2L gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 66
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 43
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CDR2L p.Ala201Glu Uncertain significance Single submitter
- CDR2L p.Ala222Thr Uncertain significance Single submitter
- CDR2L p.Ala274Asp Uncertain significance Single submitter
- CDR2L p.Ala5Ser Uncertain significance Single submitter
- CDR2L p.Ala81Ser Uncertain significance Single submitter
- CDR2L p.Arg121His Uncertain significance Single submitter
- CDR2L p.Arg146Gln Uncertain significance Single submitter
- CDR2L p.Arg151His Uncertain significance Single submitter
- CDR2L p.Arg153Cys Uncertain significance Single submitter
- CDR2L p.Arg153Leu Uncertain significance Single submitter
- CDR2L p.Arg169Gly Uncertain significance Single submitter
- CDR2L p.Arg175His Uncertain significance Single submitter
- CDR2L p.Arg194Gln Uncertain significance Single submitter
- CDR2L p.Arg375Gln Uncertain significance Single submitter
- CDR2L p.Arg382Gln Uncertain significance Single submitter
- CDR2L p.Arg402His Uncertain significance Single submitter
- CDR2L p.Arg428Leu Uncertain significance Single submitter
- CDR2L p.Asn455Ser Uncertain significance Single submitter
- CDR2L p.Asp172Glu Uncertain significance Single submitter
- CDR2L p.Asp20Asn Uncertain significance Single submitter
- CDR2L p.Glu182Lys Uncertain significance Single submitter
- CDR2L p.Glu405Asp Uncertain significance Single submitter
- CDR2L p.Gly184Ser Uncertain significance Single submitter
- CDR2L p.Gly310Asp Uncertain significance Single submitter
- CDR2L p.Gly310Cys Uncertain significance Single submitter
- CDR2L p.Gly349Val Uncertain significance Single submitter
- CDR2L p.Gly380Arg Uncertain significance Single submitter
- CDR2L p.Gly385Ser Uncertain significance Single submitter
- CDR2L p.Gly404Ser Uncertain significance Single submitter
- CDR2L p.Gly407Asp Uncertain significance Single submitter
- CDR2L p.Gly47Val Uncertain significance Single submitter
- CDR2L p.His113Leu Uncertain significance Single submitter
- CDR2L p.His156Leu Uncertain significance Single submitter
- CDR2L p.His334Gln Uncertain significance Single submitter
- CDR2L p.Ile119Thr Uncertain significance Single submitter
- CDR2L p.Leu176Gln Uncertain significance Single submitter
- CDR2L p.Leu181Val Uncertain significance Single submitter
- CDR2L p.Leu198Val Uncertain significance Single submitter
- CDR2L p.Met237Ile Uncertain significance Single submitter
- CDR2L p.Met237Thr Uncertain significance Single submitter
- CDR2L p.Val102Leu Uncertain significance Single submitter
- CDR2L p.Val223Glu Uncertain significance Single submitter
- CDR2L p.Val381Met Uncertain significance Single submitter
Predictors split 23
The independent predictors disagree with each other — read with care.
- CDR2L p.Arg146Trp Uncertain significance Single submitter
- CDR2L p.Arg151Cys Uncertain significance Single submitter
- CDR2L p.Arg169Trp Uncertain significance Single submitter
- CDR2L p.Arg186Trp Uncertain significance Single submitter
- CDR2L p.Arg314Cys Uncertain significance Single submitter
- CDR2L p.Arg333Trp Uncertain significance Single submitter
- CDR2L p.Arg428Trp Uncertain significance Single submitter
- CDR2L p.Arg74Gln Uncertain significance Single submitter
- CDR2L p.Asn98Ser Uncertain significance Single submitter
- CDR2L p.Gln123His Uncertain significance Single submitter
- CDR2L p.Gln211Pro Uncertain significance Single submitter
- CDR2L p.Gln376His Uncertain significance Single submitter
- CDR2L p.Gln387His Uncertain significance Single submitter
- CDR2L p.Gln86Lys Uncertain significance Single submitter
- CDR2L p.Leu101Met Uncertain significance Single submitter
- CDR2L p.Leu115Met Uncertain significance Single submitter
- CDR2L p.Leu242Pro Uncertain significance Single submitter
- CDR2L p.Leu49Val Uncertain significance Single submitter
- CDR2L p.Met257Ile Uncertain significance Single submitter
- CDR2L p.Ser48Phe Uncertain significance Single submitter
- CDR2L p.Trp18Arg Uncertain significance Single submitter
- CDR2L p.Val244Glu Uncertain significance Single submitter
- CDR2L p.Val76Met Uncertain significance Single submitter
All CDR2L variants
Uncertain significance 66
- p.Ala201Glu Single submitter ⚠
- p.Ala222Thr Single submitter ⚠
- p.Ala274Asp Single submitter ⚠
- p.Ala5Ser Single submitter ⚠
- p.Ala81Ser Single submitter ⚠
- p.Arg121His Single submitter ⚠
- p.Arg146Gln Single submitter ⚠
- p.Arg146Trp Single submitter ⚠
- p.Arg151Cys Single submitter ⚠
- p.Arg151His Single submitter ⚠
- p.Arg153Cys Single submitter ⚠
- p.Arg153Leu Single submitter ⚠
- p.Arg169Gly Single submitter ⚠
- p.Arg169Trp Single submitter ⚠
- p.Arg175His Single submitter ⚠
- p.Arg186Trp Single submitter ⚠
- p.Arg194Gln Single submitter ⚠
- p.Arg314Cys Single submitter ⚠
- p.Arg333Trp Single submitter ⚠
- p.Arg375Gln Single submitter ⚠
- p.Arg382Gln Single submitter ⚠
- p.Arg402His Single submitter ⚠
- p.Arg428Leu Single submitter ⚠
- p.Arg428Trp Single submitter ⚠
- p.Arg74Gln Single submitter ⚠
- p.Asn455Ser Single submitter ⚠
- p.Asn98Ser Single submitter ⚠
- p.Asp172Glu Single submitter ⚠
- p.Asp20Asn Single submitter ⚠
- p.Gln123His Single submitter ⚠
- p.Gln211Pro Single submitter ⚠
- p.Gln376His Single submitter ⚠
- p.Gln387His Single submitter ⚠
- p.Gln86Lys Single submitter ⚠
- p.Glu182Lys Single submitter ⚠
- p.Glu405Asp Single submitter ⚠
- p.Gly184Ser Single submitter ⚠
- p.Gly310Asp Single submitter ⚠
- p.Gly310Cys Single submitter ⚠
- p.Gly349Val Single submitter ⚠
- p.Gly380Arg Single submitter ⚠
- p.Gly385Ser Single submitter ⚠
- p.Gly404Ser Single submitter ⚠
- p.Gly407Asp Single submitter ⚠
- p.Gly47Val Single submitter ⚠
- p.His113Leu Single submitter ⚠
- p.His156Leu Single submitter ⚠
- p.His334Gln Single submitter ⚠
- p.Ile119Thr Single submitter ⚠
- p.Leu101Met Single submitter ⚠
- p.Leu115Met Single submitter ⚠
- p.Leu176Gln Single submitter ⚠
- p.Leu181Val Single submitter ⚠
- p.Leu198Val Single submitter ⚠
- p.Leu242Pro Single submitter ⚠
- p.Leu49Val Single submitter ⚠
- p.Met237Ile Single submitter ⚠
- p.Met237Thr Single submitter ⚠
- p.Met257Ile Single submitter ⚠
- p.Ser48Phe Single submitter ⚠
- p.Trp18Arg Single submitter ⚠
- p.Val102Leu Single submitter ⚠
- p.Val223Glu Single submitter ⚠
- p.Val244Glu Single submitter ⚠
- p.Val381Met Single submitter ⚠
- p.Val76Met Single submitter ⚠