CDV3 — 33 ClinVar variants
All ClinVar germline CDV3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 33 flagged for review →
33 Uncertain significance
Full CDV3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 33
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 16
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CDV3 p.Ala68Gly Uncertain significance Single submitter
- CDV3 p.Ala68Pro Uncertain significance Single submitter
- CDV3 p.Arg117Gly Uncertain significance Single submitter
- CDV3 p.Arg208Gln Uncertain significance Single submitter
- CDV3 p.Asn224Ser Uncertain significance Single submitter
- CDV3 p.Asn233His Uncertain significance Single submitter
- CDV3 p.Asn242Tyr Uncertain significance Single submitter
- CDV3 p.Glu111Asp Uncertain significance Single submitter
- CDV3 p.Glu135Gly Uncertain significance Single submitter
- CDV3 p.Glu89Asp Uncertain significance Single submitter
- CDV3 p.Gly33Ser Uncertain significance Single submitter
- CDV3 p.Leu247Arg Uncertain significance Single submitter
- CDV3 p.Lys237Gln Uncertain significance Single submitter
- CDV3 p.Met134Thr Uncertain significance Single submitter
- CDV3 p.Met164Leu Uncertain significance Single submitter
- CDV3 p.Trp124Leu Uncertain significance Single submitter
Predictors split 17
The independent predictors disagree with each other — read with care.
- CDV3 p.Ala145Gly Uncertain significance Single submitter
- CDV3 p.Ala149Val Uncertain significance Single submitter
- CDV3 p.Ala35Val Uncertain significance Single submitter
- CDV3 p.Ala52Val Uncertain significance Single submitter
- CDV3 p.Ala73Val Uncertain significance Single submitter
- CDV3 p.Asn233Ile Uncertain significance Single submitter
- CDV3 p.Asn249Tyr Uncertain significance Single submitter
- CDV3 p.Asp17Asn Uncertain significance Single submitter
- CDV3 p.Asp83Tyr Uncertain significance Single submitter
- CDV3 p.Glu92Lys Uncertain significance Single submitter
- CDV3 p.Gly132Arg Uncertain significance Single submitter
- CDV3 p.Gly49Asp Uncertain significance Single submitter
- CDV3 p.Gly51Arg Uncertain significance Single submitter
- CDV3 p.Pro140Ser Uncertain significance Single submitter
- CDV3 p.Pro58Leu Uncertain significance Single submitter
- CDV3 p.Ser231Leu Uncertain significance Single submitter
- CDV3 p.Thr177Ile Uncertain significance Single submitter
All CDV3 variants
Uncertain significance 33
- p.Ala145Gly Single submitter ⚠
- p.Ala149Val Single submitter ⚠
- p.Ala35Val Single submitter ⚠
- p.Ala52Val Single submitter ⚠
- p.Ala68Gly Single submitter ⚠
- p.Ala68Pro Single submitter ⚠
- p.Ala73Val Single submitter ⚠
- p.Arg117Gly Single submitter ⚠
- p.Arg208Gln Single submitter ⚠
- p.Asn224Ser Single submitter ⚠
- p.Asn233His Single submitter ⚠
- p.Asn233Ile Single submitter ⚠
- p.Asn242Tyr Single submitter ⚠
- p.Asn249Tyr Single submitter ⚠
- p.Asp17Asn Single submitter ⚠
- p.Asp83Tyr Single submitter ⚠
- p.Glu111Asp Single submitter ⚠
- p.Glu135Gly Single submitter ⚠
- p.Glu89Asp Single submitter ⚠
- p.Glu92Lys Single submitter ⚠
- p.Gly132Arg Single submitter ⚠
- p.Gly33Ser Single submitter ⚠
- p.Gly49Asp Single submitter ⚠
- p.Gly51Arg Single submitter ⚠
- p.Leu247Arg Single submitter ⚠
- p.Lys237Gln Single submitter ⚠
- p.Met134Thr Single submitter ⚠
- p.Met164Leu Single submitter ⚠
- p.Pro140Ser Single submitter ⚠
- p.Pro58Leu Single submitter ⚠
- p.Ser231Leu Single submitter ⚠
- p.Thr177Ile Single submitter ⚠
- p.Trp124Leu Single submitter ⚠