CDS2 — 31 ClinVar variants
All ClinVar germline CDS2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 30 flagged for review →
2 Likely benign · 29 Uncertain significance
Full CDS2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 30
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 15
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CDS2 p.Ala398Thr Uncertain significance Single submitter
- CDS2 p.Arg167Trp Uncertain significance Single submitter
- CDS2 p.Asp147Gly Uncertain significance Single submitter
- CDS2 p.Gly378Asp Uncertain significance Single submitter
- CDS2 p.His107Gln Uncertain significance Single submitter
- CDS2 p.Ile264Asn Uncertain significance Single submitter
- CDS2 p.Ile340Val Uncertain significance Single submitter
- CDS2 p.Met241Ile Uncertain significance Single submitter
- CDS2 p.Met99Leu Uncertain significance Single submitter
- CDS2 p.Phe140Ile Uncertain significance Single submitter
- CDS2 p.Thr270Ala Uncertain significance Single submitter
- CDS2 p.Thr442Ser Uncertain significance Single submitter
- CDS2 p.Tyr279Cys Uncertain significance Single submitter
- CDS2 p.Val101Ile Uncertain significance Single submitter
- CDS2 p.Val116Ile Uncertain significance Single submitter
Predictors split 15
The independent predictors disagree with each other — read with care.
- CDS2 p.Ala346Ser Uncertain significance Single submitter
- CDS2 p.Arg311His Uncertain significance Single submitter
- CDS2 p.Arg429Gln Uncertain significance Single submitter
- CDS2 p.Asn426Ser Uncertain significance Single submitter
- CDS2 p.His189Arg Uncertain significance Single submitter
- CDS2 p.Ile264Thr Uncertain significance Single submitter
- CDS2 p.Ile96Met Likely benign Single submitter
- CDS2 p.Met99Thr Uncertain significance Single submitter
- CDS2 p.Pro52Leu Uncertain significance Single submitter
- CDS2 p.Ser307Leu Uncertain significance Single submitter
- CDS2 p.Ser33Leu Uncertain significance Single submitter
- CDS2 p.Ser41Phe Uncertain significance Single submitter
- CDS2 p.Ser440Cys Uncertain significance Single submitter
- CDS2 p.Thr427Met Uncertain significance Single submitter
- CDS2 p.Tyr315Cys Uncertain significance Single submitter
All CDS2 variants
Likely benign 2
- p.Ile96Met Single submitter ⚠
- p.Ser440Ala Single submitter
Uncertain significance 29
- p.Ala346Ser Single submitter ⚠
- p.Ala398Thr Single submitter ⚠
- p.Arg167Trp Single submitter ⚠
- p.Arg311His Single submitter ⚠
- p.Arg429Gln Single submitter ⚠
- p.Asn426Ser Single submitter ⚠
- p.Asp147Gly Single submitter ⚠
- p.Gly378Asp Single submitter ⚠
- p.His107Gln Single submitter ⚠
- p.His189Arg Single submitter ⚠
- p.Ile264Asn Single submitter ⚠
- p.Ile264Thr Single submitter ⚠
- p.Ile340Val Single submitter ⚠
- p.Met241Ile Single submitter ⚠
- p.Met99Leu Single submitter ⚠
- p.Met99Thr Single submitter ⚠
- p.Phe140Ile Single submitter ⚠
- p.Pro52Leu Single submitter ⚠
- p.Ser307Leu Single submitter ⚠
- p.Ser33Leu Single submitter ⚠
- p.Ser41Phe Single submitter ⚠
- p.Ser440Cys Single submitter ⚠
- p.Thr270Ala Single submitter ⚠
- p.Thr427Met Single submitter ⚠
- p.Thr442Ser Single submitter ⚠
- p.Tyr279Cys Single submitter ⚠
- p.Tyr315Cys Single submitter ⚠
- p.Val101Ile Single submitter ⚠
- p.Val116Ile Single submitter ⚠