CDRT15L2 — 59 ClinVar variants
All ClinVar germline CDRT15L2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 56 flagged for review →
3 Likely benign · 56 Uncertain significance
Full CDRT15L2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 56
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 53
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CDRT15L2 p.Ala100Val Uncertain significance Single submitter
- CDRT15L2 p.Ala118Glu Uncertain significance Single submitter
- CDRT15L2 p.Ala118Val Uncertain significance Single submitter
- CDRT15L2 p.Ala150Val Uncertain significance Single submitter
- CDRT15L2 p.Ala211Val Uncertain significance Single submitter
- CDRT15L2 p.Ala272Asp Uncertain significance Single submitter
- CDRT15L2 p.Ala272Val Uncertain significance Single submitter
- CDRT15L2 p.Ala94Gly Uncertain significance Single submitter
- CDRT15L2 p.Arg117Lys Uncertain significance Single submitter
- CDRT15L2 p.Arg160Lys Uncertain significance Single submitter
- CDRT15L2 p.Arg253His Uncertain significance Single submitter
- CDRT15L2 p.Arg253Leu Uncertain significance Single submitter
- CDRT15L2 p.Arg278Gly Uncertain significance Single submitter
- CDRT15L2 p.Arg36Leu Uncertain significance Single submitter
- CDRT15L2 p.Arg42Thr Uncertain significance Single submitter
- CDRT15L2 p.Arg44His Uncertain significance Single submitter
- CDRT15L2 p.Arg80Trp Uncertain significance Single submitter
- CDRT15L2 p.Asn254Ser Uncertain significance Single submitter
- CDRT15L2 p.Asp128Glu Uncertain significance Single submitter
- CDRT15L2 p.Asp188Tyr Uncertain significance Single submitter
- CDRT15L2 p.Cys4Tyr Uncertain significance Single submitter
- CDRT15L2 p.Gln192Pro Uncertain significance Single submitter
- CDRT15L2 p.Glu120Lys Uncertain significance Single submitter
- CDRT15L2 p.Gly155Glu Uncertain significance Single submitter
- CDRT15L2 p.Gly200Arg Uncertain significance Single submitter
- CDRT15L2 p.Gly91Val Uncertain significance Single submitter
- CDRT15L2 p.His71Tyr Uncertain significance Single submitter
- CDRT15L2 p.Ile227Ser Uncertain significance Single submitter
- CDRT15L2 p.Ile96Arg Uncertain significance Single submitter
- CDRT15L2 p.Ile96Leu Uncertain significance Single submitter
- CDRT15L2 p.Leu196Arg Uncertain significance Single submitter
- CDRT15L2 p.Leu196Val Uncertain significance Single submitter
- CDRT15L2 p.Leu198Ile Uncertain significance Single submitter
- CDRT15L2 p.Leu198Phe Uncertain significance Single submitter
- CDRT15L2 p.Lys234Asn Uncertain significance Single submitter
- CDRT15L2 p.Pro102Leu Uncertain significance Single submitter
- CDRT15L2 p.Pro115Leu Uncertain significance Single submitter
- CDRT15L2 p.Pro135Leu Uncertain significance Single submitter
- CDRT15L2 p.Pro176Leu Uncertain significance Single submitter
- CDRT15L2 p.Pro273Ser Uncertain significance Single submitter
- CDRT15L2 p.Pro39Leu Uncertain significance Single submitter
- CDRT15L2 p.Pro82Arg Uncertain significance Single submitter
- CDRT15L2 p.Pro92Ser Uncertain significance Single submitter
- CDRT15L2 p.Ser51Gly Uncertain significance Single submitter
- CDRT15L2 p.Ser66Leu Uncertain significance Single submitter
- CDRT15L2 p.Thr45Ile Uncertain significance Single submitter
- CDRT15L2 p.Trp260Arg Uncertain significance Single submitter
- CDRT15L2 p.Val104Ile Uncertain significance Single submitter
- CDRT15L2 p.Val121Leu Uncertain significance Single submitter
- CDRT15L2 p.Val121Met Uncertain significance Single submitter
- CDRT15L2 p.Val142Ala Uncertain significance Single submitter
- CDRT15L2 p.Val231Glu Uncertain significance Single submitter
- CDRT15L2 p.Val263Ile Uncertain significance Single submitter
Predictors split 3
The independent predictors disagree with each other — read with care.
All CDRT15L2 variants
Likely benign 3
- p.Ala207Thr Single submitter
- p.Gly187Arg Single submitter
- p.Ser235= Single submitter
Uncertain significance 56
- p.Ala100Val Single submitter ⚠
- p.Ala118Glu Single submitter ⚠
- p.Ala118Val Single submitter ⚠
- p.Ala150Val Single submitter ⚠
- p.Ala211Val Single submitter ⚠
- p.Ala272Asp Single submitter ⚠
- p.Ala272Val Single submitter ⚠
- p.Ala94Gly Single submitter ⚠
- p.Arg117Lys Single submitter ⚠
- p.Arg160Lys Single submitter ⚠
- p.Arg253His Single submitter ⚠
- p.Arg253Leu Single submitter ⚠
- p.Arg278Gly Single submitter ⚠
- p.Arg36Leu Single submitter ⚠
- p.Arg42Thr Single submitter ⚠
- p.Arg44His Single submitter ⚠
- p.Arg80Trp Single submitter ⚠
- p.Asn254Ser Single submitter ⚠
- p.Asp128Glu Single submitter ⚠
- p.Asp188Tyr Single submitter ⚠
- p.Cys4Tyr Single submitter ⚠
- p.Gln192Pro Single submitter ⚠
- p.Glu120Lys Single submitter ⚠
- p.Gly155Glu Single submitter ⚠
- p.Gly200Arg Single submitter ⚠
- p.Gly91Val Single submitter ⚠
- p.His71Tyr Single submitter ⚠
- p.Ile227Ser Single submitter ⚠
- p.Ile96Arg Single submitter ⚠
- p.Ile96Leu Single submitter ⚠
- p.Leu196Arg Single submitter ⚠
- p.Leu196Val Single submitter ⚠
- p.Leu198Ile Single submitter ⚠
- p.Leu198Phe Single submitter ⚠
- p.Leu223Pro Single submitter ⚠
- p.Lys234Asn Single submitter ⚠
- p.Phe2Leu Single submitter ⚠
- p.Pro102Leu Single submitter ⚠
- p.Pro115Leu Single submitter ⚠
- p.Pro135Leu Single submitter ⚠
- p.Pro176Leu Single submitter ⚠
- p.Pro273Ser Single submitter ⚠
- p.Pro39Leu Single submitter ⚠
- p.Pro82Arg Single submitter ⚠
- p.Pro92Ser Single submitter ⚠
- p.Ser51Gly Single submitter ⚠
- p.Ser66Leu Single submitter ⚠
- p.Thr45Ile Single submitter ⚠
- p.Trp260Arg Single submitter ⚠
- p.Trp260Cys Single submitter ⚠
- p.Val104Ile Single submitter ⚠
- p.Val121Leu Single submitter ⚠
- p.Val121Met Single submitter ⚠
- p.Val142Ala Single submitter ⚠
- p.Val231Glu Single submitter ⚠
- p.Val263Ile Single submitter ⚠