CDRT15 — 33 ClinVar variants
All ClinVar germline CDRT15 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 31 flagged for review →
2 Likely benign · 31 Uncertain significance
Full CDRT15 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 31
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 31
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CDRT15 p.Ala100Glu Uncertain significance Single submitter
- CDRT15 p.Ala102Val Uncertain significance Single submitter
- CDRT15 p.Ala112Val Uncertain significance Single submitter
- CDRT15 p.Arg15Gly Uncertain significance Single submitter
- CDRT15 p.Arg27Gly Uncertain significance Single submitter
- CDRT15 p.Arg36His Uncertain significance Single submitter
- CDRT15 p.Cys92Arg Uncertain significance Single submitter
- CDRT15 p.Glu104Lys Uncertain significance Single submitter
- CDRT15 p.Glu106Gln Uncertain significance Single submitter
- CDRT15 p.Glu141Gly Uncertain significance Single submitter
- CDRT15 p.Gly17Arg Uncertain significance Single submitter
- CDRT15 p.Gly185Arg Uncertain significance Single submitter
- CDRT15 p.Gly18Arg Uncertain significance Single submitter
- CDRT15 p.Gly58Ser Uncertain significance Single submitter
- CDRT15 p.Gly67Arg Uncertain significance Single submitter
- CDRT15 p.His33Tyr Uncertain significance Single submitter
- CDRT15 p.Ile82Thr Uncertain significance Single submitter
- CDRT15 p.Leu163Phe Uncertain significance Single submitter
- CDRT15 p.Leu87Phe Uncertain significance Single submitter
- CDRT15 p.Pro101Gln Uncertain significance Single submitter
- CDRT15 p.Pro113His Uncertain significance Single submitter
- CDRT15 p.Pro124Ala Uncertain significance Single submitter
- CDRT15 p.Pro140Leu Uncertain significance Single submitter
- CDRT15 p.Pro48Leu Uncertain significance Single submitter
- CDRT15 p.Pro7Leu Uncertain significance Single submitter
- CDRT15 p.Pro7Ser Uncertain significance Single submitter
- CDRT15 p.Pro91Ala Uncertain significance Single submitter
- CDRT15 p.Ser19Asn Uncertain significance Single submitter
- CDRT15 p.Ser38Leu Uncertain significance Single submitter
- CDRT15 p.Thr129Ile Uncertain significance Single submitter
- CDRT15 p.Val47Ile Uncertain significance Single submitter
All CDRT15 variants
Likely benign 2
- c.-5G>A Single submitter
- p.Ala103Val Single submitter
Uncertain significance 31
- p.Ala100Glu Single submitter ⚠
- p.Ala102Val Single submitter ⚠
- p.Ala112Val Single submitter ⚠
- p.Arg15Gly Single submitter ⚠
- p.Arg27Gly Single submitter ⚠
- p.Arg36His Single submitter ⚠
- p.Cys92Arg Single submitter ⚠
- p.Glu104Lys Single submitter ⚠
- p.Glu106Gln Single submitter ⚠
- p.Glu141Gly Single submitter ⚠
- p.Gly17Arg Single submitter ⚠
- p.Gly185Arg Single submitter ⚠
- p.Gly18Arg Single submitter ⚠
- p.Gly58Ser Single submitter ⚠
- p.Gly67Arg Single submitter ⚠
- p.His33Tyr Single submitter ⚠
- p.Ile82Thr Single submitter ⚠
- p.Leu163Phe Single submitter ⚠
- p.Leu87Phe Single submitter ⚠
- p.Pro101Gln Single submitter ⚠
- p.Pro113His Single submitter ⚠
- p.Pro124Ala Single submitter ⚠
- p.Pro140Leu Single submitter ⚠
- p.Pro48Leu Single submitter ⚠
- p.Pro7Leu Single submitter ⚠
- p.Pro7Ser Single submitter ⚠
- p.Pro91Ala Single submitter ⚠
- p.Ser19Asn Single submitter ⚠
- p.Ser38Leu Single submitter ⚠
- p.Thr129Ile Single submitter ⚠
- p.Val47Ile Single submitter ⚠