CDX1 — 55 ClinVar variants
All ClinVar germline CDX1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 54 flagged for review →
1 Likely benign · 54 Uncertain significance
Full CDX1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 54
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 28
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CDX1 p.Ala38Pro Uncertain significance Single submitter
- CDX1 p.Ala63Pro Uncertain significance Single submitter
- CDX1 p.Arg152Trp Uncertain significance Single submitter
- CDX1 p.Arg166His Uncertain significance Single submitter
- CDX1 p.Arg182Leu Uncertain significance Single submitter
- CDX1 p.Arg183Gln Uncertain significance Single submitter
- CDX1 p.Arg183Trp Uncertain significance Single submitter
- CDX1 p.Arg196Trp Uncertain significance Single submitter
- CDX1 p.Asp8Gly Uncertain significance Single submitter
- CDX1 p.Glu261Asp Uncertain significance Single submitter
- CDX1 p.Glu261Lys Uncertain significance Single submitter
-
CDX1 p.Gly144Ser
Uncertain significance
Single submitter
CDX1-related disorder
- CDX1 p.Gly149Asp Uncertain significance Single submitter
- CDX1 p.Gly192Arg Uncertain significance Single submitter
- CDX1 p.Gly242Asp Uncertain significance Single submitter
- CDX1 p.Gly31Val Uncertain significance Single submitter
- CDX1 p.His164Pro Uncertain significance Single submitter
- CDX1 p.His229Arg Uncertain significance Single submitter
- CDX1 p.His229Asn Uncertain significance Single submitter
- CDX1 p.Leu116His Uncertain significance Single submitter
- CDX1 p.Met257Ile Uncertain significance Single submitter
- CDX1 p.Phe173Ile Uncertain significance Single submitter
- CDX1 p.Pro104Ser Uncertain significance Single submitter
- CDX1 p.Pro39Ser Uncertain significance Single submitter
- CDX1 p.Ser46Cys Uncertain significance Single submitter
- CDX1 p.Ser49Cys Uncertain significance Single submitter
- CDX1 p.Trp135Cys Uncertain significance Single submitter
- CDX1 p.Val159Met Uncertain significance Single submitter
Predictors split 26
The independent predictors disagree with each other — read with care.
- CDX1 p.Gly143Arg Uncertain significance Multiple submitters
- CDX1 p.Ala21Val Uncertain significance Single submitter
- CDX1 p.Ala60Val Uncertain significance Single submitter
- CDX1 p.Ala82Val Uncertain significance Single submitter
- CDX1 p.Arg137Leu Uncertain significance Single submitter
- CDX1 p.Arg182Gln Uncertain significance Single submitter
- CDX1 p.Asn213Ser Uncertain significance Single submitter
- CDX1 p.Asp71Tyr Uncertain significance Single submitter
- CDX1 p.Gly126Glu Uncertain significance Single submitter
- CDX1 p.Gly145Asp Uncertain significance Single submitter
- CDX1 p.Gly24Asp Uncertain significance Single submitter
- CDX1 p.Pro107Ser Uncertain significance Single submitter
- CDX1 p.Pro17Gln Uncertain significance Single submitter
- CDX1 p.Pro225Leu Uncertain significance Single submitter
- CDX1 p.Pro226Leu Uncertain significance Single submitter
- CDX1 p.Pro36His Uncertain significance Single submitter
- CDX1 p.Pro40Arg Uncertain significance Single submitter
- CDX1 p.Pro57Leu Uncertain significance Single submitter
- CDX1 p.Ser22Ile Uncertain significance Single submitter
- CDX1 p.Ser249Asn Uncertain significance Single submitter
- CDX1 p.Ser47Thr Uncertain significance Single submitter
- CDX1 p.Ser86Cys Uncertain significance Single submitter
- CDX1 p.Thr253Ile Uncertain significance Single submitter
- CDX1 p.Trp72Cys Uncertain significance Single submitter
- CDX1 p.Tyr133Cys Uncertain significance Single submitter
- CDX1 p.Tyr5Cys Uncertain significance Single submitter
All CDX1 variants
Likely benign 1
- p.Met227Thr Single submitter
Uncertain significance 54
- p.Gly143Arg Multiple submitters ⚠
- p.Ala21Val Single submitter ⚠
- p.Ala38Pro Single submitter ⚠
- p.Ala60Val Single submitter ⚠
- p.Ala63Pro Single submitter ⚠
- p.Ala82Val Single submitter ⚠
- p.Arg137Leu Single submitter ⚠
- p.Arg152Trp Single submitter ⚠
- p.Arg166His Single submitter ⚠
- p.Arg182Gln Single submitter ⚠
- p.Arg182Leu Single submitter ⚠
- p.Arg183Gln Single submitter ⚠
- p.Arg183Trp Single submitter ⚠
- p.Arg196Trp Single submitter ⚠
- p.Asn213Ser Single submitter ⚠
- p.Asp71Tyr Single submitter ⚠
- p.Asp8Gly Single submitter ⚠
- p.Glu261Asp Single submitter ⚠
- p.Glu261Lys Single submitter ⚠
- p.Gly126Glu Single submitter ⚠
- p.Gly144Ser Single submitter CDX1-related disorder ⚠
- p.Gly145Asp Single submitter ⚠
- p.Gly149Asp Single submitter ⚠
- p.Gly192Arg Single submitter ⚠
- p.Gly242Asp Single submitter ⚠
- p.Gly24Asp Single submitter ⚠
- p.Gly31Val Single submitter ⚠
- p.His164Pro Single submitter ⚠
- p.His229Arg Single submitter ⚠
- p.His229Asn Single submitter ⚠
- p.Leu116His Single submitter ⚠
- p.Met257Ile Single submitter ⚠
- p.Phe173Ile Single submitter ⚠
- p.Pro104Ser Single submitter ⚠
- p.Pro107Ser Single submitter ⚠
- p.Pro17Gln Single submitter ⚠
- p.Pro225Leu Single submitter ⚠
- p.Pro226Leu Single submitter ⚠
- p.Pro36His Single submitter ⚠
- p.Pro39Ser Single submitter ⚠
- p.Pro40Arg Single submitter ⚠
- p.Pro57Leu Single submitter ⚠
- p.Ser22Ile Single submitter ⚠
- p.Ser249Asn Single submitter ⚠
- p.Ser46Cys Single submitter ⚠
- p.Ser47Thr Single submitter ⚠
- p.Ser49Cys Single submitter ⚠
- p.Ser86Cys Single submitter ⚠
- p.Thr253Ile Single submitter ⚠
- p.Trp135Cys Single submitter ⚠
- p.Trp72Cys Single submitter ⚠
- p.Tyr133Cys Single submitter ⚠
- p.Tyr5Cys Single submitter ⚠
- p.Val159Met Single submitter ⚠