CDRT4 — 22 ClinVar variants
All ClinVar germline CDRT4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 19 flagged for review →
5 Likely benign · 17 Uncertain significance
Full CDRT4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 19
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 15
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CDRT4 p.Arg140His Uncertain significance Single submitter
- CDRT4 p.Arg140Leu Uncertain significance Single submitter
- CDRT4 p.Arg151Cys Uncertain significance Single submitter
- CDRT4 p.Arg20Gln Uncertain significance Single submitter
- CDRT4 p.Arg20Trp Uncertain significance Single submitter
- CDRT4 p.Arg78Lys Uncertain significance Single submitter
- CDRT4 p.Glu60Gly Uncertain significance Single submitter
- CDRT4 p.Gly103Val Uncertain significance Single submitter
- CDRT4 p.Met143Thr Uncertain significance Single submitter
- CDRT4 p.Met6Val Uncertain significance Single submitter
- CDRT4 p.Pro118His Uncertain significance Single submitter
- CDRT4 p.Pro76Thr Uncertain significance Single submitter
- CDRT4 p.Thr149Ala Uncertain significance Single submitter
- CDRT4 p.Thr34Ile Uncertain significance Single submitter
- CDRT4 p.Thr39Ala Uncertain significance Single submitter
Predictors split 4
The independent predictors disagree with each other — read with care.
All CDRT4 variants
Likely benign 5
- p.Ala104Thr Single submitter
- p.Arg5Lys Single submitter
- p.Met101Val Single submitter
- p.Thr93Met Single submitter ⚠
- p.Thr98Met Single submitter ⚠
Uncertain significance 17
- p.Arg140His Single submitter ⚠
- p.Arg140Leu Single submitter ⚠
- p.Arg151Cys Single submitter ⚠
- p.Arg20Gln Single submitter ⚠
- p.Arg20Trp Single submitter ⚠
- p.Arg78Lys Single submitter ⚠
- p.Glu60Gly Single submitter ⚠
- p.Gly103Val Single submitter ⚠
- p.Met143Thr Single submitter ⚠
- p.Met6Val Single submitter ⚠
- p.Pro118His Single submitter ⚠
- p.Pro30Leu Single submitter ⚠
- p.Pro76Thr Single submitter ⚠
- p.Ser97Tyr Single submitter ⚠
- p.Thr149Ala Single submitter ⚠
- p.Thr34Ile Single submitter ⚠
- p.Thr39Ala Single submitter ⚠