CDX4 — 38 ClinVar variants
All ClinVar germline CDX4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 33 flagged for review →
1 Conflicting · 5 Likely benign · 32 Uncertain significance
Full CDX4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 33
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors agree, ClinVar conflicts 1
ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.
Predictors lean, ClinVar uncertain 25
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CDX4 p.Ala106Ser Uncertain significance Single submitter
- CDX4 p.Ala207Thr Uncertain significance Single submitter
- CDX4 p.Ala226Gly Uncertain significance Single submitter
- CDX4 p.Arg177His Uncertain significance Single submitter
- CDX4 p.Arg215Lys Uncertain significance Single submitter
- CDX4 p.Arg215Thr Uncertain significance Single submitter
- CDX4 p.Arg270Cys Uncertain significance Single submitter
- CDX4 p.Asp182Gly Uncertain significance Single submitter
- CDX4 p.Asp63His Uncertain significance Single submitter
- CDX4 p.Gln184Arg Uncertain significance Single submitter
- CDX4 p.Gln238Leu Uncertain significance Single submitter
- CDX4 p.Glu10Lys Uncertain significance Single submitter
- CDX4 p.Glu284Lys Uncertain significance Single submitter
- CDX4 p.Gly125Val Uncertain significance Single submitter
- CDX4 p.His52Tyr Uncertain significance Single submitter
- CDX4 p.Ile219Leu Uncertain significance Single submitter
- CDX4 p.Ile232Thr Uncertain significance Single submitter
- CDX4 p.Leu258Val Uncertain significance Single submitter
- CDX4 p.Leu69Val Uncertain significance Single submitter
- CDX4 p.Lys145Arg Uncertain significance Single submitter
- CDX4 p.Pro105Thr Uncertain significance Single submitter
- CDX4 p.Pro266Ser Uncertain significance Single submitter
- CDX4 p.Pro67Ala Uncertain significance Single submitter
- CDX4 p.Pro97Ser Uncertain significance Single submitter
- CDX4 p.Tyr56His Uncertain significance Single submitter
Predictors split 7
The independent predictors disagree with each other — read with care.
- CDX4 p.Arg161Gly Uncertain significance Single submitter
- CDX4 p.Cys194Arg Uncertain significance Single submitter
- CDX4 p.Gly121Cys Uncertain significance Single submitter
- CDX4 p.Ile236Thr Uncertain significance Single submitter
- CDX4 p.Pro97Leu Uncertain significance Single submitter
- CDX4 p.Ser267Tyr Uncertain significance Single submitter
- CDX4 p.Ser74Leu Uncertain significance Single submitter
All CDX4 variants
Conflicting classifications of pathogenicity 1
- p.Pro40Thr Single submitter ⚠
Likely benign 5
- p.Met39Ile Single submitter
- p.Pro67Gln Single submitter
- p.Pro89Gln Single submitter
- p.Thr167= Single submitter
- c.502+51G>C No assertion criteria CDX4-related disorder
Uncertain significance 32
- p.Ala106Ser Single submitter ⚠
- p.Ala207Thr Single submitter ⚠
- p.Ala226Gly Single submitter ⚠
- p.Arg161Gly Single submitter ⚠
- p.Arg177His Single submitter ⚠
- p.Arg215Lys Single submitter ⚠
- p.Arg215Thr Single submitter ⚠
- p.Arg270Cys Single submitter ⚠
- p.Asp182Gly Single submitter ⚠
- p.Asp63His Single submitter ⚠
- p.Cys194Arg Single submitter ⚠
- p.Gln184Arg Single submitter ⚠
- p.Gln238Leu Single submitter ⚠
- p.Glu10Lys Single submitter ⚠
- p.Glu284Lys Single submitter ⚠
- p.Gly121Cys Single submitter ⚠
- p.Gly125Val Single submitter ⚠
- p.His52Tyr Single submitter ⚠
- p.Ile219Leu Single submitter ⚠
- p.Ile232Thr Single submitter ⚠
- p.Ile236Thr Single submitter ⚠
- p.Leu258Val Single submitter ⚠
- p.Leu69Val Single submitter ⚠
- p.Lys145Arg Single submitter ⚠
- p.Pro105Thr Single submitter ⚠
- p.Pro266Ser Single submitter ⚠
- p.Pro67Ala Single submitter ⚠
- p.Pro97Leu Single submitter ⚠
- p.Pro97Ser Single submitter ⚠
- p.Ser267Tyr Single submitter ⚠
- p.Ser74Leu Single submitter ⚠
- p.Tyr56His Single submitter ⚠